Katie Tiemeyer
About
Biography
Katie is an MD-PhD student from Athens, Georgia with a strong interest in the glycobiological mechanisms that drive disease. Katie completed her undergraduate education at Boston University where she earned degrees in Biochemistry and Molecular Biology (BA, with Honors) and Vocal Performance (BM). While at BU, Katie completed her undergraduate research thesis in the lab of Kim McCall, where she interrogated the glycosylation state of a glial phagocytosis receptor in Drosophila. She also contributed to characterization of the mechanisms by which defective glial phagocytosis begets age-dependent neurodegeneration in Drosophila.
After graduating in 2021, Katie accepted a position in the lab of Carolyn Bertozzi at Stanford University where she worked closely with a physician-scientist to develop the first total glycosylation profile of the human platelet protein GPIb alpha. At Yale, Katie hopes to leverage her background in glycobiology to explore the roles of glycans in human disease, with a special interest in understanding the pathogenic consequences of altered protein glycosylation in cancer and neurodegenerative disease.
Outside of science and medicine, Katie sings with the Yale Schola Cantorum and enjoys playing piano, knitting/crocheting, and fostering kittens.
Education & Training
- Life Science Research Professional
- Stanford University (2023)
- BA
- Boston University, Biochemistry and Molecular Biology (2021)
- BM
- Boston University, Vocal Performance (2021)
Research
Research at a Glance
Yale Co-Authors
Stacy Malaker
Publications
2023
New insights into the glycobiology of immune thrombocytopenia.
Tiemeyer KH, Kuter DJ, Cairo CW, Hollenhorst MA. New insights into the glycobiology of immune thrombocytopenia. Curr Opin Hematol 2023 PMID: 37526945, DOI: 10.1097/MOH.0000000000000781.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGlycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE.
Chongsaritsinsuk J, Steigmeyer AD, Mahoney KE, Rosenfeld MA, Lucas TM, Ince D, Kearns FL, Battison AS, Hollenhorst MA, Shon DJ, Tiemeyer KH, Attah V, Kwon C, Bertozzi CR, Ferracane MJ, Amaro RE, Malaker SA. Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE. BioRxiv 2023 PMID: 36778266, DOI: 10.1101/2023.02.01.526488.Peer-Reviewed Original Research In PressComprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation
Hollenhorst M, Tiemeyer K, Mahoney K, Aoki K, Ishihara M, Lowery S, Rangel-Angarita V, Bertozzi C, Malaker S. Comprehensive analysis of platelet glycoprotein Ibα ectodomain glycosylation. Journal Of Thrombosis And Haemostasis 2023, 21: 995-1009. PMID: 36740532, PMCID: PMC10065957, DOI: 10.1016/j.jtha.2023.01.009.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsO-glycositesGPIb-IX-V complexMajor ligand-binding subunitAmino acid sitesLigand-binding subunitVon Willebrand factor bindingPlatelet glycoprotein IbαMechanosensory domainFactor bindingEndogenous proteinsRecombinant proteinsN-glycositesStructural rolePlatelet biologyGlycan structuresGlycoprotein IbαO-glycansT antigenGlycosylation profileDiverse repertoireGlycosylationGlycansComprehensive analysisGlycositesVon Willebrand factorDefective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling.
Elguero JE, Liu G, Tiemeyer K, Gandevia H, Duro L, McCall K. Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling. BioRxiv 2023 PMID: 36711924, DOI: 10.1101/2023.01.08.523170.Peer-Reviewed Original Research In Press
2017
COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes.
Frappaolo A, Sechi S, Kumagai T, Robinson S, Fraschini R, Karimpour-Ghahnavieh A, Belloni G, Piergentili R, Tiemeyer KH, Tiemeyer M, Giansanti MG. COG7 deficiency in Drosophila generates multifaceted developmental, behavioral and protein glycosylation phenotypes. J Cell Sci 2017, 130: 3637-3649. PMID: 28883096, DOI: 10.1242/jcs.209049.Peer-Reviewed Original Research