Jae Woong Lee, MD
Clinical FellowCards
About
Research
Publications
2022
Leadership roles and initiatives for diversity and inclusion in academic anesthesiology departments
Brooks AK, Liang Y, Brooks M, Lee JW, Zhang X, Nwangwu I, Eltzschig HK, Nwokolo OO. Leadership roles and initiatives for diversity and inclusion in academic anesthesiology departments. Journal Of The National Medical Association 2022, 114: 147-155. PMID: 35065814, DOI: 10.1016/j.jnma.2021.12.014.Peer-Reviewed Original Research
2021
PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling
Li J, Conrad C, Mills T, Berg N, Kim B, Ruan W, Lee J, Zhang X, Yuan X, Eltzschig H. PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling. Journal Of Experimental Medicine 2021, 218: e20210008. PMID: 33891683, PMCID: PMC8077173, DOI: 10.1084/jem.20210008.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryMyocardial ischemia-reperfusion injuryNetrin-1Cardiac ischemia-reperfusion injuryNetrin-1 levelsGuidance molecule netrin-1Blood of patientsAdenosine A2B receptorTissue-specific sourceRecombinant netrin-1Adenosine A2BNeutrophil depletionTroponin levelsIschemic insultInfarct sizeMyocardial injuryMyocardial infarctionTissue injuryPharmacologic studiesFunctional roleA2B receptorsInjuryVivo studiesMiceTissue compartments
2020
Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion.
Lee J, Koeppen M, Seo S, Bowser J, Yuan X, Li J, Sibilia M, Ambardekar A, Zhang X, Eckle T, Yoo S, Eltzschig H. Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion. Anesthesiology 2020, 132: 763-780. PMID: 31794514, PMCID: PMC7072004, DOI: 10.1097/aln.0000000000003037.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor 2AReperfusion injuryMyocardial ischemiaErbB1 expressionTranscription-independent inductionGrowth factorEpidermal growth factorFactor 2AIschemic heart disease patientsMyocardial tissueRole of ErbB1Larger infarct sizeIschemic heart diseaseHeart disease patientsNormal control patientsReceptor 1 expressionMyocardial ischemia toleranceHypoxia-inducible factorHuman myocardial tissueControl patientsInfarct sizeDisease patientsHeart diseaseIschemiaKnockout mice
2019
Hypoxia signaling in human diseases and therapeutic targets
Lee J, Ko J, Ju C, Eltzschig H. Hypoxia signaling in human diseases and therapeutic targets. Experimental & Molecular Medicine 2019, 51: 1-13. PMID: 31221962, PMCID: PMC6586801, DOI: 10.1038/s12276-019-0235-1.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorNovel therapeutic optionsChronic disease conditionsDifferent organ systemsDownstream targetsOrgan injuryTherapeutic optionsTherapeutic targetOrgan systemsHIF stabilizationHypoxiaDisease conditionsClinical medicineCurrent knowledgeHuman diseasesDivergent rolesNumerous studiesCurrent understandingLungInjuryTargetKidneyPathwayDiseaseLiver
2018
Assessment of a multimodal analgesia protocol to allow the implementation of enhanced recovery after cardiac surgery: Retrospective analysis of patient outcomes
Markham T, Wegner R, Hernandez N, Lee J, Choi W, Eltzschig H, Zaki J. Assessment of a multimodal analgesia protocol to allow the implementation of enhanced recovery after cardiac surgery: Retrospective analysis of patient outcomes. Journal Of Clinical Anesthesia 2018, 54: 76-80. PMID: 30412813, DOI: 10.1016/j.jclinane.2018.10.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAirway ExtubationAnalgesiaCardiopulmonary BypassClinical ProtocolsCoronary Artery BypassFemaleHealth Plan ImplementationHumansLength of StayMaleMiddle AgedOperating RoomsPain ManagementPain, PostoperativePatient Outcome AssessmentPerioperative CarePostoperative CareRetrospective StudiesTime FactorsConceptsMultimodal analgesia protocolCardiac surgeryHospital LOSAnalgesia protocolRetrospective analysisEnhanced recoveryPump coronary artery bypass graftControl groupIntensive care unit lengthPost-operative opioid consumptionCoronary artery bypass graftCardiac bypass timeOperating room extubationPost-op complicationsElective cardiac surgeryAortic clamp timeArtery bypass graftSingle-center studyType of surgeryTotal intubation timeCardio-pulmonary bypassICU LOSOpioid consumptionBypass timePerioperative outcomesMicroRNA miR-223 as regulator of innate immunity
