Liang Li
Associate Research ScientistDownloadHi-Res Photo
About
Titles
Associate Research Scientist
Departments & Organizations
Education & Training
- Postdoctoral fellow
- University of California, San Francisco (2024)
- PhD
- Peking Union Medical College, Biochemistry& Molecular Biology (2018)
Research
Overview
Adipose tissue has important implications for metabolism and general health. Enhancing energy utilization by increasing the number and activity of beige adipocytes, an inducible form of thermogenic fat cells, can be of therapeutic benefit for a broad range of metabolic disorders.
My research focuses on understanding how thermogenic fat cells are created in vivo and what determines their metabolic phenotypes under physiological and pathological conditions. I'm also interested in exploring the application and utility of adipose tissue preclinical model in anti-obesity drug discovery.
In the long term, the goal is to use our understanding of the thermogenic fat cells development to guide strategies for expanding metabolically beneficial adipocyte phenotypes for the treatment of obesity and metabolic disease.
Research at a Glance
Publications Timeline
A big-picture view of Liang Li's research output by year.
8Publications
Publications
2024
White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models.
Li L, Feldman BJ. White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models. J Clin Invest 2024, 134 PMID: 38949025, DOI: 10.1172/JCI172360.Peer-Reviewed Original Research
2023
Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown.
Li L, Gunewardena AM, Nyima T, Feldman BJ. Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown. STAR Protoc 2023, 4: 102607. PMID: 37742183, DOI: 10.1016/j.xpro.2023.102607.Peer-Reviewed Original ResearchIdentification of an adipose tissue-resident pro-preadipocyte population.
Chen M, Kim S, Li L, Chattopadhyay S, Rando TA, Feldman BJ. Identification of an adipose tissue-resident pro-preadipocyte population. Cell Rep 2023, 42: 112440. PMID: 37119138, DOI: 10.1016/j.celrep.2023.112440.Peer-Reviewed Original Research
2021
MYH9 facilitates autoregulation of adipose tissue depot development.
Cheung SY, Sayeed M, Nakuluri K, Li L, Feldman BJ. MYH9 facilitates autoregulation of adipose tissue depot development. JCI Insight 2021, 6 PMID: 33986190, DOI: 10.1172/jci.insight.136233.Peer-Reviewed Original Research
2019
PTB-AS, a Novel Natural Antisense Transcript, Promotes Glioma Progression by Improving PTBP1 mRNA Stability with SND1.
Zhu L, Wei Q, Qi Y, Ruan X, Wu F, Li L, Zhou J, Liu W, Jiang T, Zhang J, Yin B, Yuan J, Qiang B, Han W, Peng X. PTB-AS, a Novel Natural Antisense Transcript, Promotes Glioma Progression by Improving PTBP1 mRNA Stability with SND1. Mol Ther 2019, 27: 1621-1637. PMID: 31253583, DOI: 10.1016/j.ymthe.2019.05.023.Peer-Reviewed Original ResearchThe COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling.
Li L, Ruan X, Wen C, Chen P, Liu W, Zhu L, Xiang P, Zhang X, Wei Q, Hou L, Yin B, Yuan J, Qiang B, Shu P, Peng X. The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Cell Rep 2019, 28: 698-711.e5. PMID: 31315048, DOI: 10.1016/j.celrep.2019.06.055.Peer-Reviewed Original Research In Press
2018
Generating a reporter mouse line marking medium spiny neurons in the developing striatum driven by Arpp21 cis-regulatory elements.
Chen P, Ruan X, Chen Y, Chu S, Mo K, Wu C, Liu W, Yin B, Zhou J, Li L, Hou L, Yuan J, Qiang B, Chen J, Shu P, Peng X. Generating a reporter mouse line marking medium spiny neurons in the developing striatum driven by Arpp21 cis-regulatory elements. J Genet Genomics 2018, 45: 673-676. PMID: 30595471, DOI: 10.1016/j.jgg.2018.09.007.Peer-Reviewed Original ResearchMutation of the cellular adhesion molecule NECL2 is associated with neuromyelitis optica spectrum disorder.
Xu Y, Li L, Ren HT, Yin B, Yuan JG, Peng XZ, Qiang BQ, Cui LY. Mutation of the cellular adhesion molecule NECL2 is associated with neuromyelitis optica spectrum disorder. J Neurol Sci 2018, 388: 133-138. PMID: 29627007, DOI: 10.1016/j.jns.2017.10.023.Peer-Reviewed Case Reports and Technical Notes