2016
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense
Graf F, Ludin P, Arquint C, Schmidt R, Schaub N, Kunz Renggli C, Munday J, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning H, Mäser P. Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular And Molecular Life Sciences 2016, 73: 3387-3400. PMID: 26973180, PMCID: PMC4967103, DOI: 10.1007/s00018-016-2173-6.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAquaporinsComparative Genomic HybridizationDNA, ProtozoanDrug ResistanceGenome, ProtozoanHeterozygoteHumansMaleMelarsoprolNucleoside Transport ProteinsParasitic Sensitivity TestsPentamidinePhenotypePolymorphism, Single NucleotideProtozoan ProteinsRNA-Binding ProteinsSequence AlignmentTrypanocidal AgentsTrypanosoma brucei rhodesienseTrypanosomiasis, African
2014
Comparative Genomics Reveals Multiple Genetic Backgrounds of Human Pathogenicity in the Trypanosoma brucei Complex
Sistrom M, Evans B, Bjornson R, Gibson W, Balmer O, Mäser P, Aksoy S, Caccone A. Comparative Genomics Reveals Multiple Genetic Backgrounds of Human Pathogenicity in the Trypanosoma brucei Complex. Genome Biology And Evolution 2014, 6: 2811-2819. PMID: 25287146, PMCID: PMC4224348, DOI: 10.1093/gbe/evu222.Peer-Reviewed Original ResearchConceptsT. brucei complexGenomic variationLife historyVariable life historiesAverage linkage disequilibriumTrypanosoma brucei complexGenome-wide studiesMeiotic reciprocal recombinationWhole genome sequencesMultiple genetic backgroundsHuman pathogenicityNumber of subspeciesHuman-infective parasiteNuclear genomeComparative genomicsChromosome sizeEukaryotic parasitesGenomic regionsHuman African trypanosomiasisRegulatory genesTaxonomic designationsDiverse hostsSingle nucleotide polymorphismsGenetic variationReciprocal recombination