2012
Genetic isolation within the malaria mosquito Anopheles melas
Deitz K, Athrey G, Reddy M, Overgaard H, Matias A, Jawara M, della Torre A, Petrarca V, Pinto J, Kiszewski A, Kengne P, Costantini C, Caccone A, Slotman M. Genetic isolation within the malaria mosquito Anopheles melas. Molecular Ecology 2012, 21: 4498-4513. PMID: 22882458, PMCID: PMC4067978, DOI: 10.1111/j.1365-294x.2012.05724.x.Peer-Reviewed Original ResearchConceptsMicrosatellite dataIsland populationsGambiae complexMaximum likelihood phylogenetic analysisBp of mtDNALevel of divergenceLast glaciation periodA. gambiae complexMalaria vectorsSalt marsh grassAnopheles gambiae complexAnopheles melasMajor malaria vectorApproximate Bayesian analysisMtDNA divergenceGenetic differentiationGenetic divergenceGenetic isolationMainland populationsPhylogenetic analysisPopulation structureMicrosatellite markersLarval habitatsA. gambiaeGlaciation period
2010
Anopheles Immune Genes and Amino Acid Sites Evolving Under the Effect of Positive Selection
Parmakelis A, Moustaka M, Poulakakis N, Louis C, Slotman MA, Marshall JC, Awono-Ambene PH, Antonio-Nkondjio C, Simard F, Caccone A, Powell JR. Anopheles Immune Genes and Amino Acid Sites Evolving Under the Effect of Positive Selection. PLOS ONE 2010, 5: e8885. PMID: 20126662, PMCID: PMC2811201, DOI: 10.1371/journal.pone.0008885.Peer-Reviewed Original ResearchConceptsPositive selectionImmune genesGambiae complexDN/dS ratiosLineage-specific evolutionPopulation genetics frameworkAmino acid sitesAnopheles gambiae complexSpecific amino acidsInnate immunity genesAncestral polymorphismComparative phylogeneticsGene diversityEvolutionary historyNatural populationsGenetic diversityGenetic frameworkNatural selectionImmunity genesVector biologyDS ratiosGenesAmino acidsDiversityGenetic knowledge
2008
The molecular evolution of four anti-malarial immune genes in the Anopheles gambiae species complex
Parmakelis A, Slotman MA, Marshall JC, Awono-Ambene PH, Antonio-Nkondjio C, Simard F, Caccone A, Powell JR. The molecular evolution of four anti-malarial immune genes in the Anopheles gambiae species complex. BMC Ecology And Evolution 2008, 8: 79. PMID: 18325105, PMCID: PMC2288592, DOI: 10.1186/1471-2148-8-79.Peer-Reviewed Original ResearchConceptsInsect innate immune systemAnopheles gambiae speciesLevel of polymorphismAnopheles gambiae complexSpecific adaptive responsesAncestral polymorphismPhylogenetic frameworkMolecular evolutionSuch genesGambiae speciesPositive selectionImmunity genesSelection pressureCandidate genesImmune genesMosquito's abilityGambiae complexStudied genesGenesInnate immune systemAdaptive responseMalaria parasitesPlasmodium parasitesEase of manipulationSpeciesHistorical analysis of a near disaster: Anopheles gambiae in Brazil.
Parmakelis A, Russello MA, Caccone A, Marcondes CB, Costa J, Forattini OP, Sallum MA, Wilkerson RC, Powell JR. Historical analysis of a near disaster: Anopheles gambiae in Brazil. American Journal Of Tropical Medicine And Hygiene 2008, 78: 176-8. PMID: 18187802, DOI: 10.4269/ajtmh.2008.78.176.Peer-Reviewed Original ResearchConceptsHuman-mediated range expansionIntrinsic historical interestAnopheles gambiaeDisease vectorsHistorical DNA analysisHuman-mediated dispersalInsect disease vectorsMuseum collectionsHistorical analysisNear disasterHistorical interestAnopheles gambiae complexHistorical informationTime of invasionIntercontinental introductionSpecies complexSpecies identityRange expansionMuseum specimensGambiae complexGambiaeSpeciesAnopheles arabiensisIdentityDNA analysis
2007
Patterns of Selection in Anti-Malarial Immune Genes in Malaria Vectors: Evidence for Adaptive Evolution in LRIM1 in Anopheles arabiensis
Slotman MA, Parmakelis A, Marshall JC, Awono-Ambene PH, Antonio-Nkondjo C, Simard F, Caccone A, Powell JR. Patterns of Selection in Anti-Malarial Immune Genes in Malaria Vectors: Evidence for Adaptive Evolution in LRIM1 in Anopheles arabiensis. PLOS ONE 2007, 2: e793. PMID: 17726523, PMCID: PMC1945087, DOI: 10.1371/journal.pone.0000793.Peer-Reviewed Original ResearchConceptsAdaptive evolutionPrimary malaria vectorMalaria vectorsPatterns of selectionNon-vector speciesAnopheles gambiae complexMcDonald-KreitmanReplacement substitutionsPositive selectionGenetic variationMalaria vector AnLRIM1Immune genesSelection showGambiae complexGenesAdjacent codonsProtein differentiationLevel of resistanceAdaptive responsePlasmodium speciesCEC1Vector AnMaximum likelihood testSpecies
2002
Genetic Differentiation in the African Malaria Vector, Anopheles gambiae s.s., and the Problem of Taxonomic Status
Gentile G, della Torre A, Maegga B, Powell J, Caccone A. Genetic Differentiation in the African Malaria Vector, Anopheles gambiae s.s., and the Problem of Taxonomic Status. Genetics 2002, 161: 1561-1578. PMID: 12196401, PMCID: PMC1462204, DOI: 10.1093/genetics/161.4.1561.Peer-Reviewed Original ResearchConceptsRDNA typesIntergenic spacerChromosomal formsNominal speciesSavanna chromosomal formsSingle panmictic unitSingle nominal speciesInsecticide resistance genesAreas of sympatryAnopheles gambiae complexDistinct sequencesGambiae s.African malaria vectorsA. gambiae s.Genetic differentiationITS allelesGenetic discontinuityGenetic isolationPanmictic unitTaxonomic statusChromosome armsGeographic rangeRDNA regionComplete linkage disequilibriumAutosomal inversions
1999
Population structure, speciation, and introgression in the Anopheles gambiae complex.
