Brian Feldman, MD, PhD
Professor of Pediatrics (Endocrinology)Cards
About
Research
Publications
2024
White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models
Li L, Feldman B. White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models. Journal Of Clinical Investigation 2024, 134: e172360. PMID: 38949025, PMCID: PMC11213504, DOI: 10.1172/jci172360.Peer-Reviewed Original ResearchConceptsWhite adipose tissueSubcutaneous white adipose tissueBrown adipose tissueDeletion of KLF15Transcription factor KLF15Visceral white adipose tissueHuman adipose cellsWhite adipocytesAdipose tissueMolecular mechanismsKLF15Adipose cellsDepot-specificAdipocytesNormal physiologySubcutaneous fat depotsCell-specific propertiesAdipose tissue depotsHealthy adipose tissueDirectional regulationMetabolic diseasesDevelopment of therapiesPathwayCellsMouse model
2023
Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo
Babel N, Feldman B. Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo. Steroids 2023, 201: 109336. PMID: 37944652, PMCID: PMC11005958, DOI: 10.1016/j.steroids.2023.109336.Peer-Reviewed Original ResearchQuantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown
Li L, Gunewardena A, Nyima T, Feldman B. Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown. STAR Protocols 2023, 4: 102607. PMID: 37742183, PMCID: PMC10751552, DOI: 10.1016/j.xpro.2023.102607.Peer-Reviewed Original ResearchIdentification of an adipose tissue-resident pro-preadipocyte population
Chen M, Kim S, Li L, Chattopadhyay S, Rando T, Feldman B. Identification of an adipose tissue-resident pro-preadipocyte population. Cell Reports 2023, 42: 112440. PMID: 37119138, PMCID: PMC10370484, DOI: 10.1016/j.celrep.2023.112440.Peer-Reviewed Original ResearchConceptsDeconvolution of cell typesSingle-cell RNA sequencingCell typesScRNA-seqRNA sequencingRegulate adipogenesisPopulation of cellsHeterogeneous population of cellsExpression profilesStromal vascular fractionAdipocyte lineagePreadipocyte populationPathwayProgenitor cellsTherapeutic opportunitiesCellsPhysiological mechanismsAdipose tissueHeterogeneous populationLineagesStem cellsFunctional propertiesPreadipocytesProgenitorsSequence
2021
MYH9 facilitates autoregulation of adipose tissue depot development
Cheung S, Sayeed M, Nakuluri K, Li L, Feldman B. MYH9 facilitates autoregulation of adipose tissue depot development. JCI Insight 2021, 6: e136233. PMID: 33986190, PMCID: PMC8262332, DOI: 10.1172/jci.insight.136233.Peer-Reviewed Original ResearchConceptsMature adipocytesProgenitor cellsModulate systemic metabolismAdipogenesis in vivoPostnatal lifeExtracellular inputsWhite adipose tissueHormone signalingAdipose tissueEarly postnatal lifeDifferentiation of progenitor cellsTissue formation in vivoFormation in vivoEnergy storageSystemic metabolismAdipose depotsAdipocytesMYH9CellsDepot formationTissueAdipose14 The Adrenal Cortex and Its Disorders
Miller W, Flück C, Breault D, Feldman B. 14 The Adrenal Cortex and Its Disorders. 2021, 425-490. DOI: 10.1016/b978-0-323-62520-3.00014-2.Peer-Reviewed Original ResearchAdrenocorticotropic hormoneSteroid measurementsDeficiency statesLong-term glucocorticoid treatmentGenetic disordersEvaluation of adrenal functionHormone productionAssociated with genetic disordersSteroid hormone productionSteroidogenic cellsPrincipal mineralocorticoidAdrenal tumorsAdrenal insufficiencyCushing's syndromeAdrenal disordersSteroid excessConn's syndromeTumor originGlucocorticoid treatmentMineralocorticoid excessAdrenal functionGlucocorticoid excessAddison's diseaseGenetic causeAdrenal cortex
2020
SAT-585 Autoregulation of Adipose Tissue Development
Feldman B, Sayeed M, Nakuluri K. SAT-585 Autoregulation of Adipose Tissue Development. Journal Of The Endocrine Society 2020, 4: sat-585. PMCID: PMC7209260, DOI: 10.1210/jendso/bvaa046.389.Peer-Reviewed Original ResearchWhite adipose tissueABSTRACT White adipose tissueMature adipocytesProgenitor cellsModulate systemic metabolismPostnatal lifeAdipose depotsAdipogenesis in vivoTissue formation in vivoExtracellular inputsAdipose tissueHormone signalingEnergy storageEarly postnatal lifeDifferentiation of progenitor cellsUnrecognized signalFormation in vivoSystemic metabolismAdipocytesHomeostatic levelsAdipogenesisCellsAdiposeDepot formationA Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography
Huang Y, Zhao N, Wang Y, Truillet C, Wei J, Blecha J, VanBrocklin H, Seo Y, Sayeed M, Feldman B, Aggarwal R, Behr S, Shao H, Wilson D, Villanueva-Meyer J, Gestwicki J, Evans M. A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS Chemical Biology 2020, 15: 1381-1391. PMID: 32255605, PMCID: PMC8031368, DOI: 10.1021/acschembio.9b01043.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBind GRGlucocorticoid receptorEmission tomographyGR agonist dexamethasoneGlucocorticoid receptor expressionGR modulatorsAdipose tissue of miceGR expression levelsTissues of miceReceptor expressionAgonist dexamethasoneArylboronic acid pinacol estersGR expressionKnockout miceGR signalingNuclear hormone receptorsPharmacological modulationHormone receptorsSevere diseaseAdipose tissueTissue levelsDecay corrected radiochemical yieldMiceHistorical screening
2019
A novel platform for isotype-specific testing of autoantibodies
Carter K, Treurnicht A, Davis K, Kumar R, Feldman B. A novel platform for isotype-specific testing of autoantibodies. PLOS ONE 2019, 14: e0211596. PMID: 30730939, PMCID: PMC6366878, DOI: 10.1371/journal.pone.0211596.Peer-Reviewed Original Research
2018
A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis
Jung Y, Feldman B. A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis. Adipocyte 2018, 7: 273-276. PMID: 30153756, PMCID: PMC6768266, DOI: 10.1080/21623945.2018.1516099.Peer-Reviewed Original ResearchConceptsAdipocyte precursor cellsCircadian clockKruppel-like factor 15Tissue-specific signalsAdipose tissue biologyFeeding/fasting cyclesRobust clockPeripheral circadian clocksDay/night cycleCentral circadian clockMolecular networksCentral pacemakerTissue biologyAdipocytesMetabolismAdipogenesisPathwayOutput pathwaysPrecursor cellsPER3Therapeutic strategiesAdipose tissueCellsFeeding/fasting