Publications
2024
- The single-cell opioid responses in the context of HIV (SCORCH) consortium.Ament SA, Campbell RR, Lobo MK, Receveur JP, Agrawal K, Borjabad A, Byrareddy SN, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton KJ, Giglio M, Giorgi FM, Gok B, Guda C, Hadas E, Herb BR, Hu W, Huttner A, Ishmam MR, Jacobs MM, Kelschenbach J, Kim DW, Lee C, Liu S, Liu X, Madras BK, Mahurkar AA, Mash DC, Mukamel EA, Niu M, O'Connor RM, Pagan CM, Pang APS, Pillai P, Repunte-Canonigo V, Ruzicka WB, Stanley J, Tickle T, Tsai SA, Wang A, Wills L, Wilson AM, Wright SN, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng CS, Corley MJ, Fox HS, Gerstein M, Gummuluru S, Heiman M, Ho YC, Kellis M, Kenny PJ, Kluger Y, Milner TA, Moore DJ, Morgello S, Ndhlovu LC, Rana TM, Sanna PP, Satterlee JS, Sestan N, Spector SA, Spudich S, Tilgner HU, Volsky DJ, White OR, Williams DW, Zeng H. Mol Psychiatry. 2024 Jun 15; 2024 Jun 15. PMID: 38879719.
- A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in Mycobacterium smegmatis.Ng WL, Rego EH. mSphere. 2024 May 29; 2024 Apr 9. PMID: 38591887.
- Loss of function of metabolic traits in typhoidal Salmonella without apparent genome degradation.Machado LFM, Galán JE. mBio. 2024 May 8; 2024 Apr 4. PMID: 38572992.
- Proof-of-concept studies with a computationally designed M(pro) inhibitor as a synergistic combination regimen alternative to Paxlovid.Papini C, Ullah I, Ranjan AP, Zhang S, Wu Q, Spasov KA, Zhang C, Mothes W, Crawford JM, Lindenbach BD, Uchil PD, Kumar P, Jorgensen WL, Anderson KS. Proc Natl Acad Sci U S A. 2024 Apr 23; 2024 Apr 15. PMID: 38621119.
- Interferon-γ and infectious diseases: Lessons and prospects.Casanova JL, MacMicking JD, Nathan CF. Science. 2024 Apr 19; 2024 Apr 19. PMID: 38635718.
- Episymbiotic Saccharibacteria TM7x modulates the susceptibility of its host bacteria to phage infection and promotes their coexistence.Zhong Q, Liao B, Liu J, Shen W, Wang J, Wei L, Ma Y, Dong PT, Bor B, McLean JS, Chang Y, Shi W, Cen L, Wu M, Liu J, Li Y, He X, Le S. Proc Natl Acad Sci U S A. 2024 Apr 16; 2024 Apr 9. PMID: 38593079.
- Chaperone Hsp70 helps Salmonella survive infection-relevant stress by reducing protein synthesis.Chan C, Groisman EA. PLoS Biol. 2024 Apr; 2024 Apr 4. PMID: 38574172.
- HIF-1α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, -10 and -11.Su Y, Liu J, Tian Y, Dong H, Shi M, Zhang J, Li W, Huang Q, Xiang N, Wang C, Liu J, He L, Hu L, Haberman AM, Liu H, Yang X. Biomed Pharmacother. 2024 Apr; 2024 Mar 13. PMID: 38484558.
- Bioorthogonal click labeling of an amber-free HIV-1 provirus for in-virus single molecule imaging.Ao Y, Grover JR, Gifford L, Han Y, Zhong G, Katte R, Li W, Bhattacharjee R, Zhang B, Sauve S, Qin W, Ghimire D, Haque MA, Arthos J, Moradi M, Mothes W, Lemke EA, Kwong PD, Melikyan GB, Lu M. Cell Chem Biol. 2024 Mar 21; 2024 Jan 16. PMID: 38232732.
- Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens.Ullah I, Escudie F, Scandale I, Gilani Z, Gendron-Lepage G, Gaudette F, Mowbray C, Fraisse L, Bazin R, Finzi A, Mothes W, Kumar P, Chatelain E, Uchil PD. iScience. 2024 Mar 15; 2024 Jan 30. PMID: 38361624.
- Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.Benlarbi M, Richard J, Bourassa C, Tolbert WD, Chartrand-Lefebvre C, Gendron-Lepage G, Sylla M, El-Far M, Messier-Peet M, Guertin C, Turcotte I, Fromentin R, Verly MM, Prévost J, Clark A, Mothes W, Kaufmann DE, Maldarelli F, Chomont N, Bégin P, Tremblay C, Baril JG, Trottier B, Trottier S, Duerr R, Pazgier M, Durand M, Finzi A. J Infect Dis. 2024 Mar 14. PMID: 38035854.
- A pleiotropic role of sialidase in the pathogenicity of Porphyromonas gingivalis.Pham C, Guo S, Han X, Coleman L, Sze CW, Wang H, Liu J, Li C. Infect Immun. 2024 Mar 12; 2024 Feb 20. PMID: 38376159.
- Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors.Hikichi Y, Grover JR, Schäfer A, Mothes W, Freed EO. Sci Adv. 2024 Mar; 2024 Mar 1. PMID: 38427738.
- Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection.Zhu S, Bradfield CJ, Maminska A, Park ES, Kim BH, Kumar P, Huang S, Kim M, Zhang Y, Bewersdorf J, MacMicking JD. Science. 2024 Mar; 2024 Mar 1. PMID: 38422126.
- Structure of mavacamten-free human cardiac thick filaments within the sarcomere by cryoelectron tomography.Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA. Proc Natl Acad Sci U S A. 2024 Feb 27; 2024 Feb 22. PMID: 38386705.
- Outer membrane vesicles and the outer membrane protein OmpU govern Vibrio cholerae biofilm matrix assembly.Potapova A, Garvey W, Dahl P, Guo S, Chang Y, Schwechheimer C, Trebino MA, Floyd KA, Phinney BS, Liu J, Malvankar NS, Yildiz FH. mBio. 2024 Feb 14; 2024 Jan 11. PMID: 38206049.
- Integrating the gut microbiome and pharmacology.Verdegaal AA, Goodman AL. Sci Transl Med. 2024 Jan 31; 2024 Jan 31. PMID: 38295186.
- Bacterial flagella hijack type IV pili proteins to control motility.Liu X, Tachiyama S, Zhou X, Mathias RA, Bonny SQ, Khan MF, Xin Y, Roujeinikova A, Liu J, Ottemann KM. Proc Natl Acad Sci U S A. 2024 Jan 23; 2024 Jan 18. PMID: 38236729.
- Broadly conserved FlgV controls flagellar assembly and Borrelia burgdorferi dissemination in mice.Zamba-Campero M, Soliman D, Yu H, Lasseter AG, Chang YY, Liu J, Aravind L, Jewett MW, Storz G, Adams PP. bioRxiv. 2024 Jan 9; 2024 Jan 9. PMID: 38260563.
- A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in M. smegmatis.Ng WL, Rego EH. bioRxiv. 2024 Jan 3; 2024 Jan 3. PMID: 38260554.
2023
- Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C.Hansen T, Lee J, Reicher N, Ovadia G, Guo S, Guo W, Liu J, Braslavsky I, Rudich Y, Davies PL. Elife. 2023 Dec 18; 2023 Dec 18. PMID: 38109272.
- Spatial segregation and aging of metabolic processes underlie phenotypic heterogeneity in mycobacteria.Gwin CM, Gupta KR, Lu Y, Shao L, Rego EH. bioRxiv. 2023 Dec 2; 2023 Dec 2. PMID: 38076906.
- Metformin inhibits digestive proteases and impairs protein digestion in mice.Kelly CJ, Verdegaal AA, Anderson BW, Shaw WL, Bencivenga-Barry NA, Folta-Stogniew E, Goodman AL. J Biol Chem. 2023 Dec; 2023 Oct 19. PMID: 37863262.
- Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise.Hollander K, Chan AH, Frey KM, Hunker O, Ippolito JA, Spasov KA, Yeh YJ, Jorgensen WL, Ho YC, Anderson KS. Protein Sci. 2023 Dec. PMID: 37861472.
- FlgV forms a flagellar motor ring that is required for optimal motility of Helicobacter pylori.Botting JM, Tachiyama S, Gibson KH, Liu J, Starai VJ, Hoover TR. PLoS One. 2023; 2023 Nov 17. PMID: 37976320.
- Advancing the fitness of gut commensal bacteria.Groisman EA, Han W, Krypotou E. Science. 2023 Nov 17; 2023 Nov 16. PMID: 37972163.
- Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen.Ontai-Brenning A, Hamchand R, Crawford JM, Goodman AL. mBio. 2023 Nov 16; 2023 Nov 16. PMID: 37971266.
- Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence.Wei Y, Davenport TC, Collora JA, Ma HK, Pinto-Santini D, Lama J, Alfaro R, Duerr A, Ho YC. Immunity. 2023 Nov 14; 2023 Nov 2. PMID: 37922905.
- HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes.Li W, Qin Z, Nand E, Grunst MW, Grover JR, Bess JW Jr, Lifson JD, Zwick MB, Tagare HD, Uchil PD, Mothes W. Nature. 2023 Nov; 2023 Nov 22. PMID: 37993716.
- Clostridioides difficile ferrosome organelles combat nutritional immunity.Pi H, Sun R, McBride JR, Kruse ARS, Gibson-Corley KN, Krystofiak ES, Nicholson MR, Spraggins JM, Zhou Q, Skaar EP. Nature. 2023 Nov; 2023 Nov 15. PMID: 37968387.
- Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C.Hansen T, Lee JC, Reicher N, Ovadia G, Guo S, Guo W, Liu J, Braslavsky I, Rudich Y, Davies PL. bioRxiv. 2023 Oct 26; 2023 Oct 26. PMID: 37577566.
- Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella.Lian H, Park D, Chen M, Schueder F, Lara-Tejero M, Liu J, Galán JE. Nat Microbiol. 2023 Oct; 2023 Aug 28. PMID: 37640963.
- Advancing evolution: Bacteria break down gene silencer to express horizontally acquired genes.Groisman EA, Choi J. Bioessays. 2023 Oct; 2023 Aug 3. PMID: 37533411.
- Immunogenicity and Pre-Clinical Efficacy of an OMV-Based SARS-CoV-2 Vaccine.Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Croia L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G. Vaccines (Basel). 2023 Sep 29; 2023 Sep 29. PMID: 37896949.
- How Bacterial Pathogens Coordinate Appetite with Virulence.Pokorzynski ND, Groisman EA. Microbiol Mol Biol Rev. 2023 Sep 26; 2023 Jun 26. PMID: 37358444.
- Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels.Wong M, Wei Y, Ho YC. Curr Opin HIV AIDS. 2023 Sep 1; 2023 Jul 17. PMID: 37535039.
- Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments.Huang X, Torre I, Chiappi M, Yin Z, Vydyanath A, Cao S, Raschdorf O, Beeby M, Quigley B, de Tombe PP, Liu J, Morris EP, Luther PK. J Muscle Res Cell Motil. 2023 Sep; 2023 Apr 28. PMID: 37115473.
- Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M. Nat Commun. 2023 Jul 20; 2023 Jul 20. PMID: 37474505.
- PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.Xu D, Jiang W, Wu L, Gaudet RG, Park ES, Su M, Cheppali SK, Cheemarla NR, Kumar P, Uchil PD, Grover JR, Foxman EF, Brown CM, Stansfeld PJ, Bewersdorf J, Mothes W, Karatekin E, Wilen CB, MacMicking JD. Nature. 2023 Jul; 2023 Jul 12. PMID: 37438530.
- Integration site-dependent HIV-1 promoter activity shapes host chromatin conformation.Collora JA, Ho YC. Genome Res. 2023 Jun; 2023 Jun 9. PMID: 37295842.
