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Yale Center for X-Linked Hypophosphatemia

The Yale Center for X-Linked Hypophosphatemia (YC-XLH) is dedicated to improving the health and well-being of patients with disorders of phosphate metabolism, especially X-Linked Hypophosphatemic Rickets.

A National Institute of Arthritis, Musculoskeletal and Skin Disorders-sponsored Center of Research Translation, we support research focused on developing new and more effective treatments for these diseases. We are also committed to partnering with industry to develop and test novel therapies.

Finally, through educational programs, the Center seeks to inform health professionals and the public at large about diagnosing and correctly managing these diseases.

YC-XLH is the lead site of a phase I/II trial of an antibody that neutralizes the action of the novel growth factor, FGF23.
  1. Familial hypophosphatemia and related disorders.
  2. A clinician’s guide to X-linked hypophosphatemia.
  3. An atypical degenerative osteoarthropathy in Hyp mice is characterized by a loss in the mineralized zone of articular cartilage.