J. Nicholas Fisk
About
Research
Publications
2022
Not only mutations but also tumorigenesis can be substantially attributed to DNA damage from reactive oxygen species in RUNX1::RUNX1T1-fusion-positive acute myeloid leukemia
Mandell J, Fisk J, Cyrenne E, Xu M, Cannataro V, Townsend J. Not only mutations but also tumorigenesis can be substantially attributed to DNA damage from reactive oxygen species in RUNX1::RUNX1T1-fusion-positive acute myeloid leukemia. Leukemia 2022, 36: 2931-2933. PMID: 36369483, PMCID: PMC9712081, DOI: 10.1038/s41375-022-01752-5.Peer-Reviewed Original ResearchWhy are keratins important?
Fisk J, Nebert D. Why are keratins important? Human Genomics 2022, 16: 4. PMID: 35094700, PMCID: PMC8801120, DOI: 10.1186/s40246-022-00379-y.Peer-Reviewed Original ResearchUpdate of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders
Ho M, Thompson B, Fisk JN, Nebert DW, Bruford EA, Vasiliou V, Bunick CG. Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Human Genomics 2022, 16: 1. PMID: 34991727, PMCID: PMC8733776, DOI: 10.1186/s40246-021-00374-9.Peer-Reviewed Original ResearchConceptsTissue-specific expression patternsKeratin genesExpression patternsHuman disease-causing variantsType II keratin genesGenotype-Tissue Expression (GTEx) projectIntermediate filament genesKeratin gene familyEarly metazoan evolutionGene expression patternsAmphibian genomesZebrafish genomeAnimal genomesParalogous proteinsMetazoan evolutionGene expansionChromosome 17q21.2Gene familyFilament genesSpecies survivalDivergent functionsExpression projectChromosomal segmentsChr 11Chr 15
2021
Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma
Fisk JN, Mahal AR, Dornburg A, Gaffney SG, Aneja S, Contessa JN, Rimm D, Yu JB, Townsend JP. Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma. Cancer Letters 2021, 526: 346-351. PMID: 34780851, PMCID: PMC8702484, DOI: 10.1016/j.canlet.2021.11.011.Peer-Reviewed Original ResearchConceptsMutational processesSingle ancestral lineageAncestral lineageProgression of cancerMetastatic lineagesPhylogenetic analysisGenetic resistanceEvolutionary processesExogenous mutational processesCancer evolutionConsolidative therapyMutational signature analysisEGFR-positive non-small cell lung cancerNon-small cell lung cancerKey eventsLineagesCell populationsTherapeutic resistanceLocal consolidative therapyClinical time courseCell lung cancerDisease etiologyTherapeutic decision makingCisplatin therapyLung cancerRNA-Seq analysis of genes involved in pistillate flower initiation in Carya illinoinensis
Rhein H, Barnes S, Van Scyoc B, Fisk J, Song M, Thompson M, Heerema R, Randall J. RNA-Seq analysis of genes involved in pistillate flower initiation in Carya illinoinensis. Acta Horticulturae 2021, 157-164. DOI: 10.17660/actahortic.2021.1318.24.Peer-Reviewed Original ResearchInsights into the impact of geography and genetics on the microbiome of Carya illinoinensis
Randall J, Cervantes K, Ray D, Sanchez A, Mason K, Fisk J, Soneji J, Sanchez L, Grauke L, Wang X. Insights into the impact of geography and genetics on the microbiome of Carya illinoinensis. Acta Horticulturae 2021, 235-240. DOI: 10.17660/actahortic.2021.1318.34.Peer-Reviewed Original ResearchRNA-Seq analysis of genes involved in pistillate flower initiation in Carya illinoinensis
Rhein, H., Barnes, S., Van Scyoc, B., Fisk, J.N., Song Mingzhou, Thompson, M., Heerema, R. and Randall, J. (2021). RNA-Seq analysis of genes involved in pistillate flower initiation in Carya illinoinensis. Acta Hortic. 1318, 157-164 DOI: 10.17660/ActaHortic.2021.1318.24Peer-Reviewed Original ResearchInsights into the impact of geography and genetics on the microbiome of Carya illinoinensis
Randall, J., Cervantes, K., Ray, D.K., Sanchez, A., Mason, K., Fisk, J.N., Soneji, J.R., Sanchez, L., Grauke, L.J. and Wang, X. (2021). Insights into the impact of geography and genetics on the microbiome of Carya illinoinensis. Acta Hortic. 1318, 235-240 DOI: 10.17660/ActaHortic.2021.1318.34Peer-Reviewed Original Research
2019
Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation
Austin JW, Buckner CM, Kardava L, Wang W, Zhang X, Melson VA, Swanson RG, Martins AJ, Zhou JQ, Hoehn KB, Fisk JN, Dimopoulos Y, Chassiakos A, O'Dell S, Smelkinson MG, Seamon CA, Kwan RW, Sneller MC, Pittaluga S, Doria-Rose NA, McDermott A, Li Y, Chun TW, Kleinstein SH, Tsang JS, Petrovas C, Moir S. Overexpression of T-bet in HIV infection is associated with accumulation of B cells outside germinal centers and poor affinity maturation. Science Translational Medicine 2019, 11 PMID: 31776286, PMCID: PMC7479651, DOI: 10.1126/scitranslmed.aax0904.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, NeutralizingAntibody AffinityAntigens, CD19B-LymphocytesCytokinesFemaleGerminal CenterHIV InfectionsHumansImmunologic MemoryLymph NodesMaleMiddle AgedMutation RatePhenotypeReceptors, Antigen, B-CellT-Box Domain ProteinsT-Lymphocytes, Helper-InducerTranscriptomeYoung AdultConceptsHIV-specific B cellsT-betGC B cellsGerminal centersB cellsLymph nodesPoor affinity maturationChronic immune activationMemory B cell compartmentAntibody-mediated immunityChronic infectious diseaseOptimal antibody responseB cell compartmentChronic human infectionsB cell receptorHIV viremiaImmunologic outcomesHIV infectionViremic individualsChronic viremiaImmune activationPeripheral bloodProtective antibodiesAntibody responseCD19
2017
p53 binding sites in normal and cancer cells are characterized by distinct chromatin context
Bao F, LoVerso PR, Fisk JN, Zhurkin VB, Cui F. p53 binding sites in normal and cancer cells are characterized by distinct chromatin context. Cell Cycle 2017, 16: 2073-2085. PMID: 28820292, PMCID: PMC5731425, DOI: 10.1080/15384101.2017.1361064.Peer-Reviewed Original ResearchConceptsP53 binding siteHistone marksTranscription factorsDNA-binding transcription factorsP53 sitesCancer cellsRepressive histone marksContext of chromatinActive histone marksDistinct epigenetic featuresPioneer transcription factorsHigh nucleosome occupancyP53-DNA interactionsEndogenous retroviral elementsBinding sitesSequence-dependent mannerChromatin environmentChromatin contextNucleosome occupancyTranscriptional networksRepeat familyCognate sitesDNA methylationEpigenetic featuresP53 interacts