- A peek inside the 2023 Bacterial Locomotion and Signal Transduction (BLAST) conference.Hadjifrangiskou M, Liu J, Ottemann KM, Roujeinikova A. Trends Microbiol. 2023 Jun; 2023 Apr 29. PMID: 37127442.
- In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer's disease.Zhang J, Wang J, Xu X, You Z, Huang Q, Huang Y, Guo Q, Guan Y, Zhao J, Liu J, Xu W, Deng Y, Xie F, Li B. J Cereb Blood Flow Metab. 2023 Jun; 2023 Jan 30. PMID: 36718002.
- Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine.Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Lascio GD, Tamburini S, Caproni E, Croia L, Ravà M, Fumagalli V, Lucia PD, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G. Res Sq. 2023 May 25; 2023 May 25. PMID: 37292970.
- Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models.Lorenzo MM, Marín-López A, Chiem K, Jimenez-Cabello L, Ullah I, Utrilla-Trigo S, Calvo-Pinilla E, Lorenzo G, Moreno S, Ye C, Park JG, Matía A, Brun A, Sánchez-Puig JM, Nogales A, Mothes W, Uchil PD, Kumar P, Ortego J, Fikrig E, Martinez-Sobrido L, Blasco R. Vaccines (Basel). 2023 May 21; 2023 May 21. PMID: 37243110.
- Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.Richard J, Prévost J, Bourassa C, Brassard N, Boutin M, Benlarbi M, Goyette G, Medjahed H, Gendron-Lepage G, Gaudette F, Chen HC, Tolbert WD, Smith AB 3rd, Pazgier M, Dubé M, Clark A, Mothes W, Kaufmann DE, Finzi A. Cell Chem Biol. 2023 May 18; 2023 Mar 22. PMID: 36958337.
- Infection leaves a genetic and functional mark on the gut population of a commensal bacterium.Tawk C, Lim B, Bencivenga-Barry NA, Lees HJ, Ramos RJF, Cross J, Goodman AL. Cell Host Microbe. 2023 May 10; 2023 Apr 28. PMID: 37119822.
- Cross-feeding in the gut microbiome: Ecology and mechanisms.Culp EJ, Goodman AL. Cell Host Microbe. 2023 Apr 12. PMID: 37054671.
- DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification.Hao Q, Zhan C, Lian C, Luo S, Cao W, Wang B, Xie X, Ye X, Gui T, Voena C, Pighi C, Wang Y, Tian Y, Wang X, Dai P, Cai Y, Liu X, Ouyang S, Sun S, Hu Q, Liu J, Ye Y, Zhao J, Lu A, Wang JY, Huang C, Su B, Meng FL, Chiarle R, Pan-Hammarström Q, Yeap LS. Sci Immunol. 2023 Mar 31; 2023 Mar 24. PMID: 36961908.
- Bacteria require phase separation for fitness in the mammalian gut.Krypotou E, Townsend GE, Gao X, Tachiyama S, Liu J, Pokorzynski ND, Goodman AL, Groisman EA. Science. 2023 Mar 17; 2023 Mar 16. PMID: 36927025.
- The Coxiella burnetii effector EmcB is a deubiquitinase that inhibits RIG-I signaling.Duncan-Lowey J, Crabill E, Jarret A, Reed SCO, Roy CR. Proc Natl Acad Sci U S A. 2023 Mar 14; 2023 Mar 9. PMID: 36893270.
- Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection.Ganesan S, Alvarez NN, Steiner S, Fowler KM, Corona AK, Roy CR. mBio. 2023 Feb 28; 2023 Feb 2. PMID: 36728431.
- Anti-σ(28) Factor FlgM Regulates Flagellin Gene Expression and Flagellar Polarity of Treponema denticola.Kurniyati K, Chang Y, Guo W, Liu J, Malkowski MG, Li C. J Bacteriol. 2023 Feb 22; 2023 Jan 30. PMID: 36715541.
- Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.Chen Y, Prévost J, Ullah I, Romero H, Lisi V, Tolbert WD, Grover JR, Ding S, Gong SY, Beaudoin-Bussières G, Gasser R, Benlarbi M, Vézina D, Anand SP, Chatterjee D, Goyette G, Grunst MW, Yang Z, Bo Y, Zhou F, Béland K, Bai X, Zeher AR, Huang RK, Nguyen DN, Sherburn R, Wu D, Piszczek G, Paré B, Matthies D, Xia D, Richard J, Kumar P, Mothes W, Côté M, Uchil PD, Lavallée VP, Smith MA, Pazgier M, Haddad E, Finzi A. iScience. 2023 Jan 20; 2022 Dec 9. PMID: 36514310.
- The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice.Ullah I, Beaudoin-Bussières G, Symmes K, Cloutier M, Ducas E, Tauzin A, Laumaea A, Grunst MW, Dionne K, Richard J, Bégin P, Mothes W, Kumar P, Bazin R, Finzi A, Uchil PD. Cell Rep Med. 2023 Jan 17; 2022 Dec 29. PMID: 36584683.
- Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity.Han W, Peng BZ, Wang C, Townsend GE 2nd, Barry NA, Peske F, Goodman AL, Liu J, Rodnina MV, Groisman EA. EMBO J. 2023 Jan 16; 2022 Dec 6. PMID: 36472247.
- Dietary sugars silence the master regulator of carbohydrate utilization in human gut Bacteroides species.Pearce VH, Groisman EA, Townsend GE 2nd. Gut Microbes. 2023 Jan-Dec. PMID: 37358144.
2022
- Assembly and architecture of the type III secretion sorting platform.Soto JE, Galán JE, Lara-Tejero M. Proc Natl Acad Sci U S A. 2022 Dec 20; 2022 Dec 13. PMID: 36512499.
- Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates.Wei Y, Ho YC. Mol Cell. 2022 Dec 15. PMID: 36525953.
- Rewiring the logic board of IFN signaling.MacMicking JD. Sci Signal. 2022 Dec 13; 2022 Dec 13. PMID: 36512642.
- An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria.Gupta KR, Gwin CM, Rahlwes KC, Biegas KJ, Wang C, Park JH, Liu J, Swarts BM, Morita YS, Rego EH. Elife. 2022 Nov 8; 2022 Nov 8. PMID: 36346214.
- Cryo-EM structures of prefusion SIV envelope trimer.Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess JW Jr, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD. Nat Struct Mol Biol. 2022 Nov; 2022 Nov 7. PMID: 36344847.
- Developmental Transitions Coordinate Assembly of the Coxiella burnetii Dot/Icm Type IV Secretion System.Park D, Steiner S, Shao M, Roy CR, Liu J. Infect Immun. 2022 Oct 20; 2022 Oct 3. PMID: 36190257.
- Degradation of gene silencer is essential for expression of foreign genes and bacterial colonization of the mammalian gut.Choi J, Schmukler M, Groisman EA. Proc Natl Acad Sci U S A. 2022 Oct 4; 2022 Sep 26. PMID: 36161931.
- A Tripartite Efflux System Affects Flagellum Stability in Helicobacter pylori.Gibson K, Chu JK, Zhu S, Nguyen D, Mrázek J, Liu J, Hoover TR. Int J Mol Sci. 2022 Oct 1; 2022 Oct 1. PMID: 36232924.
- Editorial: Biological rotary nanomotors.Manson MD, Nan B, Lele PP, Liu J, Duncan TM. Front Microbiol. 2022; 2022 Sep 21. PMID: 36212881.
- Identification and Characterization of the Alternative σ(28) Factor in Treponema denticola.Kurniyati K, Chang Y, Liu J, Li C. J Bacteriol. 2022 Sep 20; 2022 Aug 31. PMID: 36043861.
- Transcriptome of Epibiont Saccharibacteria Nanosynbacter lyticus Strain TM7x During the Establishment of Symbiosis.Hendrickson EL, Bor B, Kerns KA, Lamont EI, Chang Y, Liu J, Cen L, Schulte F, Hardt M, Shi W, He X, McLean JS. J Bacteriol. 2022 Sep 20; 2022 Aug 17. PMID: 35975994.
