Edward Vincent Faustino, MD, MHS
Professor of Pediatrics (Critical Care); Director of Trainee Research, Pediatrics; Chair, Pediatric Protocol Review Committee, Human Investigations Committee; Principal Investigator, Pathobiology, Epidemiology and Interventions against Thrombotic and Hemostatic Outcomes (PEITHO) Program, Pediatrics; Visiting Professor of Pediatrics (University of the Philippines College of Medicine)
Research & Publications
Biography
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Research Summary
Dr. Faustino studies treatment strategies that could improve the outcomes of critically ill children. He is currently focused on the prevention of blood clots in these children. He conducts observational and interventional studies to understand how blood clots form in children.
Specialized Terms: venous thrombosis; thromboembolism; anticoagulation; hemostasis; thrombin generation; platelet; clinical trial; biomarker; risk prediction model; critical care; child
Extensive Research Description
Dr. Faustino is a patient-oriented researcher who focuses on improving the outcomes of critically ill children. His research is focused on the prevention of venous thrombosis and its complications in children. He is the Principal Investigator of the Pathobiology, Epidemiology and Interventions against Thrombotic and Hemostatic Outcomes (PEITHO) Program. The goals of the PEITHO Program are (1) to conduct multi center observational studies that will inform the design and execution of interventional studies on venous thrombosis in children, (2) to conduct multi center randomized clinical trials on the prevention of venous thrombosis in children that will inform clinical practice, and (3) to leverage observational and interventional studies to understand the pathobiology of venous thrombosis in children.
Dr. Faustino is primarily investigating catheter-related thrombosis because the use of central venous catheters is the most common cause of venous thrombosis in children. He has conducted observational studies on the epidemiology of catheter-related thrombosis in critically ill children, completed surveys on thromboprophylaxis in pediatric intensive care units, identified potential biomarkers for catheter-related thrombosis and established collaborations with other researchers invested in the prevention of venous thrombosis. He recently completed a randomized clinical trial on early thromboprophylaxis against catheter-related thrombosis in critically ill children.
Dr. Faustino's ongoing studies include:
1. Age-dependent efficacy of enoxaparin against catheter-related thrombosis in critically ill children. The goal of these studies is to investigate the differential efficacy of enoxaparin between critically ill infants and older children against catheter-related thrombosis.
2. Role of platelets in catheter-related thrombosis in infants. The goal of these studies is to understand the role of platelets in the development of catheter-related thrombosis in infants.
3. Venous thrombosis in children at high risk of bleeding. The goal of these studies is to identify effective strategies against venous thrombosis in surgical or seriously injured children.
4. Venous thrombosis in critically ill adolescents. The goal of these studies is to identify the optimal strategy to prevent venous thrombosis in critically ill adolescents.
Coauthors
Research Interests
Anticoagulants; Antithrombin III; Blood Coagulation; Blood Platelets; Child; Critical Care; Hemostasis; Pediatrics; Pulmonary Embolism; Thrombin; Thromboembolism; Biomarkers; Clinical Trial; Venous Thrombosis
Selected Publications
- Hospital-Acquired Venous Thromboembolism and Invasive Mechanical Ventilation: A Report From the Children’s Hospital Acquired Thrombosis ConsortiumSochet A, Jaffray J, Branchford B, Havlicek E, Mosha M, Amankwah E, Ignjatovic V, Faustino E, Goldenberg N. Hospital-Acquired Venous Thromboembolism and Invasive Mechanical Ventilation: A Report From the Children’s Hospital Acquired Thrombosis Consortium. Pediatric Critical Care Medicine 2023, 25: e82-e90. PMID: 37882641, PMCID: PMC10843146, DOI: 10.1097/pcc.0000000000003383.
- Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort studyHavlicek E, Goldman Z, Faustino E, Ignjatovic V, Goldenberg N, Sochet A. Hospital-acquired venous thromboembolism during invasive mechanical ventilation in children: a single-center, retrospective cohort study. Journal Of Thrombosis And Haemostasis 2023, 21: 3145-3152. PMID: 37423387, DOI: 10.1016/j.jtha.2023.06.035.
- Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*Sanchez-Pinto L, Bennett T, Stroup E, Luo Y, Atreya M, Bubeck Wardenburg J, Chong G, Geva A, Faustino E, Farris R, Hall M, Rogerson C, Shah S, Weiss S, Khemani R. Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock*. Pediatric Critical Care Medicine 2023, 24: 795-806. PMID: 37272946, PMCID: PMC10540758, DOI: 10.1097/pcc.0000000000003292.
- Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled TrialsZinter M, Markovic D, Asaro L, Nadkarni V, McQuillen P, Sinha P, Matthay M, Jeschke M, Agus M, Sapru A, Agus M, Coughlin-Wells K, Hughes K, French J, Fitzgerald M, Srinivasan V, Sisko M, Chima R, Howard K, Jones R, Thomas N, Spear D, Li S, Pinto A, Eldridge P, Newth C, Kwok J, Hassinger A, Qiao H, Bysani K, Monjure T, Faustino E, Tala J, Kandil S, Quinn T, Hirshberg E, Lilley J, Wintergerst K, Sullivan J, Lee K, Schwarz A, Flores C, Vargas-Shiraishi O, Sorce L, Marsillio L, Shukla A, Cvijanovich N, Flori H, Brumfield B, Stone C, Dahmer M, Jayachandran C, Federman M, Wong K, Vangala S, Pellegrini M, Balliu B, Gala K, Kirkpatrick T, Deshmukh T, Mareboina M, Do N, Ashtari N, Ratiu A, Nett S, Singleton M, Jarvis D, McNally M, Martini K, Pinto N, Chong G, Rodgers C, Viteri S, John R, Mulholland T, Pellicciotti G, Sapru A, McQuillen P, Zinter M, Goel S, Alkhouli M, McKenzie A, Villarreal-Chico D. Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 945-949. PMID: 36656551, PMCID: PMC10111993, DOI: 10.1164/rccm.202210-1988le.
- Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children.Sochet A, Havlicek E, Faustino E, Goldenberg N. Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children. Hospital Pediatrics 2022, 12: 1099-1109. PMID: 36349533, DOI: 10.1542/hpeds.2022-006697.
- Practical considerations and consensus opinion for children’s hospital–based inpatient hemostasis and thrombosis (HAT) consultative services: Communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and HemostasisWoods GM, Raffini L, Brandão LR, Jaffray J, Branchford BR, Ng CJ, Sartain SE, Pak J, Male C, Zia A, Rizzi M, Sirachainan N, Faustino E, Carpenter SL, Goldenberg NA. Practical considerations and consensus opinion for children’s hospital–based inpatient hemostasis and thrombosis (HAT) consultative services: Communication from the ISTH SSC Subcommittee on Pediatric/Neonatal Thrombosis and Hemostasis. Journal Of Thrombosis And Haemostasis 2022, 20: 2151-2158. PMID: 35748322, DOI: 10.1111/jth.15798.
- Introduction of Hydroxyurea Therapy to a Cohort of Sickle Cell Patients in Northern HaitiPaul-Hanna M, Joseph W, Mondesir W, Faustino EVS, Canarie MF. Introduction of Hydroxyurea Therapy to a Cohort of Sickle Cell Patients in Northern Haiti. Journal Of Pediatric Hematology/Oncology 2022, 44: 351-353. PMID: 35180761, DOI: 10.1097/mph.0000000000002431.
- Pharmacologic restraint during ED mental health visitsFaustino E. Pharmacologic restraint during ED mental health visits. The Journal Of Pediatrics 2021, 236: 1-3. DOI: 10.1016/j.jpeds.2021.07.028.
- Design and Development of A-vent: A Low-Cost Ventilator with Cost-Effective Mobile Cloud Caching and Embedded Machine LearningCabacungan P, Oppus C, Cabacungan N, Mamaradlo J, Santiago P, Mercado N, Faustino E, Tangonan G. Design and Development of A-vent: A Low-Cost Ventilator with Cost-Effective Mobile Cloud Caching and Embedded Machine Learning. 2021, 00: 1-8. DOI: 10.1109/tensymp52854.2021.9550920.
- Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT)Hirshberg E, Alexander J, Asaro L, Coughlin-Wells K, Steil G, Spear D, Stone C, Nadkarni V, Agus M, Investigators H, Agus M, Wypij D, Asaro L, Nadkarni V, Srinivasan V, Biagas K, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Luckett P, Fackler J, Rozen T. Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial Heart and Lung Failure-Pediatric Insulin Titration Trial (HALF-PINT). CHEST Journal 2021, 160: 919-928. PMID: 33932465, PMCID: PMC8449010, DOI: 10.1016/j.chest.2021.04.049.
- Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care.Natale J, Asaro L, Joseph J, Ulysse C, Ascenzi J, Bowens C, Wypij D, Curley M, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Vander Heyden M, Watson R, Wells C. Association of Race and Ethnicity with Sedation Management in Pediatric Intensive Care. Annals Of The American Thoracic Society 2021, 18: 93-102. PMID: 32776853, PMCID: PMC7780975, DOI: 10.1513/annalsats.201912-872oc.
- 623: Risk Assessment Scoring for Venous Thromboembolism in Critically Ill AdolescentsGupta A, Faustino E. 623: Risk Assessment Scoring for Venous Thromboembolism in Critically Ill Adolescents. Critical Care Medicine 2020, 49: 305-305. DOI: 10.1097/01.ccm.0000728380.57915.da.
- Intravenous magnesium for asthma exacerbationFaustino E. Intravenous magnesium for asthma exacerbation. The Journal Of Pediatrics 2020, 220: 1-3. DOI: 10.1016/j.jpeds.2020.03.045.
- Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory FailureDahmer M, Flori H, Sapru A, Kohne J, Weeks H, Curley M, Matthay M, Quasney M, Network B, Bateman S, Berg M, Borasino S, Bysani G, Cowl A, Bowens C, Faustino E, Fineman L, Godshall A, Hirshberg E, Kirby A, McLaughlin G, Medar S, Oren P, Schneider J, Schwarz A, Shanley T, Sorce L, Truemper E, Heyden M, Wittmayer K, Zuppa A, Wypij D. Surfactant Protein D Is Associated With Severe Pediatric ARDS, Prolonged Ventilation, and Death in Children With Acute Respiratory Failure. CHEST Journal 2020, 158: 1027-1035. PMID: 32275979, PMCID: PMC7478231, DOI: 10.1016/j.chest.2020.03.041.
- Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic ControlBiagas K, Hinton V, Hasbani N, Luckett P, Wypij D, Nadkarni V, Agus M, investigators H, Srinivasan V, Mourani P, Chima R, Thomas N, Li S, Pinto A, Newth C, Hassinger A, Bysani K, Rehder K, Faustino E, Kandil S, Hirshberg E, Wintergerst K, Schwarz A, Bagdure D, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Pinto N, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin J, Jouvet P, Yanay O, Allen C, Asaro L, Coughlin-Wells K, French J, Natarajan A, Network T. Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. The Journal Of Pediatrics 2020, 218: 57-63.e5. PMID: 31910992, PMCID: PMC7122648, DOI: 10.1016/j.jpeds.2019.10.055.
- 50 Years Ago in T he J ournal of P ediatrics Thromboses Due to Catheterization in Infants and ChildrenKandil S, Faustino EV. 50 Years Ago in T he J ournal of P ediatrics Thromboses Due to Catheterization in Infants and Children. The Journal Of Pediatrics 2020, 216: 100. PMID: 31843106, DOI: 10.1016/j.jpeds.2019.07.067.
- 308: SHORT-TERM ADVERSE OUTCOMES ASSOCIATED WITH HYPOGLYCEMIA IN CRITICALLY ILL CHILDRENFaustino E, Hirshberg E, Biagas K, Asaro L, Pinto N, Srinivasan V, Bagdure D, Wypij D, Steil G, Coughlin-Wells K, Nadkarni V, Agus M. 308: SHORT-TERM ADVERSE OUTCOMES ASSOCIATED WITH HYPOGLYCEMIA IN CRITICALLY ILL CHILDREN. Critical Care Medicine 2019, 47: 135-135. DOI: 10.1097/01.ccm.0000551062.09983.f9.
- Sedation Management for Critically Ill Children with Pre-Existing Cognitive ImpairmentBest K, Asaro L, Curley M, Investigators R, Wypij D, Allen G, Angus D, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Heyden M, Watson R, Wells C. Sedation Management for Critically Ill Children with Pre-Existing Cognitive Impairment. The Journal Of Pediatrics 2018, 206: 204-211.e1. PMID: 30527750, PMCID: PMC6389364, DOI: 10.1016/j.jpeds.2018.10.042.
