Mihir Gupta, MD
Assistant ProfessorCards
About
Research
Publications
2026
1173 Multi-Institutional Assessment of Circulating Cell-Free DNA in CSF Facilitates CNS Lymphoma Diagnosis and Treatment Initiation
Prager B, Gupta M, West T, Ramundo C, Bagin J, Filho L, Georgantas N, Pilacky R, Forst D, Jordan J, Mansouri A, Carter B, Cahill D, Nahed B, Dietrich J, Wang C, Shankar G. 1173 Multi-Institutional Assessment of Circulating Cell-Free DNA in CSF Facilitates CNS Lymphoma Diagnosis and Treatment Initiation. Neurosurgery 2026, 72: 228-228. DOI: 10.1227/neu.0000000000003964_1173.Peer-Reviewed Original Research
2025
Multi-Institutional Assessment of Circulating Cell-Free DNA in Cerebrospinal Fluid Facilitates Central Nervous System Lymphoma Diagnosis and Treatment Initiation.
Prager B, Gupta M, West T, Ramundo C, Bagin J, de Macedo Filho L, Georgantas N, Pilacky R, Forst D, Jordan J, Mansouri A, Carter B, Cahill D, Nahed B, Dietrich J, Wang C, Shankar G. Multi-Institutional Assessment of Circulating Cell-Free DNA in Cerebrospinal Fluid Facilitates Central Nervous System Lymphoma Diagnosis and Treatment Initiation. Neurosurgery 2025 PMID: 41190874, DOI: 10.1227/neu.0000000000003835.Peer-Reviewed Original ResearchDiagnosis of CNS lymphomaCentral nervous system lymphomaCell-free DNACentral nervous systemMYD88 L265PTissue biopsiesPolymerase chain reactionCNS lymphomaRisk of neurological morbidityCentral nervous system biopsyDiagnosis of central nervous systemTime to treatmentCerebrospinal fluid analysisMulti-institutional assessmentTissue confirmationLymphoma diagnosisClinical responseClinical courseNeurological morbidityDiagnostic yieldTreatment initiationProspective cohortLiquid biopsyLymphomaBiopsyTargeting sickle cell pathobiology and pain with novel transdermal curcumin
Goel Y, Arellano M, Fouda R, Garcia N, Lomeli R, Kerr D, Argueta D, Gupta M, Velasco G, Prince R, Banerjee P, Jana S, Alayash A, Friedman J, Gupta K. Targeting sickle cell pathobiology and pain with novel transdermal curcumin. PNAS Nexus 2025, 4: pgaf053. PMID: 40007577, PMCID: PMC11854080, DOI: 10.1093/pnasnexus/pgaf053.Peer-Reviewed Original ResearchSickle cell diseaseRed blood cellsInflammatory consequencesGranulocyte-macrophage colony-stimulating factorGel formulationMonocyte chemoattractant protein-1Blood cellsNormal T-cellColony-stimulating factorSickle cell miceChemoattractant protein-1Consequences of sickle cell diseaseMast cell degranulationPain hypersensitivityChronic administrationChronic painT cellsCost-effective therapeuticsCell miceProinflammatory cytokinesChronic inflammationInterleukin-6Red blood cell stabilityOral administrationCell diseaseSomatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas
Gupta M, Samiappan S, Alanya H, Yalcin K, Gultekin B, Sharaf R, Elsamadicy A, Figuera D, Samuel N, Mishra-Gorur K, Kolb L, McGuone D, Gunel M, Erson-Omay E, Moliterno J, Mendel E. Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas. Neuro-Oncology Advances 2025, 7: vdaf067. PMID: 40386121, PMCID: PMC12081948, DOI: 10.1093/noajnl/vdaf067.Peer-Reviewed Original Research
2024
Rapid Tumor DNA Analysis of Cerebrospinal Fluid Accelerates Treatment of Central Nervous System Lymphoma.
Gupta M, Bradley J, Massaad E, Burns E, Georgantas NZ, Maron G, Batten J, Gallagher A, Thierauf J, Nayyar N, Gordon A, Jones S, Pisapia M, Sun Y, Jones PS, Barker FG 2nd, Curry W, Gupta R, Romero J, Wang N, Brastianos P, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Iser F, Kessler T, Jordan JT, Dietrich J, Meyerson ML, Cahill DP, Lennerz JK, Carter B, Shankar GM. Rapid Tumor DNA Analysis of Cerebrospinal Fluid Accelerates Treatment of Central Nervous System Lymphoma. Blood 2024 PMID: 38776489, DOI: 10.1182/blood.2024023832.Peer-Reviewed Original ResearchRadical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma
Massaad E, Smith W, Bradley J, Esposito E, Gupta M, Burns E, Burns R, Velarde J, Berglar I, Gupta R, Martinez-Lage M, Dietrich J, Lennerz J, Dunn G, Jones P, Choi B, Kim A, Frosch M, Barker F, Curry W, Carter B, Nahed B, Cahill D, Shankar G. Radical surgical resection with molecular margins is associated with improved survival in IDH wild-type glioblastoma. Neuro-Oncology 2024, 26: 1660-1669. PMID: 38581292, PMCID: PMC11376447, DOI: 10.1093/neuonc/noae073.Peer-Reviewed Original ResearchConceptsGross-total resectionSurgical marginsSurgical resectionMolecular marginsTERT mutationsDetection of TERT promoter mutationsResidual volumeTERT promoter mutation analysisIDH wild-type glioblastomaLocal control benefitRadical surgical resectionTERT promoter mutationsTumor cell contentIDH wild-typeWild-type glioblastomaArea under the curveMonths follow-upPromoter mutation analysisResection marginsTumor burdenRadical resectionTumor anatomyResection strategyFollow-upResection
2023
Gender diversity at spine surgery academic conferences: a 15-year investigation.
