Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsThomas Kosten
Professor Adjunct, PsychiatryAbout
Research
Publications
2025
Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases
Stratford J, Carnes M, Willis C, Minto M, Elnimeiry L, Mathur R, Schu M, Quach B, Carter J, Nolen T, Vandergrift N, Kosten T, Johnson E, Webb B. Identifying compounds to treat opiate use disorder by leveraging multi-omic data integration and multiple drug repurposing databases. Translational Psychiatry 2025, 15: 528. PMID: 41271629, PMCID: PMC12711988, DOI: 10.1038/s41398-025-03721-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesProtein-protein interactionsDrug repurposing studiesTherapeutic Target DatabaseGenome-wide association study risk lociProtein-protein interaction networkGene expressionMulti-omics data integrationRepurposing studiesOpioid use disorderNetwork analysisRisk lociAssociation studiesProtein-proteinDGE analysisTarget genesOpen TargetsUse disorderGenesStatistically significant supportPost-mortem human brainOpiate use disorderBiological evidenceTarget databaseAvailable pharmacotherapiesMitigating Post-Traumatic Stress Disorder Risk Through Gender-Sensitive Trauma-Informed Care in the Emergency Department—A Narrative Review
Larsen S, Davis J, Murphy N, Moukaddam N, Swann A, Kosten T, Hundt N, Verrico C, Elechi O, Thomas Y. Mitigating Post-Traumatic Stress Disorder Risk Through Gender-Sensitive Trauma-Informed Care in the Emergency Department—A Narrative Review. Journal Of Emergency Medicine 2025, 80: 241-251. PMID: 41319493, DOI: 10.1016/j.jemermed.2025.10.035.Peer-Reviewed Original ResearchTrauma-informed carePost-traumatic stress disorderEmergency departmentPost-traumatic stress disorder riskED settingED workflowElectronic health record promptsTrauma-informed care practicesStress disorderTrauma-informed care approachMental health servicesNarrative reviewChronic post-traumatic stress disorderPractice communication techniquesPatient riskPlain language explanationsTrauma patientsPTSD incidenceIntrusive re-experiencingAcute stress disorderNarrative literature reviewAdult trauma patientsED careReferral pathwaysWeb of ScienceReasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides.
De Martin S, Comai S, Mattarei A, Kosten T, Vocci F, Gorodetzky C, Pappagallo M, Manfredi P. Reasons for Maintaining the Classification of Esmethadone as an Investigational Uncompetitive NMDAR Antagonist Rapid Antidepressant: Reply to Ferré and Michaelides. The Journal Of Clinical Psychiatry 2025, 86 PMID: 40965842, DOI: 10.4088/jcp.25lr15973a.Peer-Reviewed Original ResearchUnderstanding traumatic injuries and suicide risk: A conceptual exploration for the emergency department
Thomas Y, Swann A, Murtaza S, Kosten T, Murphy N, Mathew S, Verrico C, Davis J, Moukaddam N. Understanding traumatic injuries and suicide risk: A conceptual exploration for the emergency department. Journal Of Affective Disorders 2025, 391: 119977. PMID: 40721143, DOI: 10.1016/j.jad.2025.119977.Peer-Reviewed Original ResearchConceptsEmergency departmentSuicide riskResponse to chronic stressEarly identification of at-risk individualsSocietal burdenContinuum of careSustained psychosocial supportEvidence-based interventionsIdentification of at-risk individualsDigital health technologiesBurden of suicideTrauma-informed careBehavioral sensitizationTrauma exposureAt-risk individualsEarly identificationSuicidal behaviorSuicide attemptsTraumatic injuryChronic stressPsychosocial supportCare pathwaysED presentationsPsychological traumaSuicideThe association between cannabis use and suicidal intensity in psychiatric inpatients
Oladunjoye A, Swann A, Kosten T, Patriquin M, Bigdeli T, Barr P, Wilkinson A, Harding M, Nielsen D, Graham D. The association between cannabis use and suicidal intensity in psychiatric inpatients. American Journal On Addictions 2025, 34: 506-516. PMID: 40349103, DOI: 10.1111/ajad.70047.Peer-Reviewed Original ResearchSuicidal ideation intensityCannabis usePsychiatric inpatientsPsychological flexibilityColumbia-Suicide Severity Rating ScaleAssociated with cannabis useSuicidal intensityMale psychiatric inpatientsSubstance Involvement Screening TestSeverity Rating ScaleModel of moderationEmotion regulationPsychiatric comorbidityPolygenic risk scoresPath analysis modelSuicidal ideationSuicide attemptsRating ScaleSex-specific patternsPotential mediatorsSuicideInpatientsAssociated with greater riskCannabisAdolescentsNitrate ameliorates alcohol-induced cognitive impairment via oral microbiota
Li X, Ni Z, Shi W, Zhao K, Zhang Y, Liu L, Wang Z, Chen J, Yu Z, Gao X, Qin Y, Zhao J, Peng W, Shi J, Kosten T, Lu L, Su L, Xue Y, Sun H. Nitrate ameliorates alcohol-induced cognitive impairment via oral microbiota. Journal Of Neuroinflammation 2025, 22: 106. PMID: 40234914, PMCID: PMC12001487, DOI: 10.1186/s12974-025-03439-x.Peer-Reviewed Original ResearchConceptsAlcohol-induced cognitive impairmentCognitive impairmentLevel of cognitive impairmentAssociated with cognitive impairmentChronic alcohol exposureAssociated with higher cognitive impairmentHigher cognitive impairmentOral microbiotaAlcohol exposureCognitive functionBrain functionCognitive declineAlcohol useImpairmentAlcohol consumptionBeneficial effectsGerm-free miceAlcohol drinkersOral nitratesAlcoholDysregulated inflammationNeuroinflammationMetabolism-related bacteriaDrinkersMiceInteracting immediate and long-term action regulation in suicidal behavior
Murphy N, Kypriotakis G, Lijffijt M, Iqbal S, Iqbal T, Amarneh D, O’Brien B, Tamman A, Thomas Y, Moukaddam N, Kosten T, Averill L, Mathew S, Swann A. Interacting immediate and long-term action regulation in suicidal behavior. Journal Of Mood And Anxiety Disorders 2025, 10: 100118. PMID: 40657602, PMCID: PMC12244047, DOI: 10.1016/j.xjmad.2025.100118.Peer-Reviewed Original ResearchImmediate memory taskInternal State ScaleLifetime cumulative adversityChildhood traumaSuicidal behaviorAction regulationSuicidal ideationSuicide attemptsTreatment of suicide riskSSI-WConventional psychiatric diagnosesSevere suicide attemptsRegulation of actionsPsychiatric controlsMemory taskAddictive behaviorsPsychiatric diagnosisEarly traumaSuicide riskSuicidal crisisBehavioral symptomsStimulus discriminationCumulative adversityState scaleSuicideLong-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study.
