Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsKristopher Kahle, MD, PhD
Assistant Professor AdjunctAbout
Research
Publications
2025
Transient Receptor Potential channels (TRP) in GtoPdb v.2025.4
Blair N, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Liu Q, Liu B, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clercq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2025.4. IUPHAR/BPS Guide To Pharmacology CITE 2025, 2025 DOI: 10.2218/gtopdb/f78/2025.4.Peer-Reviewed Original ResearchTRPC channelsTransient receptor potential channelsDetection of noxious heatCongenital stationary night blindnessCalcium-activated cationStore-operated channelsPlacental trophoblast cellsNMDA receptorsAdenosine diphosphate riboseSlow afterdepolarizationNoxious heatC-terminal kinase regionSplice variantsIntracellular ATP levelsCation channelsChannel activityNeurodegenerative disorder mucolipidosis type IVTRPA1 activationDepletion of intracellular calcium storesMucolipidosis type IVTRP channelsAssociated with conduction defectsDevelopment of heat hyperalgesiaDevelopment of thermal hyperalgesiaDynamic intracellular vesicular structuresEffect of GLP‐1 receptor agonists on idiopathic intracranial hypertension: A systematic review
de Oliveira H, Ruelas M, Fonseca P, Diaz C, de Paula G, da Costa P, Parker T, Kahle K. Effect of GLP‐1 receptor agonists on idiopathic intracranial hypertension: A systematic review. Headache The Journal Of Head And Face Pain 2025 PMID: 41246926, DOI: 10.1111/head.70005.Peer-Reviewed Original ResearchIdiopathic intracranial hypertensionGLP-1 RAsInternational Prospective RegisterCochrane Central RegisterGLP-1Receptor agonistsGLP-1RAIntracranial hypertensionWorld Health Organization-International Clinical Trials Registry PlatformHeadache burdenEffects of GLP-1 receptor agonistsClinical effectsEffects of glucagon-like peptide-1 receptor agonistsGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsGLP-1 receptor agonistsInternational Prospective Register of Systematic ReviewsSystematic reviewProspective Register of Systematic ReviewsMild gastrointestinal symptomsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsGLP-1RA treatmentRegister of Controlled TrialsElevated intracranial pressureConcurrent Chiari malformation type I and hydrocephalus: Integrating mechanistic and pathophysiological insights toward a unified management paradigm
Davalan W, Mehta N, Jackson E, Rocque B, Duy P, Muñoz W, Kundishora A, Mekbib K, Limbrick D, Kahle K. Concurrent Chiari malformation type I and hydrocephalus: Integrating mechanistic and pathophysiological insights toward a unified management paradigm. Experimental Neurology 2025, 396: 115535. PMID: 41173227, DOI: 10.1016/j.expneurol.2025.115535.Peer-Reviewed Original ResearchConceptsChiari malformation type IPosterior fossa decompressionCM-ICerebrospinal fluidPosterior fossa hypoplasiaCSF diversionCraniospinal pressure dissociationPremature suture fusionVenous outflow restrictionType ITonsillar descentCerebrospinal fluid dynamicsHindbrain herniationSurgical outcomesSyndromic craniosynostosesSecondary hydrocephalusSyndrome casesClinical managementDevelopmental anomaliesDiagnostic accuracyPathophysiological mechanismsAnatomical classificationTreatment selectionHydrocephalusPathophysiological insightsSomatic TEK Mutation Identified in a Patient with Calvarial Venous Malformations
Fan B, Dennis E, Mehta N, Davalan W, Fortes C, Swamy A, Muñoz W, Jaimes C, Hale A, Kahle K. Somatic TEK Mutation Identified in a Patient with Calvarial Venous Malformations. Genes 2025, 16: 1123. PMID: 41153341, PMCID: PMC12564052, DOI: 10.3390/genes16101123.Peer-Reviewed Original ResearchConceptsVenous malformationsScRNA-seqScRNA-seq data analysisSingle-cell RNA sequencingSporadic venous malformationsExome sequencingRNA sequencingPathway enrichmentGermline DNAMolecular consequencesTEK mutationsBlood DNANeurosurgical resectionMutationsPediatric casesVascular anomaliesGenetic testingMolecular implicationsSporadic casesEndothelial cellsDNATherapeutic targetSequenceMalformationsPopulation databaseAnimal models of Chiari malformation types 1 and 2: Mechanistic insights and translational challenges