Yuan X, Berg N, Lee J, Le T, Neudecker V, Jing N, Eltzschig H. MicroRNA miR-223 as regulator of innate immunity. Journal Of Leukocyte Biology 2018, 104: 515-524. PMID: 29969525, PMCID: PMC6638550, DOI: 10.1002/jlb.3mr0218-079r.Peer-Reviewed Original ResearchConceptsExcessive innate immune responseInnate immune responseInflammatory diseasesMiR-223Immune responseMyeloid cellsAcute respiratory distress syndromeInflammatory bowel diseaseRespiratory distress syndromeMyeloid cell homeostasisMacrophage differentiationMyeloid differentiationMyeloid activationMiR-223 contributesMucosal inflammationBowel diseaseDistress syndromeInflammatory targetsMacrophage functionPotential treatmentInnate immunityTherapeutic enhancementDiseaseNegative feedback mechanismKey modulatorHypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
Koeppen M, Lee J, Seo S, Brodsky K, Kreth S, Yang I, Buttrick P, Eckle T, Eltzschig H. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nature Communications 2018, 9: 816. PMID: 29483579, PMCID: PMC5827027, DOI: 10.1038/s41467-018-03105-2.Peer-Reviewed Original ResearchMeSH KeywordsAmphiregulinAnimalsBasic Helix-Loop-Helix Transcription FactorsCell LineGene Expression RegulationHumansHypoxia-Inducible Factor 1, alpha SubunitIntegrasesMaleMiceMice, TransgenicMicroarray AnalysisMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacMyosinsRNA, Small InterferingSignal TransductionConceptsMyocardial ischemia-reperfusion injuryIschemia-reperfusion injuryHypoxia-inducible factorHIF2 alphaCardiac myocytesIschemic heart diseaseGrowth factor amphiregulinMyocardial ischemia toleranceTranscription factor hypoxia-inducible factorHuman cardiac myocytesAreg deficiencyMyocardial inductionElicit cardioprotectionAREG expressionHeart diseaseHIF1 alphaPharmacologic inhibitionIschemia toleranceAmphiregulinCardioprotectionMyocardial tissueInducible deletionMyocytesInjuryMiceTargeting Hypoxia Signaling for Perioperative Organ Injury
Yuan X, Lee J, Bowser J, Neudecker V, Sridhar S, Eltzschig H. Targeting Hypoxia Signaling for Perioperative Organ Injury. Anesthesia & Analgesia 2018, 126: 308-321. PMID: 28759485, PMCID: PMC5735013, DOI: 10.1213/ane.0000000000002288.Peer-Reviewed Original ResearchConceptsPerioperative organ injuryHypoxia-inducible factorOrgan injurySurgical patientsHIF target genesAcute respiratory distress syndromeRespiratory distress syndromePrevention of ischemiaCurrent therapeutic strategiesNovel pharmacologic strategiesOrgan injury modelsStabilization of HIFPotential clinical approachAcute kidneyGut injuryDistress syndromeReperfusion injuryAnemia treatmentPharmacologic strategiesSurgical outcomesOrgan protectionMyocardial infarctionInjury modelLeading causeTherapeutic strategies
2017
The hypoxia-adenosine link during inflammation
Bowser J, Lee J, Yuan X, Eltzschig H. The hypoxia-adenosine link during inflammation. Journal Of Applied Physiology 2017, 123: 1303-1320. PMID: 28798196, PMCID: PMC5792095, DOI: 10.1152/japplphysiol.00101.2017.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factorInflammatory diseasesAdenosine metabolismAcute lung injuryInflammatory bowel diseaseExtracellular adenosine metabolismFuture treatment approachesLung injuryBowel diseaseMyocardial injuryProinflammatory responseInflammatory conditionsTissue protectionTreatment approachesInflammationTissue conditionsDiseaseHypoxic conditionsDirect targetInjuryHypoxiaTissue integrityMetabolismPatients
2016
Prognostic value and their clinical implication of 89-gene signature in glioma
Shahid M, Cho K, Nguyen M, Choi T, Jo Y, Aryal S, Yoo J, Yun H, Lee J, Eun Y, Lee J, Kang I, Ha J, Yoon H, Kim S, Kim S. Prognostic value and their clinical implication of 89-gene signature in glioma. Oncotarget 2016, 7: 51237-51250. PMID: 27323413, PMCID: PMC5239472, DOI: 10.18632/oncotarget.9983.Peer-Reviewed Original ResearchConceptsPrognostic valueHistological classificationGene signatureIndependent prognostic factorAggressive primary tumorAccurate prognostic valueWorst prognostic groupIndividual therapeutic outcomesAdjuvant chemotherapyOverall survivalPrognostic factorsPrognostic groupsPrimary tumorSubset analysisTumor groupIndividual patientsGlioma prognosisPatientsTherapeutic outcomesClinical implicationsClinical useIDH1 mutationPrognosisMicroarray chipGliomas
Clinical Care
Overview
Clinical Specialties
Anesthesiology