- 413Srinivasan V, Hasbani N, Asaro L, Mehta N, Irving S, Kandil S, Allen C, Typpo K, Cvijanovich N, Faustino E, Wypij D, Agus M, Nadkarni V. 413. Critical Care Medicine 2018, 46: 190. DOI: 10.1097/01.ccm.0000528431.32594.04.
- Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical TrialNatale J, Lebet R, Joseph J, Ulysse C, Ascenzi J, Wypij D, Curley M, Investigators R, Curley M, Wypij D, Allen G, Angus D, Asaro L, Ascenzi J, Bateman S, Borasino S, Bowens C, Bysani G, Cheifetz I, Cowl A, Dodson B, Faustino E, Fineman L, Flori H, Franck L, Gedeit R, Grant M, Harabin A, Haskins-Kiefer C, Hertzog J, Hutchins L, Kirby A, Lebet R, Matthay M, McLaughlin G, Natale J, Oren P, Polavarapu N, Schneider J, Schwarz A, Shanley T, Simone S, Singer L, Sorce L, Truemper E, Heyden M, Watson R, Wells C. Racial and Ethnic Disparities in Parental Refusal of Consent in a Large, Multisite Pediatric Critical Care Clinical Trial. The Journal Of Pediatrics 2017, 184: 204-208.e1. PMID: 28410087, DOI: 10.1016/j.jpeds.2017.02.006.
- Tight Glycemic Control in Critically Ill ChildrenAgus M, Wypij D, Hirshberg E, Srinivasan V, Faustino E, Luckett P, Alexander J, Asaro L, Curley M, Steil G, Nadkarni V. Tight Glycemic Control in Critically Ill Children. New England Journal Of Medicine 2017, 376: 729-741. PMID: 28118549, PMCID: PMC5444653, DOI: 10.1056/nejmoa1612348.
- 511Faustino E, Shabanova V. 511. Critical Care Medicine 2016, 44: 204. DOI: 10.1097/01.ccm.0000509189.52681.88.
- 522White L, Fredericks R, Mannarino C, Janofsky S, Faustino E. 522. Critical Care Medicine 2016, 44: 207. DOI: 10.1097/01.ccm.0000509200.98423.76.
- 602Faustino E, Li S, Pinto M, Trakas E, Gertz S, Miksa M, Silva C. 602. Critical Care Medicine 2016, 44: 227. DOI: 10.1097/01.ccm.0000509279.64732.0c.
- Thromboprophylaxis in critically ill children in Spain and PortugalNúñez A, Fonte M, Faustino E, del estudio multicéntrico internacional PROTRACT E. Thromboprophylaxis in critically ill children in Spain and Portugal. Anales De Pediatría (English Edition) 2015, 82: 144-151. DOI: 10.1016/j.anpede.2014.05.002.
- Assessing the benefits and risks of tight glycemic control in critically ill childrenFaustino E, Kandil S. Assessing the benefits and risks of tight glycemic control in critically ill children. Pediatric Health Medicine And Therapeutics 2014, Volume 5: 93-98. DOI: 10.2147/phmt.s50410.
- Hyperglycemia, Dysglycemia and Glycemic Control in Pediatric Critical CareAgus M, Faustino E, Rigby M. Hyperglycemia, Dysglycemia and Glycemic Control in Pediatric Critical Care. 2014, 93-101. DOI: 10.1007/978-1-4471-6416-6_8.
- ABSTRACT 114Faustino E, Li S, Pinto M, Polikoff L, Tala J, Silva C, Shapiro E. ABSTRACT 114. Pediatric Critical Care Medicine 2014, 15: 31. DOI: 10.1097/01.pcc.0000448840.20300.dd.
- ReplyFaustino E, Apkon M. Reply. The Journal Of Pediatrics 2006, 148: 847-848. DOI: 10.1016/j.jpeds.2006.01.015.
Clinical Trials
| Conditions | Study Title |
|---|---|
| Diseases of the Cardiovascular System | Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies (CRETE) |
| Children's Health; Genetics - Pediatric | Pediatric Genomics Discovery Program (PGDP) |
| COVID-19 Inpatient; COVID-19 Outpatient | The RECOVER Long Covid Study at Yale |