Powell JR, Petrarca V, della Torre A, Caccone A, Coluzzi M. Population structure, speciation, and introgression in the Anopheles gambiae complex. Parassitologia 1999, 41: 101-13. PMID: 10697841.Peer-Reviewed Original ResearchConceptsAnopheles gambiae complexGambiae complexPopulation structureAdaptive genetic variationPresence of introgressionChromosome inversion polymorphismsDistribution of karyotypesMicro-geographic scaleGambiae s.Major environmental variablesDistinct genetic formsCryptic taxaPanmictic unitInversion polymorphismPhylogenetic dataChromosome inversionsLevels of aridityPhylogenetic studiesEvolutionary dynamicsGenetic variationWest African populationsImportant vectorKaryotype studiesMolecular studiesEnvironmental variables
1998
Multiple Origins of Cytologically Identical Chromosome Inversions in the Anopheles gambiae Complex
Caccone A, Min G, Powell J. Multiple Origins of Cytologically Identical Chromosome Inversions in the Anopheles gambiae Complex. Genetics 1998, 150: 807-814. PMID: 9755210, PMCID: PMC1460344, DOI: 10.1093/genetics/150.2.807.Peer-Reviewed Original ResearchConceptsA. merusAnopheles gambiae complexA. gambiaePolytene chromosomesA. arabiensisGambiae complexDNA sequence analysisPhylogenetic historySister taxaChromosomal inversionsChromosome inversionsPhylogenetic analysisParallel evolutionImportant genesDNA sequencesCommon ancestryMultiple originsSequence analysisAssumption of monophylyImmediate ancestorsImportant vectorGambiaeChromosomesFirst clear evidenceParticular inversion
1996
Inversion Monophyly in African Anopheline Malaria Vectors
García B, Caccone A, Mathiopoulos K, Powell J. Inversion Monophyly in African Anopheline Malaria Vectors. Genetics 1996, 143: 1313-1320. PMID: 8807303, PMCID: PMC1207400, DOI: 10.1093/genetics/143.3.1313.Peer-Reviewed Original ResearchConceptsA. gambiaeA. arabiensisX chromosome inversionAnopheles gambiae complexSpecies-specific regionsDNA phylogenyPolytene chromosomesPhylogenetic relationshipsSister taxaPhylogenetic inferenceA. merusDNA dataIntrogressionX inversionGambiae complexParacentric inversionGambiaeMalaria vectorsSpeciesSelective eliminationXAGArabiensisAnopheline malaria vectorsDrosophilaMonophylyEvolution of the mitochondrial DNA control region in the Anopheles gambiae complex
Caccone A, Garcia B, Powell J. Evolution of the mitochondrial DNA control region in the Anopheles gambiae complex. Insect Molecular Biology 1996, 5: 51-59. PMID: 8630535, DOI: 10.1111/j.1365-2583.1996.tb00040.x.Peer-Reviewed Original ResearchConceptsAnopheles gambiae complexChromosomal inversionsControl regionAT-rich control regionMtDNA protein-coding genesMitochondrial DNA control regionA. gambiaeGambiae complexMtDNA gene flowA. arabiensisProtein-coding genesDNA control regionAT-rich regionGene flowMolecular treesEvolutionary positionPhylogenetic positionMitochondrial DNAA. melasSpeciesThird positionGambiaeArabiensisIntra-individual variationTrees
1994
Molecular phylogeny of the Anopheles gambiae complex suggests genetic introgression between principal malaria vectors.
Besansky N, Powell J, Caccone A, Hamm D, Scott J, Collins F. Molecular phylogeny of the Anopheles gambiae complex suggests genetic introgression between principal malaria vectors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 6885-6888. PMID: 8041714, PMCID: PMC44302, DOI: 10.1073/pnas.91.15.6885.Peer-Reviewed Original ResearchConceptsAnopheles gambiae complexGambiae complexDNA sequence dataGenetic introgressionGene flowMolecular phylogenyEvolutionary relationshipsSister taxaChromosomal inversionsPhylogenetic treePrincipal malaria vectorAfrotropical speciesSequence dataA. gambiaeNonvector speciesDistant branchesSpeciesMalaria vectorsAnopheles arabiensisEfficient vectorPrincipal vectorIntrogressionPhylogenyMalaria control strategiesTaxa