Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsThomas D'Hooghe, MD, PhD
Professor (Adjunct) of Obstetrics, Gynecology, and Reproductive SciencesAbout
Research
Publications
2025
Consistency in treatment effects and statistical significance between early-stage pregnancy endpoints and live birth in randomized controlled trials of infertility: a systematic meta-epidemiological study
Feng Q, Li W, Crispin J, Longobardi S, D'Hooghe T, Li W, Mol B. Consistency in treatment effects and statistical significance between early-stage pregnancy endpoints and live birth in randomized controlled trials of infertility: a systematic meta-epidemiological study. Fertility And Sterility 2025 PMID: 40876726, DOI: 10.1016/j.fertnstert.2025.08.025.Peer-Reviewed Original ResearchPregnancy EndpointsRandomized Controlled TrialsLive birthsClinical pregnancyLive birth dataStatistical significanceInfertility treatmentBirth dataMedically assisted reproduction treatmentsTreatment effectsMeta-epidemiological studyCorrelation of treatment effectsBiochemical pregnancySpearman's rhoChi-square testOvarian stimulationSubfertile womenPregnancy lossPregnancy dataPregnancyReproduction treatmentControlled TrialsGold standardInfertilityEndpointWeighing Parenthood Wishes: A Conjoint Analysis of Criteria to Prioritize Infertile Couples for Publicly Funded Fertility Treatment
Van Muylder A, Kessels R, D’Hooghe T, Luyten J. Weighing Parenthood Wishes: A Conjoint Analysis of Criteria to Prioritize Infertile Couples for Publicly Funded Fertility Treatment. Medical Decision Making 2025, 45: 1034-1051. PMID: 40826820, DOI: 10.1177/0272989x251353524.Peer-Reviewed Original ResearchBiological childrenIn vitro fertilizationInfertility causeCost of IVF treatmentPublic fundsSame-sex relationshipsPartner ageCivil statusFertilizer treatmentsLife goalsFunding prioritiesPublic supportBelgian populationBelgian policyHard choicesIVF treatmentInfertile couplesPolicy makersFunding policiesPolicyLogit modelInfertilitySociodemographic groupsDiscrete-choice experimentFundingA commentary on “Online fertility workup with video consultation for infertility patients; a randomized controlled trial”
Zheng W, Schwarze J, D'Hooghe T. A commentary on “Online fertility workup with video consultation for infertility patients; a randomized controlled trial”. Fertility And Sterility 2025, 124: 456-457. PMID: 40614894, DOI: 10.1016/j.fertnstert.2025.06.042.Peer-Reviewed Original ResearchConsidering minimal clinically important differences in assisted reproductive technology
Schwarze J, Broekmans F, Gupta S, Tennant P, Sunkara S, D'Hooghe T. Considering minimal clinically important differences in assisted reproductive technology. Fertility And Sterility 2025, 124: 1051-1060. PMID: 40578658, DOI: 10.1016/j.fertnstert.2025.06.026.Peer-Reviewed Original ResearchMinimal Clinically Important DifferenceClinically Important DifferenceAssisted Reproductive TechnologyLive birthsMinimal clinically important difference thresholdAssisted reproductive technology proceduresImportant differenceReproductive technologyCumulative live birthEvidence of superiorityClinical pregnancyGroup of womenDiverse prognosisClinical significancePregnancy rateStatistical significancePregnancyBirthPublished literatureTreatmentRecommendation to improve the rigor and impact of nonrandomized studies of interventions in fertility treatment research
Schwarze J, Tennant P, Barnhart K, Platt R, Gupta S, Venetis C, D'Hooghe T, Schisterman E. Recommendation to improve the rigor and impact of nonrandomized studies of interventions in fertility treatment research. Fertility And Sterility 2025, 124: 749-758. PMID: 40467028, DOI: 10.1016/j.fertnstert.2025.05.168.Peer-Reviewed Original ResearchAssisted Reproductive TechnologyNonrandomized studies of interventionsRandomized Controlled TrialsNonrandomized studiesStudies of interventionsClinical practiceOvarian stimulationNon-randomized Studies of InterventionsMultidisciplinary expert consensusSelection biasAssisted reproductive technology researchReproductive technologyMethodological rigorStudy designEvidence-based clinical practiceEmbryo transferIntervention study designPatient populationTreatment outcomesDiverse patient populationsClinical decision makingGold standardControlled TrialsStudy protocolExpert consensusP-360 Should unregistered trials be excluded from systematic reviews? Exploring the association between trial registration and reporting inflated effect sizes among randomized controlled trials of infertility
