Roger Tieu, MD, PhD
Hospital ResidentCards
About
Research
Publications
2023
Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15
Tieu R, Zeng Q, Zhao D, Zhang G, Feizi N, Manandhar P, Williams A, Popp B, Wood-Trageser M, Demetris A, Tso J, Johnson A, Kane L, Abou-Daya K, Shlomchik W, Oberbarnscheidt M, Lakkis F. Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15. Science Immunology 2023, 8: eadd8454. PMID: 37083450, PMCID: PMC10334460, DOI: 10.1126/sciimmunol.add8454.Peer-Reviewed Original ResearchConceptsAntigen persistenceIL-15Dendritic cellsT cellsAntigen presentationGraft-infiltrating dendritic cellsTissue-resident memory TCognate antigenAbsence of cognate antigenIL-15 transpresentationMemory T cell maintenanceT cell maintenanceChronic transplant rejectionKidney transplant modelIL-15 receptorAcute infection modelMemory TReceptor blockadeChronic rejectionTransplantation modelTransplant rejectionAcute infectionInterleukin-15Allograft pathologySterilizing immunity
2021
Resident memory T cells form during persistent antigen exposure leading to allograft rejection
Abou-Daya K, Tieu R, Zhao D, Rammal R, Sacirbegovic F, Williams A, Shlomchik W, Oberbarnscheidt M, Lakkis F. Resident memory T cells form during persistent antigen exposure leading to allograft rejection. Science Immunology 2021, 6 PMID: 33741656, PMCID: PMC8103522, DOI: 10.1126/sciimmunol.abc8122.Peer-Reviewed Original ResearchConceptsMemory T cellsEffector T cellsT cellsAllograft rejectionAntigen-specificTissue-resident memory T cellsFunctional memory T cellsResident memory T cellsMouse model of kidney transplantationGrafted T cellsPersistent antigen exposureModel of kidney transplantationRenal transplant outcomesRetransplantation experimentsDiscovery of therapeutic targetsExhaustion markersSurface phenotypeAntigen exposureInterferon-gTransplant outcomesKidney transplantationCognate antigenMouse modelOrgan transplantationTransplantation
2020
Formation and function of resident memory t cells in renal allografts
Daya K, Zhao D, Tieu R, Rammal R, Oberbarnscheidt M, Lakkis F. Formation and function of resident memory t cells in renal allografts. The Journal Of Immunology 2020, 204: 161.24-161.24. DOI: 10.4049/jimmunol.204.supp.161.24.Peer-Reviewed Original ResearchOT-IT cellsEndogenous T-cell populationMouse kidney transplant modelOT-I T cellsResident memory T cellsMemory T cellsT cell populationsPreserved kidney functionKidney transplant modelTRM cellsAdoptive transferB6 recipientsTeff cellsChronic rejectionKidney allograftsRe-transplantationRenal allograftsNo significant differenceGraft histologyKidney graftsTransplantation modelBone marrowAllo groupKidney function
2019
Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts
Hughes A, Zhao D, Dai H, Abou-Daya K, Tieu R, Rammal R, Williams A, Landsittel D, Shlomchik W, Morelli A, Oberbarnscheidt M, Lakkis F. Cross-dressed dendritic cells sustain effector T cell responses in islet and kidney allografts. Journal Of Clinical Investigation 2019, 130: 287-294. PMID: 31763998, PMCID: PMC6934226, DOI: 10.1172/jci125773.Peer-Reviewed Original ResearchConceptsHost DCT cell responsesDonor antigensT cellsMHC-peptide complexesActivation of host T cellsAlloantigens to T cellsEffector T cell responsesCD8+ T cellsDonor MHC moleculesHost T cellsDifferentiation to effectorKidney transplant modelSecondary lymphoid organsSelf-MHC moleculesAntigen presentation pathwayAcute rejectionAllograft rejectionDendritic cellsIndirect presentationTransplantation modelAntigen presentationLymphoid organsPresentation pathwayIntravital microscopy
2016
Getting Down and Dirty
Tieu R, Lakkis F, Oberbarnscheidt M. Getting Down and Dirty. Transplantation 2016, 100: 2490-2491. PMID: 27861276, PMCID: PMC5120362, DOI: 10.1097/tp.0000000000001490.Peer-Reviewed Original Research
2014
TIM-3, a Possible Target for Immunotherapy in Cancer and Chronic Viral Infections.
Tieu R, Amancha P, Villinger F, Byrareddy S. TIM-3, a Possible Target for Immunotherapy in Cancer and Chronic Viral Infections. 2014, 1 PMID: 26539564, PMCID: PMC4629856.Peer-Reviewed Original ResearchChronic viral infectionsTim-3Inhibitory receptorsChronic viral infection modelsEffector T cell responsesExpression of Tim-3Viral infectionCo-inhibitory moleculesT cell responsesCTLA-4PD-1Immune checkpointsCo-stimulatorySoluble factorsInfection modelTherapeutic targetImmunotherapyTumorReceptorsInfectionViral infection modelCancerChronicallyComplex mechanismsSystematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes
Luo X, Huang L, Han L, Luo Z, Hu F, Tieu R, Gan L. Systematic Prioritization and Integrative Analysis of Copy Number Variations in Schizophrenia Reveal Key Schizophrenia Susceptibility Genes. Schizophrenia Bulletin 2014, 40: 1285-1299. PMID: 24664977, PMCID: PMC4193716, DOI: 10.1093/schbul/sbu045.Peer-Reviewed Original ResearchConceptsCopy number variationsProtein-protein interactionsSchizophrenia susceptibility genesCandidate genesNumber variationsDisease-common variant hypothesisGlobal overview of genesProportion of missing heritabilityProtein-protein interaction dataSusceptibility genesAnalysis of copy number variationsIntegrated analysis of copy number variationsProtein products of genesIntegration of genesSchizophrenia-associated proteinsProducts of genesOverview of genesSchizophrenia candidate genesSchizophrenia risk genesVariant hypothesisTop genesGenetic heterogeneityFunctional characterizationRisk genesGenetic variants
2013
GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea
Luo X, Deng M, Xie X, Huang L, Wang H, Jiang L, Liang G, Hu F, Tieu R, Chen R, Gan L. GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Human Molecular Genetics 2013, 22: 3609-3623. PMID: 23666531, PMCID: PMC3749857, DOI: 10.1093/hmg/ddt212.Peer-Reviewed Original ResearchConceptsProsensory domainSpiral ganglion neuronsHDR syndromeMouse inner earShortened cochlear ductInner earSensorineural deafnessSurvival of spiral ganglion neuronsCochleovestibular ganglionIncreased cell deathGenetic mapCochlear ductGATA3 functionAuditory system developmentHaplo-insufficiencyCell deathMolecular mechanismsFunctional studiesGanglion neuronsRenal diseaseConditional knockoutGATA3Mouse cochleaNeuronal survivalSyndrome
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