Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes
Heer C, Elia J, Menon V, Johnson S, Arbelaez S, Friedman S, Lopez-Giraldez F, Sundaram R, Herzon S, Bindra R, Gueble S. Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes. NAR Cancer 2026, 8: zcaf052. PMID: 41522810, PMCID: PMC12783042, DOI: 10.1093/narcan/zcaf052.Peer-Reviewed Original Research
ConceptsDNA-damaging agentsDNA repair genesTranscription-coupled nucleotide excision repairCRISPR knockout screenFanconi anemia pathwayRepair genesClasses of DNA-damaging agentsDNA damage repairChemical diversityNucleotide excision repairKnockout screenMethylation lesionsRepair of lesionsDamaging agentsDDR pathwaysDSB repairGenetic instabilityLN229 glioma cellsExcision repairDamage repairDNA lesionsMonofunctional alkylating agentsTopoisomerase IDNAGenes