Fava M, Pani L, De Martin S, Cutler A, Gorodetzky C, Vocci F, Sapienza F, Kosten T, Kröger C, Champasa P, Guidetti C, Comai S, Mattarei A, Folli F, Bushnell D, Traversa S, Inturrisi C, Manfredi P, Pappagallo M. Long-Term Safety and Efficacy of Esmethadone in Patients With Major Depressive Disorder: Findings From a 12-Month Open-Label Study. The Journal Of Clinical Psychiatry 2025, 86 PMID: 39999772, DOI: 10.4088/jcp.24m15438.Peer-Reviewed Original ResearchConceptsDepressive disorderColumbia-Suicide Severity Rating ScaleOpen-label studyDSM-5 criteriaFull analysis setMajor depressive disorderMeasures of depressionSeverity Rating ScaleSexual adverse eventsAntidepressant efficacyTreatment-emergent adverse eventsPostbaseline efficacy assessmentAdverse eventsSuicide attemptsUncompetitive antagonistCognitive functionSafety populationEfficacy assessmentRating ScaleEfficacy measuresMDDDouble-blind studyEmergent adverse eventsLong-term treatmentTreatment-related treatment-emergent adverse eventsPlasma microRNAs to Select Optimal Patients for Antibody Production from Anti-Addiction Vaccines
Kosten T, Koirala A, Nielsen D, Domingo C, Thomas Y, Gunaratne P, Coarfa C. Plasma microRNAs to Select Optimal Patients for Antibody Production from Anti-Addiction Vaccines. Vaccines 2025, 13: 181. PMID: 40006728, PMCID: PMC11860428, DOI: 10.3390/vaccines13020181.Peer-Reviewed Original ResearchDE-miRsAnti-drug antibodiesPlasma microRNAsAnti-addiction vaccinesAnti-cocaine vaccinePotential response biomarkersMiR-150Vaccine trial participantsIllicit amphetamineNon-respondersResponse biomarkersMiRsAntibody respondersAnti-addictiveAntibody levelsAntibody productionStudy predictorsVaccineTrial participantsMicroRNAsCocaineAntibodiesLow ABFalse discovery ratePatientsCELECOXIB ADDED TO RISPERIDONE FOR DEPRESSIVE SYMPTOMS IN FIRST-EPISODE AND DRUG NAÏ VE SCHIZOPHRENIA: PHARMACOGENETIC IMPACT OF BDNF GENE POLYMORPHISMS
Wang *, Chen X, Tian Y, Yu Z, Chen D, Xiu M, Kosten T, Zhang X. CELECOXIB ADDED TO RISPERIDONE FOR DEPRESSIVE SYMPTOMS IN FIRST-EPISODE AND DRUG NAÏ VE SCHIZOPHRENIA: PHARMACOGENETIC IMPACT OF BDNF GENE POLYMORPHISMS. The International Journal Of Neuropsychopharmacology 2025, 28: i158-i159. PMCID: PMC11815116, DOI: 10.1093/ijnp/pyae059.274.Peer-Reviewed Original ResearchHamilton Depression Rating ScaleBrain-derived neurotrophic factorPositive and Negative Syndrome ScaleBrain-derived neurotrophic factor serum levelsBrain-derived neurotrophic factor levelsSchizophrenia patientsTreatment of depressionDepressive symptomsPositive symptomsFirst-episodeSCZ patientsHamilton Depression Rating Scale total scoreBrain-derived neurotrophic factor systemComorbid major depressive disorderTreatment response to antidepressantsTotal scoreEarly stages of schizophreniaBrain-derived neurotrophic factor polymorphismsBrain-derived neurotrophic factor genotypePathogenesis of depressive symptomsBrain-derived neurotrophic factor gene polymorphismImprove treatment of depressionBrain-derived neurotrophic factor signalingHealthy controlsAmerican Journal of Psychiatry