Research
The scientific focus of the Department of Microbial Pathogenesis is to study microbial pathogens through multidisciplinary approaches. Understanding the mechanisms by which microbial pathogens cause disease requires understanding the pathogenic microorganisms themselves as well as the cellular and immune responses they stimulate in the host. We are researching these interactions for a wide variety of important viral, bacterial and parasitic pathogens.
Primary Faculty Labs
- Galán/Lara-Tejero LabCampylobacter; Cell Biology; Immunity, Innate; Inflammation; Microbiology; Microscopy; Microscopy, Fluorescence; Salmonella; Cryoelectron Microscopy; Host-Pathogen Interactions; Microbiota; Analytical, Diagnostic and Therapeutic Techniques and Equipment; Type III Secretion Systems
- Goodman LabBacteria; Bacteroides; Symbiosis; Microbiota; Gastrointestinal Microbiome
- Groisman LabEcology; Biological Evolution; Genetics; Signal Transduction; Infectious Disease Medicine; Microbiota
- Ho LabGenetics; HIV; Immunotherapy; Microbiology; Host-Pathogen Interactions; Transcriptome; Epigenetic Repression
- Liu LabSignal Transduction; Cryoelectron Microscopy
- MacMicking LabCell Biology; Immunity, Innate; Interferons; Host-Pathogen Interactions
- Mothes LabBiophysics; HIV; Immune System; Retroviridae; SARS-CoV-2
- Pi LabAdaptation, Biological; Bacterial Infections; Signal Transduction; Clostridioides difficile; RNA-Binding Proteins; Host Microbial Interactions
- Rego LabBacteria; Cell Biology; Imaging, Three-Dimensional; Single-Cell Analysis
- Roy LabBacteria; Immune System; Macrophages; Protozoan Proteins; Legionella pneumophila; Coxiella burnetii; Vesicular Transport Proteins
Secondary Faculty Labs
- Ben Mamoun LabAntifungal Agents; Babesiosis; Malaria; Opportunistic Infections; Protozoan Infections; Diagnostic Techniques and Procedures; Infectious Disease Medicine; Drug Discovery; Translational Research, Biomedical
- Cappello LabAfrica, Western; Developing Countries; Ghana; Hookworm Infections; Malaria; Microbiology; Pediatrics; Public Health; Tropical Medicine; Global Health; Infectious Disease Medicine
- Crawford LabBacteria; Chemistry; Host-Pathogen Interactions
- Dela Cruz LabRespiratory Tract Infections; Pulmonary Disease, Chronic Obstructive
- Fikrig LabBacteria; Epidemiology; Lyme Disease; Parasitology; Public Health; Ticks; Viruses; West Nile virus; Global Health; Ehrlichiosis; Malaria Vaccines; Borrelia burgdorferi; Infectious Disease Medicine
- Johnson LabChlamydia trachomatis; Trachoma; Infectious Disease Medicine
- Kazmierczak LabBacterial Infections; Education, Medical, Graduate; Immunity, Innate; Microbiology; Pseudomonas; Biomedical Research; Host-Pathogen Interactions; Infectious Disease Medicine
- Kumar LabT-Lymphocytes; RNA Interference; Infectious Disease Medicine; Molecular Targeted Therapy
- Sutton LabHIV; Molecular Biology; Severe acute respiratory syndrome-related coronavirus; Infectious Disease Medicine
Research Community
The Department of Microbial Pathogenesis is part of a larger community: Microbiology Track Faculty in the Yale Combined Program in the Biological and Biomedical Sciences (BBS) and Microbiome Research at Yale.
Advanced Training
The impact of viruses such as AIDS and SARS-CoV-2 cannot be overstated; emerging microbial pathogens and the spread of antibiotic resistance are clear indications that infectious diseases remain a significant health problem. In the United States, infectious diseases are the third leading cause of death, and the situation is even more serious worldwide. A concerted effort is needed to deal with the growing threat of infectious diseases, and a central component of this effort is the training of scientists in the fields of microbiology and microbial pathogenesis.
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Controlling the activity of microbiome-encoded enzymes
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