Davalan W, Li Q, Hale A, Fan B, Duy P, Mehta N, Alper S, Kundishora A, Muñoz W, Dennis E, Allington G, Mekbib K, Butler W, Kahle K. Animal models of Chiari malformation types 1 and 2: Mechanistic insights and translational challenges. Experimental Neurology 2025, 395: 115473. PMID: 40992613, DOI: 10.1016/j.expneurol.2025.115473.Peer-Reviewed Original ResearchChiari malformationAnimal modelsCerebrospinal fluidChiari malformation type 1Review of animal modelsEtiology-specific therapyPreclinical animal modelsNeural tube defectsCranial base developmentCM pathogenesisFetal sheepCSF leakagePrenatal treatmentNeural tube closureTube defectsSpontaneous modelPathophysiological insightsTranslational relevanceType 1Cerebellar herniationHuman patientsSurgical modelCerebrospinal fluid physiologyTranslational challengesTranslational importanceThe RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development
Li X, Morgan C, Duy P, Evsen L, Hao L, Machavoine R, Belhous K, Ernest S, Denoyelle F, Mignot C, Brioude F, Parodi M, Li L, Huang H, Ponniah P, Kolanus W, Kahle K, Marlin S, Doetzlhofer A. The RNA-binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2505811122. PMID: 40892928, PMCID: PMC12435228, DOI: 10.1073/pnas.2505811122.Peer-Reviewed Original ResearchConceptsKnockout miceAssociated with hearing lossMonoallelic missense mutationsTiming of cell cycle exitHair cellsCochlear progenitor cellsSensory organ developmentInner ear morphogenesisStereotypic timeCell cycle exitOuter hair cell regionHair cell regionMechanosensory hair cellsSevere HLHair cell progenitorsHearing deficitsEarly otic developmentProgenitor cellsAuditory sensory organCell progenitorsEar morphogenesisGenetic studiesMissense mutationsCycle exitRisk genesLetter: Modulation of PI3K and MEK Signaling Reverse Vein of Galen Malformation
Hale A, Kahle K. Letter: Modulation of PI3K and MEK Signaling Reverse Vein of Galen Malformation. Neurosurgery 2025, 97: e134-e135. PMID: 40767514, DOI: 10.1227/neu.0000000000003681.Peer-Reviewed Original ResearchAn opportune time for targeted brain arteriovenous malformation therapy.
Hale A, Kalailingam P, Kundishora A, Reeves B, Brastianos P, Shih H, Jain R, Ning M, Stapleton C, Patel A, Smith E, Chapman P, Rabinov J, Kleinstiver B, Musolino P, Kahle K. An opportune time for targeted brain arteriovenous malformation therapy. Journal Of Neurosurgery 2025, 143: 1685-1688. PMID: 40644723, PMCID: PMC12477702, DOI: 10.3171/2025.4.jns25260.Peer-Reviewed Original ResearchMolecular hallmarks of hydrocephalus
Hale A, Zhou B, Rajan A, Duy P, Goolam M, Alper S, Lehtinen M, Lancaster M, Fame R, Kahle K. Molecular hallmarks of hydrocephalus. Science Translational Medicine 2025, 17: eadq1810. PMID: 40465691, PMCID: PMC12316480, DOI: 10.1126/scitranslmed.adq1810.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidBrain-CSF interfacePluripotent stem cell-derived cerebral organoidsStem cell dysfunctionAssociated with dilatationDisrupts synaptogenesisNeural stem cell dysfunctionMolecular classificationPharmacological treatmentCell dysfunctionImpaired neurogenesisBiomechanical instabilityHC subtypesGenome-widePleiotropic mechanismsCSF dynamicsNeural circuitryHydrocephalusEnvironmental insultsCerebral organoidsNeurodevelopmental comorbiditiesSingle-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus
Duy P, Kiziltug E, Greenberg A, Mehta N, Hao L, Fortes C, Mullany S, Fan B, Manichaikul A, Teich A, Chan D, Alper S, Hyman B, Arnold S, McKhann G, Frosch M, Kahle K. Single-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2412159122. PMID: 40324076, PMCID: PMC12087963, DOI: 10.1073/pnas.2412159122.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusNormal pressure hydrocephalusImmune dysregulationPeripheral bloodPressure hydrocephalusIdiopathic normal pressure hydrocephalus patientsProinflammatory alterationsVentricular CSFSingle-cell transcriptomicsINPH patientsCell populationsPatientsNeuroglial cellsCSFBloodHydrocephalusBaseline cognitive functionCognitive functionDysregulationMonocytes