Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsCynthia Mann, MD
Associate Clinical ProfessorAbout
Research
Publications
2026
Targeting of the nuclear RNA exosome to chromatin by HP1 affects the transcriptional programs of liver cells
Souaifan H, Costallat M, Sitkiewicz L, Godest K, Cammas F, Mann C, Muchardt C, Rachez C. Targeting of the nuclear RNA exosome to chromatin by HP1 affects the transcriptional programs of liver cells. Nature Communications 2026 PMID: 42056110, DOI: 10.1038/s41467-026-72504-7.Peer-Reviewed Original ResearchHeterochromatin protein 1Extracellular matrix componentsRNA degradationTranscriptional programsNuclear RNA exosome complexHeterochromatin protein 1 isoformsHeterochromatin protein 1 expressionRNA decay machineryRNA exosome complexCo-transcriptional processesRetrotransposon-derived RNAsExosome complexRNA turnoverDecay machineryPericentromeric heterochromatinEnhancer RNAsMatrix componentsExosome activityRegulated genesCollagen genesRNAHepatocellular carcinoma samplesGenesLiver cellsCancer biology