Hyun Jung Kim, MD
About
Research
Publications
2025
Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling
Kim Y, Kim M, Kim S, Lee R, Ujihara Y, Marquez-Wilkins E, Jiang Y, Yang E, Kim H, Lee C, Park C, Kim I. Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling. Nature Communications 2025, 16: 1407. PMID: 39915488, PMCID: PMC11802743, DOI: 10.1038/s41467-025-56720-1.Peer-Reviewed Original ResearchConceptsBlood-brain barrierNeuronal excitabilityB-cateninBarrier functionMouse blood-brain barrierReduced neuronal excitabilityMale mutant miceBlood-brain barrier permeabilityBrain endothelial cellsAutism spectrum disorderNeonatal micePotential therapeutic targetASD risk genesMutant miceTight junctionsImpaired sociabilityPathogenic mechanismsBrain parenchymaEndothelial cellsTherapeutic targetASD pathogenesisSHANK3Adult ageDisabling conditionMice
2024
Mice deficient in TWIK-1 are more susceptible to kainic acid-induced seizures
Kim A, Bae Y, Gadhe C, Jung H, Yang E, Kim H, Lee J, Shim C, Sung Y, Noh J, Kim E, Kang D, Pae A, Hwang E, Park J. Mice deficient in TWIK-1 are more susceptible to kainic acid-induced seizures. IScience 2024, 28: 111587. PMID: 39811670, PMCID: PMC11732521, DOI: 10.1016/j.isci.2024.111587.Peer-Reviewed Original ResearchLithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice
Roh J, Bae M, Kim H, Yang Y, Lee Y, Cho Y, Lee S, Li Y, Yang E, Jang H, Kim H, Kim H, Kang H, Ellegood J, Lerch J, Bae Y, Kim J, Kim E. Lithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice. Molecular Psychiatry 2024, 1-13. PMID: 39633007, DOI: 10.1038/s41380-024-02865-2.Peer-Reviewed Original ResearchAutism spectrum disorderIntellectual disabilityLithium treatmentChronic lithium treatmentASD-related phenotypesCognitive deficitsBehavioral phenotypesSpectrum disorderASD-relatedBrain volumeSynaptic deficitsDYRK1A mutationsNeurodevelopmental disordersDendritic shrinkageHaploinsufficiency of DYRK1ASynaptic proteinsNewborn mutant miceMultiple signaling pathwaysDeficitsDisordersMutant miceDevelopmental delayPatient mutationsK miceSevere microcephalyTranscranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions
Shin H, Nam M, Lee S, Yang S, Yang E, Jung J, Kim H, Woo J, Cho Y, Yoon Y, Cho I. Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions. Nature Communications 2024, 15: 10423. PMID: 39613730, PMCID: PMC11607408, DOI: 10.1038/s41467-024-54759-0.Peer-Reviewed Original ResearchConceptsBrain regionsBrain modulesModulation of brain functionTranscranial brain stimulationMultiple brain regionsUpconversion particlesSymptoms of Parkinson's diseaseOptical crosstalkStudy of neural circuitsFood competition testBrain dysfunctionExternal light sourceLight sourcesBrain functionStudy of complex behaviorsSpatial resolutionNeural circuitsBrain disordersDevelopment of treatmentsOptogenetic techniquesBrain stimulationNeural populationsBrainParkinson's diseaseNeuromodulationCB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum
Choi J, Acharya R, Lim H, Lee K, Seo J, Yang E, Kim H, Yoon J, Chang D, Kim S, Kim S, Birnbaumer L, Suh-Kim H. CB1R activates the epilepsy-associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2409773121. PMID: 39602265, PMCID: PMC11626142, DOI: 10.1073/pnas.2409773121.Peer-Reviewed Original ResearchConceptsDepolarization-induced suppression of excitationCannabinoid receptor type 1Synaptic plasticityDepolarization-induced suppressionSuppression of excitationHeterotrimeric Go proteinAbundant G proteinGi/o-coupled receptorsNeurotransmitter releasePresynaptic terminalsReceptor type 1Regulate neurotransmitter releaseBeam balance testBrain synaptosomal fractionsRegulating neurotransmittersMutated animalsMultiple proteinsKO miceProteomic analysisMotor deficitsCB1RCerebellumEpileptic encephalopathyGo proteinsSignaling pathwayModeling the Determinants of Subjective Well-Being in Schizophrenia
