Nadia Ameen, MBBS
Cards
About
Titles
Professor of Pediatrics (Gastroenterology)
Affiliated Faculty, Yale Institute for Global HealthBiography
I am a URM physician-scientist and Professor of Pediatrics (Gastroenterology), Cellular and Molecular Physiology at the Yale University School of Medicine. I have led an NIH-supported laboratory for over 2 decades and trained multiple undergraduate students, post-docs, medical students and research scientists, the majority of whom come from under-represented backgrounds. My research interest is focused on mechanisms responsible for diarrheal diseases. My lab primarily investigates mechanisms regulating the CFTR chloride channel in the intestine and how these are linked to genetic, and non-genetic diarrheal diseases and Cystic Fibrosis (CF). We elucidated trafficking mechanisms regulating CFTR that are implicated in diarrhea that are the basis for successful drug therapies to treat constipation and increase intestinal fluidity (Linaclotide, Lubiprostone). Currently, we investigate kinase signaling mechanisms responsible for regulating CFTR in genetic and non genetic diarrheal diseases and CF affecting newborns and children.
My clinical practice is focused on food and gut health in children to treat and prevent obesity, and chronic lifestyle diseases. We promote the use of healthy food for prevention of intestinal diseases in children, provide nutritional consultation, and design culturally sensitive diets for parents. We provide conventional standard of care along side nutritional promotion as needed, but focus on foods, exercise, stress reduction and lifestyle as a primary modalities for disease treatment and prevention.
Appointments
Pediatric Gastroenterology & Hepatology
ProfessorPrimaryCellular & Molecular Physiology
ProfessorSecondary
Other Departments & Organizations
- Ameen Lab
- Cellular & Molecular Physiology
- Discovery to Cure Internship
- Molecular Medicine, Pharmacology, and Physiology
- Pediatric Colorectal Disorders Program
- Pediatric Gastroenterology & Hepatology
- Pediatric Healthy Gut & Constipation Program
- Pediatrics
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Institute for Global Health
- Yale Ventures
Education & Training
- MBBS
- University of West Indies (1985)
Research
Academic Achievements and Community Involvement
Links & Media
Media
Immunolocalization of NHE3 in Human MVID small intestine
We were first to show how apical ion transporters are dysregulated in MVID to account for diarrhea in this diseaseHuman Intestinal Organoids in culture
We use human intestinal biopsies to culture organoids, that are used to investigate CFTR and other epithelial transporters
News
- June 10, 2024
Yale Child Study Center welcomes 2024 summer interns
- July 16, 2020Source: American Journal of Physiology-Gastrointestinal and Liver Physiology
Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea