Research Faculty
Associate Research Scientist
I am very happy to join in Mothes lab. I work on projects to understand the conformational changes of HIV-1 envelope glycoprotein on the surface of virus particles by parallel cryo Electron Tomography (CryoET) and single molecule Forster Resonance Energy Transfer (smFRET). I am also working on COVID19 research to understand the structural conformational change of spike protein of SARS-CoV-2. These projects will provide insights into not only basic science like how envelope mediates fusion of virus with host cell but also translational science aiding an vaccine and anti-retroviral therapies.Research Scientist
Dr. Pradeep Uchil is Research Scientist in the Department of Microbial Pathogenesis at Yale University. He received his PhD in Molecular Virology at the Indian Institute of Science, Bangalore, India, where he elucidated the architecture of flavivirus replication complexes. He completed his postdoctoral studies at Yale University with Prof. Walther Mothes in Retrovirus Cell Biology and Innate Immunity. Dr. Uchil studies how viruses replicate, spread, and interact with hosts to cause disease using mouse infection models. He has expertise in innate immunity, viral immunology, and elucidating virus-host interactions using imaging-based approaches that span multiple scales of resolution from the whole body to the ultrastructure. Specifically, he utilizes noninvasive whole-body bioluminescence imaging (BLI) as an unbiased guide for the identification and in-depth characterization of key tissues and...