Oriana Ciani, PhD
About
Research
Publications
2025
A Call for Transparency, Improved Reporting and Interpretation of Trials Using Surrogate Endpoints in Cardiac Electrophysiology
Tereshchenko L, Manyara A, Ciani O, Sodeke S, Bradford C, Santangeli P, Kapadia S, Wazni O, Narayan S, Chugh S, Bilchick K, Huizar J, Vaseghi M, Chung M, Ellenbogen K, Taylor R. A Call for Transparency, Improved Reporting and Interpretation of Trials Using Surrogate Endpoints in Cardiac Electrophysiology. Heart Rhythm 2025 PMID: 40021073, DOI: 10.1016/j.hrthm.2025.02.038.Peer-Reviewed Original ResearchSurrogate end pointsConsolidated Standards of Reporting TrialsRandomized controlled trialsEnd pointsCardiac electrophysiologyStandard Protocol ItemsInterpretation of trialsProtocol ItemsClinical trial protocolsConsolidated StandardsReporting TrialsImprove reportingClinical investigationCardiac arrhythmiasSurrogate endpointsReporting guidelinesIntervention trialsConsensus documentTransparent reportingTrial protocolChecklistHistorical examplesElectrophysiologyTrialsParadoxShared Decision-making
Ciani O, Ardito V, Oprea N. Shared Decision-making. 2025, 445-454. DOI: 10.1201/9781003390855-24.Peer-Reviewed Original Research
2024
Surrogate endpoints in randomised trials of physiotherapy interventions: the SPIRIT and CONSORT extension checklists for better reporting
Faria C, Polese J, Manyara A, Taylor R, Ciani O, Scianni A. Surrogate endpoints in randomised trials of physiotherapy interventions: the SPIRIT and CONSORT extension checklists for better reporting. Journal Of Physiotherapy 2024, 71: 1-3. PMID: 39690082, DOI: 10.1016/j.jphys.2024.11.013.Peer-Reviewed Original ResearchHPR99 Does HTA Undermine the Goals of EMA Authorization Pathways? Time to Availability of Drugs Licensed Under Conditional Marketing Authorization Compared to Standard Marketing Authorization
Ardito V, Robinson J, Ciani O. HPR99 Does HTA Undermine the Goals of EMA Authorization Pathways? Time to Availability of Drugs Licensed Under Conditional Marketing Authorization Compared to Standard Marketing Authorization. Value In Health 2024, 27: s294. DOI: 10.1016/j.jval.2024.10.1525.Peer-Reviewed Original ResearchPCR1 The Development of a Comprehensive Repository of Patient-Reported Outcome Measures (PROMs) for Spinal Muscular Atrophy and Duchenne Muscular Dystrophy
Malandrini F, Meregaglia M, Spataro C, D'amico A, Sansone V, Scopinaro A, Ciani O. PCR1 The Development of a Comprehensive Repository of Patient-Reported Outcome Measures (PROMs) for Spinal Muscular Atrophy and Duchenne Muscular Dystrophy. Value In Health 2024, 27: s503. DOI: 10.1016/j.jval.2024.10.3236.Peer-Reviewed Original ResearchOP09 Investigating The Nature And Scope Of Innovative Payment And Pricing Schemes For Health Technologies
Ardito V, Cavallaro L, Drummond M, Ciani O. OP09 Investigating The Nature And Scope Of Innovative Payment And Pricing Schemes For Health Technologies. International Journal Of Technology Assessment In Health Care 2024, 40: s5-s5. PMCID: PMC11719172, DOI: 10.1017/s0266462324000734.Peer-Reviewed Original ResearchHealth technology assessmentHealth technologiesWeb of ScienceNested evaluationInnovation paymentsSystematic reviewStudy protocolTechnology assessmentHealthImplementation challengesData collection needsAgency websitesExpenditure capsAffordability issuesPayment schemeProduct categoriesPricing schemeDistribution of riskCollection needsPricePROSPEROReimbursementValue Attribution for Combination Treatments: Two Potential Solutions for an Insoluble Problem
Ciani O, Jommi C. Value Attribution for Combination Treatments: Two Potential Solutions for an Insoluble Problem. Value In Health 2024, 28: 70-71. PMID: 39581497, DOI: 10.1016/j.jval.2024.11.002.Peer-Reviewed Original ResearchCorrection: Outcomes of Patients With Early and Locally Advanced Lung Cancer: Protocol for the Italian Lung Cancer Observational Study (LUCENT)
Bertolaccini L, CIani O, Lucchi M, Zaraca F, Bertani A, Crisci R, Spaggiari L, Group L. Correction: Outcomes of Patients With Early and Locally Advanced Lung Cancer: Protocol for the Italian Lung Cancer Observational Study (LUCENT). JMIR Research Protocols 2024, 13: e67629. PMID: 39471369, PMCID: PMC11558210, DOI: 10.2196/67629.Peer-Reviewed Original ResearchAssessing the long-term prognostic ability of the 70 gene expression signature MammaPrint in an Italian single-center prospective cohort study of early-stage intermediate-risk breast cancer patients
Generali D, Rocca A, Strina C, Milani M, Fiorino E, Cervoni V, Azzini C, Saracino A, Ciliberto I, Ziglioli N, Alberio M, Giudici F, Dester M, Ciani O, Fornaro G, Aguggini S, Dreezen C, Pronin D, Ende S. Assessing the long-term prognostic ability of the 70 gene expression signature MammaPrint in an Italian single-center prospective cohort study of early-stage intermediate-risk breast cancer patients. Heliyon 2024, 10: e39485. PMID: 39553665, PMCID: PMC11564935, DOI: 10.1016/j.heliyon.2024.e39485.Peer-Reviewed Original ResearchLow-risk tumorsHigh-risk tumorsRisk tumorsOverall survivalBreast cancerFollow-upPrognostic performanceHigh-risk BC patientsIntermediate-risk breast cancerLong-term prognostic abilitySingle-center prospective cohort studyPathologic tumor characteristicsProgesterone receptor-positiveSingle-center prospective cohortMedian follow-upBreast cancer patientsGenomic riskProspective cohort studyCox regression modelsPersonalize treatment choicesNodal statusReceptor statusReceptor-positiveTumor characteristicsTumor sizeDesign and Features of Pricing and Payment Schemes for Health Technologies: A Scoping Review and a Proposal for a Flexible Need-Driven Classification
Ardito V, Ciani O, Drummond M. Design and Features of Pricing and Payment Schemes for Health Technologies: A Scoping Review and a Proposal for a Flexible Need-Driven Classification. PharmacoEconomics 2024, 43: 5-29. PMID: 39405025, PMCID: PMC11724778, DOI: 10.1007/s40273-024-01435-2.Peer-Reviewed Original ResearchHealth technologiesPreferred Reporting ItemsGroups of keywordsMethodsA Preferred Reporting ItemsScoping reviewDecision makersReporting ItemsIndependent reviewersOutcome componentsSystematic reviewPayment schemeNarrative formatSchemeComprehensive categorizationCollection requirementsProblem of affordabilityHealthClassificationFeatures of pricing
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