Jeong J, Kim J, Kang N, Ahn Y, Kim Y, Lee D, Kim H. Modeling the Determinants of Subjective Well-Being in Schizophrenia. Schizophrenia Bulletin 2024, sbae156. PMID: 39255414, DOI: 10.1093/schbul/sbae156.Peer-Reviewed Original ResearchObsessive-compulsive symptomsSubjective well-beingDeterminants of subjective well-beingLevels of subjective well-beingStructural equation modelingPsychotic symptomsPrediction of subjective well-beingNeuroleptic Treatment ScaleTreatment of schizophreniaMediation of depressionStructural equation modeling analysisCut-off scoreWell-beingMaintained 6 monthsSchizophrenia treatmentCognitive deficitsSchizophreniaReduce distressTreatment ScaleRelationship patternsArea under the curveSomatizationDepressionEquation modelingIndirect effectsAuthor Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function
Bae M, Roh J, Kim Y, Kim S, Han H, Yang E, Kang H, Lee S, Kim J, Kang R, Jung H, Yoo T, Kim H, Kim D, Oh H, Han S, Kim D, Han J, Bae Y, Kim H, Ahn S, Chan A, Lee D, Kim J, Kim E. Author Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. EMBO Molecular Medicine 2024, 16: 2653-2653. PMID: 39242973, PMCID: PMC11473947, DOI: 10.1038/s44321-024-00125-y.Peer-Reviewed Original ResearchLoss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice
Kang R, Kim K, Jung Y, Choi S, Lee C, Im G, Shin M, Ryu K, Choi S, Yang E, Shin W, Lee S, Lee S, Papadopoulos Z, Ahn J, Koh G, Kipnis J, Kang H, Kim H, Cho W, Park S, Kim S, Kim E. Loss of Katnal2 leads to ependymal ciliary hyperfunction and autism-related phenotypes in mice. PLOS Biology 2024, 22: e3002596. PMID: 38718086, PMCID: PMC11104772, DOI: 10.1371/journal.pbio.3002596.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBehavioral phenotypesASD-relatedSocial communication deficitsAutism-related phenotypesEnlarged lateral ventriclesProgressive ventricular enlargementCommunication deficitsSpectrum disorderSynaptic deficitsEnlargement of brain ventriclesTranscriptomic changesMicrotubule-regulatory proteinsGenes down-regulatedBrain ventriclesVentricular enlargementLateral ventricleDeficitsHippocampal neuronsMotile ciliaKATNAL2Potential treatmentDown-regulationCiliary functionEpendymal cellsComparative Study of the Efficacy and Side Effects of Brand-Name and Generic Clozapine for Long-Term Maintenance Treatment Among Korean Patients With Schizophrenia: A Retrospective Naturalistic Mirror-Image Study
Kang N, Yoon H, Kim H, Jeong J, Kim M, Kwon J. Comparative Study of the Efficacy and Side Effects of Brand-Name and Generic Clozapine for Long-Term Maintenance Treatment Among Korean Patients With Schizophrenia: A Retrospective Naturalistic Mirror-Image Study. Psychiatry Investigation 2024, 21: 311-320. PMID: 38569589, PMCID: PMC10990625, DOI: 10.30773/pi.2023.0413.Peer-Reviewed Original ResearchMirror-image studyMaintenance treatmentTreatment-resistant schizophreniaFormulation of clozapineLong-term maintenance treatmentConcentration-to-dose ratioClozapine useGeneric clozapineClozapineClozarilPsychiatric hospitalNo significant differenceSchizophreniaKorean patientsMedical records of patientsClinical insightsBlood test findingsElectronic medical records of patientsSignificant differenceRecords of patientsBrand-name formulationConcomitant medicationsCo-medicationHospitalization durationLaboratory findings
2023
Key Word Analysis Study on Depression and Anxiety Using Social Big Data During the (COVID)-19 Pandemic in Korea
Lee C, Kim H, Ahn B, Son S. Key Word Analysis Study on Depression and Anxiety Using Social Big Data During the (COVID)-19 Pandemic in Korea. American Journal Of Health Behavior 2023, 47: 68-78. DOI: 10.5993/ajhb.47.6.7.Peer-Reviewed Original Research
News
News
- December 22, 2020
Yale Psychiatrists Present at International Association for Child and Adolescent Psychiatry and Allied Professions Virtual Congress
- September 02, 2020Source: Adolescent Psychiatry
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- August 07, 2020Source: Adolescent Psychiatry
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Yale Medical Group welcomes its newest physicians