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Mihir Gupta, MD

Assistant Professor
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Assistant Professor

Biography

Dr. Mihir Gupta is a fellowship-trained spine surgeon and assistant professor of neurosurgery. After graduating from Stanford University, he completed neurosurgical residency at the University of California San Diego, postdoctoral studies at Harvard Medical School, and orthopedic spine surgery fellowship at Johns Hopkins University. With a background in both neurosurgery and orthopedics, he performs a variety of traditional as well as minimally invasive procedures for a variety of complex spinal disorders. Dr. Gupta prioritizes understanding each patient's unique and detailed story. He works closely with physical therapists, pain specialists and physiatrists to offer personalized surgical and non-surgical treatments.

Last Updated on December 20, 2023.

Appointments

Other Departments & Organizations

Education & Training

Fellow, Complex Spine Surgery
Johns Hopkins University
Resident Physician
University of California San Diego
Postdoctoral Fellow
Massachusetts General Hospital
MD
Stanford University School of Medicine
BA
Harvard College

Research

Research at a Glance

Yale Co-Authors

Frequent collaborators of Mihir Gupta's published research.

Publications

2025

2024

2023

  • Human microglia maturation is underpinned by specific gene regulatory networks.
    Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA, Birth Defects Research Laboratory, Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. Human microglia maturation is underpinned by specific gene regulatory networks. Immunity 2023, 56: 2152-2171.e13. PMID: 37582369, DOI: 10.1016/j.immuni.2023.07.016.
    Peer-Reviewed Original Research
  • Cerebrospinal Fluid Genotyping Accelerates Brain Tumor Patient Treatment
    Gupta M, Bradley JD, Massaad E, Burns EJ, Georgantas NZ, Maron GE, Thierauf J, Nayyar N, Gordon A, Jones SS, Pisapia M, Sun Y, Jones PS, Barker FG, Curry WT, Gupta R, Romero JM, Wang N, Brastianos PK, Martinez-Lage M, Tateishi K, Forst DA, Nahed BV, Batchelor TT, Ritterhouse LL, Jordan JT, Dietrich J, Meyerson M, Cahill DP, Lennerz JK, Carter BS, Shankar GM. [under review]
    Peer-Reviewed Original Research

2022

2021

  • A rapid genotyping panel for detection of primary central nervous system lymphoma.
    Gupta M, Burns EJ, Georgantas NZ, Thierauf J, Nayyar N, Gordon A, Jones SS, Pisapia M, Sun Y, Burns RP, Velarde J, Jordan JT, Frigault MJ, Nahed BV, Jones PS, Barker FG, Curry WT, Gupta R, Batchelor TT, Romero JM, Brastianos PK, Marble HD, Martinez-Lage M, Tateishi K, Lennerz JK, Dietrich J, Cahill DP, Carter BS, Shankar GM. A rapid genotyping panel for detection of primary central nervous system lymphoma. Blood 2021, 138: 382-386. PMID: 33735913, DOI: 10.1182/blood.2020010137.
    Peer-Reviewed Original Research

Clinical Care

Overview

Mihir Gupta, MD, is a fellowship-trained spine surgeon with a background in neurosurgery and orthopaedics. He performs both traditional and minimally invasive procedures to treat an array of complex spinal disorders.

Dr. Gupta says he was drawn to spine surgery because of how quickly the field is evolving. “We finally have a much better understanding of why people have back or neck pain and how to make it better safely,” he says. “And that doesn’t always involve surgery. Our job is to figure out when surgery is appropriate, and more importantly, when it is not the best solution.”

Dr. Gupta treats a variety of spine conditions including those that are degenerative, deformative, or the result of tumors, infections, or trauma. He also performs revision spine surgeries, or surgeries for people who have had surgery in the past but have a persistent or new problem.

Before he walks in the exam room and meets a new patient, Dr. Gupta says he likes to do his homework and look through any imaging studies they brought. “That way, I can focus on listening to them and doing a very thorough physical exam,” he says. “A thoughtful evaluation and really good physical exam are vital for making an accurate diagnosis. Often, I think patients haven’t had their problem explained in a way that makes sense to them, and I prioritize that.”

Spine procedures, Dr. Gupta says, are highly personalized. “There isn’t a one-size-fits-all approach. Our diagnostics have come so far that we have better imaging that allows us to see where pain is coming from and if surgery is needed,” Dr. Gupta says. “We also have better tools now with robotics and navigation and minimally invasive methods. These all allow us to tailor the right solution for them.”

Surgery, he points out, is often the last resort and, in some cases, is not the right solution for a patient’s pain. “We work closely with the pain management team, anesthesiology, physical therapists, and interventional radiologists to come up with nonsurgical options,” he says.

Dr. Gupta’s research interests include understanding how genetics contribute to different spinal disorders and how care can be personalized.

Clinical Specialties

Neurosurgery

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