Mol B, Feng Q, Li W, Crispin J, Longobardi S, D’Hooghe T, Li W. P-360 Should unregistered trials be excluded from systematic reviews? Exploring the association between trial registration and reporting inflated effect sizes among randomized controlled trials of infertility. Human Reproduction 2025, 40: deaf097.666. DOI: 10.1093/humrep/deaf097.666.Peer-Reviewed Original ResearchRandomized Controlled TrialsTrial registration statusSystematic reviewEffect sizeTRIAL REGISTRATIONSecondary analysisLive birthsSecondary analyses of randomized controlled trialsUnregistered trialsSystematic searchAssessment of randomized controlled trialsVolume of trialsTrial publicationsPoisson regression modelsSystematic searches of EMBASERegistration statusStudy questionsSearch of EmbaseAnalysis of randomized controlled trialsBlanket exclusionEuropean UnionBirth outcomesAdjusted multivariate analysisLive birth outcomesAbstract Study questionP-625 A machine learning model outperformed fertility specialists in predicting the number of oocytes retrieved based on patient profile and predefined r-hFSH-α starting dose
Hourvitz R, Ettie M, Polyzos N, Zheng W, Lippolis E, D’Hooghe T, Baum M, Luz A, Reuvenny S, Yitzhak N, Hourvitz A. P-625 A machine learning model outperformed fertility specialists in predicting the number of oocytes retrieved based on patient profile and predefined r-hFSH-α starting dose. Human Reproduction 2025, 40: deaf097.931. DOI: 10.1093/humrep/deaf097.931.Peer-Reviewed Original ResearchA video clip detailing the patient journey on the day of oocyte retrieval in addition to the standard of care: a randomized controlled trial
Dias L, De Loecker P, Willems S, D’Hooghe T, Vriens J, Peeraer K, Dancet E. A video clip detailing the patient journey on the day of oocyte retrieval in addition to the standard of care: a randomized controlled trial. Human Reproduction 2025, 40: 664-674. PMID: 40056004, DOI: 10.1093/humrep/deaf033.Peer-Reviewed Original ResearchConceptsDay of oocyte retrievalQualitative process evaluationOocyte retrievalState-Trait Anxiety InventoryMen’s anxietyRandomized Controlled TrialsAffiliate of Merck KGaAMonth recruitment periodInfertility-specific distressIntervention groupPatient journeyWomen's anxietyHeterosexual couplesFertility centreIVF cyclesAttention control groupHealth information overloadEducational intervention studyRandomized controlled designElectronic medical recordsStandard of careDutch-speaking populationIVFControl groupIntention-to-treat analysisThe presence, clarity, and consistency of definitions in pregnancy outcomes in infertility trials: a systematic review
Feng Q, Li W, Li W, Wang R, Crispin J, Longobardi S, D’Hooghe T, Mol B. The presence, clarity, and consistency of definitions in pregnancy outcomes in infertility trials: a systematic review. Human Reproduction 2025, 40: 654-663. PMID: 39983754, PMCID: PMC11965792, DOI: 10.1093/humrep/deaf022.Peer-Reviewed Original ResearchConceptsRandomized Controlled TrialsClinical pregnancyBiochemical pregnancyPregnancy outcomesLive birthsNHMRC Investigator grantInfertility trialsGestational age thresholdOutcome definitionsStudy funding/competing interest(sInvestigator GrantReport live birthCut-offGestational ageGestational weeksOngoing pregnancySingle-centerFUNDING/COMPETING INTEREST(SWider implicationsInfertile womenPregnancyChina Scholarship CouncilProportion of trialsInterim analysisManual data extractionInternational multistakeholder consensus statement on post‐publication integrity issues in randomized clinical trials by Cairo Consensus Group
Khan K, Fawzy M, Chien P, Geary M, Bueno‐Cavanillas A, Nunez‐Nunez M, Zamora J, Bedaiwy M, Serour G, D'Hooghe T, Pacey A, Andrews J, Scott J, Ball E, Mahran A, Aboulghar M, Wasim T, Abdelaleem M, Maheshwari A, Odibo A, Sallam H, Grandi G, Zhang J, Fernández‐Luna J, Jawid S, Mignini L, Khalaf Y. International multistakeholder consensus statement on post‐publication integrity issues in randomized clinical trials by Cairo Consensus Group. International Journal Of Gynecology & Obstetrics 2025, 169: 1093-1115. PMID: 39887735, DOI: 10.1002/ijgo.16118.Peer-Reviewed Original Research