Cartagena-Reyes MA, Gupta M, Roy JM, Solomon E, Yenokyan G, Fogam L, Nazario-Ferrer GI, ElNemer WG, Park S, Skolasky RL Jr, Jain A. Gender diversity at spine surgery academic conferences: a 15-year investigation. Spine J 2023 PMID: 38081462, DOI: 10.1016/j.spinee.2023.11.018.Peer-Reviewed Original ResearchHuman microglia maturation is underpinned by specific gene regulatory networks.
Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA, Birth Defects Research Laboratory, Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. Human microglia maturation is underpinned by specific gene regulatory networks. Immunity 2023, 56: 2152-2171.e13. PMID: 37582369, DOI: 10.1016/j.immuni.2023.07.016.Peer-Reviewed Original ResearchA new era dawns on sickle cell disease in India.
Kishore RR, Gupta M, Gupta K. A new era dawns on sickle cell disease in India. Indian J Med Res 2023, 157: 491-493. PMID: 37530303, DOI: 10.4103/ijmr.ijmr_1045_23.Peer-Reviewed Original Research380 A Rapid CSF Assay Accelerates Diagnosis and Treatment Initiation for CNS Neoplasms
Gupta M, Bradley J, Massaad E, Burns E, Forst D, Cahill D, Barker F, Jordan J, Dietrich J, Lennerz J, Nahed B, Carter B, Shankar G. 380 A Rapid CSF Assay Accelerates Diagnosis and Treatment Initiation for CNS Neoplasms. Neurosurgery 2023, 69: 67-67. DOI: 10.1227/neu.0000000000002375_380.Peer-Reviewed Original ResearchCNS neoplasmsCNS lymphomaBrainstem gliomasNeurosurgical biopsyCases of CNS lymphomaCell-free DNA panelH3K27M-mutant diffuse midline gliomaDiffuse midline gliomaHigh-risk lesionsDay of admissionDisease-directed therapyH3K27M-mutantRituximab initiationIDH inhibitorsMYD88 mutationsRadiographic responseComparison to casesRadiation therapyMidline gliomaTERT promoterCSF studiesTreatment initiationTreatment responseCNS neoplasiaClinical decision-making
Academic Achievements & Community Involvement
Clinical Care
Overview
Mihir Gupta, MD, is a fellowship-trained spine surgeon with a background in neurosurgery and orthopaedics. He performs both traditional and minimally invasive procedures to treat an array of complex spinal disorders.
Dr. Gupta says he was drawn to spine surgery because of how quickly the field is evolving. “We finally have a much better understanding of why people have back or neck pain and how to make it better safely,” he says. “And that doesn’t always involve surgery. Our job is to figure out when surgery is appropriate, and more importantly, when it is not the best solution.”
Dr. Gupta treats a variety of spine conditions including those that are degenerative, deformative, or the result of tumors, infections, or trauma. He also performs revision spine surgeries, or surgeries for people who have had surgery in the past but have a persistent or new problem.
Before he walks in the exam room and meets a new patient, Dr. Gupta says he likes to do his homework and look through any imaging studies they brought. “That way, I can focus on listening to them and doing a very thorough physical exam,” he says. “A thoughtful evaluation and really good physical exam are vital for making an accurate diagnosis. Often, I think patients haven’t had their problem explained in a way that makes sense to them, and I prioritize that.”
Spine procedures, Dr. Gupta says, are highly personalized. “There isn’t a one-size-fits-all approach. Our diagnostics have come so far that we have better imaging that allows us to see where pain is coming from and if surgery is needed,” Dr. Gupta says. “We also have better tools now with robotics and navigation and minimally invasive methods. These all allow us to tailor the right solution for them.”
Surgery, he points out, is often the last resort and, in some cases, is not the right solution for a patient’s pain. “We work closely with the pain management team, anesthesiology, physical therapists, and interventional radiologists to come up with nonsurgical options,” he says.
Dr. Gupta’s research interests include understanding how genetics contribute to different spinal disorders and how care can be personalized.
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Minimally Invasive Spinal Surgery
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