- Exploitation of a Bacterium-Encoded Lytic Transglycosylase by a Human Oral Lytic Phage To Facilitate Infection.Cen L, Chang Y, Bedree JK, Ma Y, Zhong Q, Utter DR, Dong PT, Lux R, Bor B, Liu J, McLean JS, Le S, He X. J Virol. 2022 Sep 14; 2022 Aug 24. PMID: 36000841.
- Transcriptional and functional characterizations of multiple flagellin genes in spirochetes.Kurniyati K, Chang Y, Liu J, Li C. Mol Microbiol. 2022 Sep; 2022 Jul 18. PMID: 35776658.
- In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts.Cai S, Wu Y, Guillén-Samander A, Hancock-Cerutti W, Liu J, De Camilli P. Proc Natl Acad Sci U S A. 2022 Jul 19; 2022 Jul 13. PMID: 35858323.
- Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. Sci Adv. 2022 Jul 15; 2022 Jul 13. PMID: 35857504.
- VE607 stabilizes SARS-CoV-2 Spike in the "RBD-up" conformation and inhibits viral entry.Ding S, Ullah I, Gong SY, Grover JR, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Gaudette F, Richard J, Yang D, Smith AB 3rd, Pazgier M, Côté M, Abrams C, Kumar P, Mothes W, Uchil PD, Finzi A, Baron C. iScience. 2022 Jul 15; 2022 Jun 3. PMID: 35677392.
- Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen.Pedersen SF, Collora JA, Kim RN, Yang K, Razmi A, Catalano AA, Yeh YJ, Mounzer K, Tebas P, Montaner LJ, Ho YC. J Virol. 2022 Jul 13; 2022 Jun 22. PMID: 35730977.
- Increasing the resilience of plant immunity to a warming climate.Kim JH, Castroverde CDM, Huang S, Li C, Hilleary R, Seroka A, Sohrabi R, Medina-Yerena D, Huot B, Wang J, Nomura K, Marr SK, Wildermuth MC, Chen T, MacMicking JD, He SY. Nature. 2022 Jul; 2022 Jun 29. PMID: 35768511.
- Mycobacterial serine/threonine phosphatase PstP is phosphoregulated and localized to mediate control of cell wall metabolism.Shamma F, Rego EH, Boutte CC. Mol Microbiol. 2022 Jul; 2022 Jun 20. PMID: 35670057.
- Cell Wall Damage Reveals Spatial Flexibility in Peptidoglycan Synthesis and a Nonredundant Role for RodA in Mycobacteria.Melzer ES, Kado T, García-Heredia A, Gupta KR, Meniche X, Morita YS, Sassetti CM, Rego EH, Siegrist MS. J Bacteriol. 2022 Jun 21; 2022 May 11. PMID: 35543537.
- Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones.Collora JA, Liu R, Pinto-Santini D, Ravindra N, Ganoza C, Lama JR, Alfaro R, Chiarella J, Spudich S, Mounzer K, Tebas P, Montaner LJ, van Dijk D, Duerr A, Ho YC. Immunity. 2022 Jun 14; 2022 Mar 22. PMID: 35320704.
- Author Correction: Targeted tumour theranostics in mice via carbon quantum dots structurally mimicking large amino acids.Li S, Su W, Wu H, Yuan T, Yuan C, Liu J, Deng G, Gao X, Chen Z, Bao Y, Yuan F, Zhou S, Tan H, Li Y, Li X, Fan L, Zhu J, Chen AT, Liu F, Zhou Y, Li M, Zhai X, Zhou J. Nat Biomed Eng. 2022 Jun. PMID: 35064254.
- The Bacterial Flagellar Motor: Insights Into Torque Generation, Rotational Switching, and Mechanosensing.Guo S, Liu J. Front Microbiol. 2022; 2022 May 30. PMID: 35711788.
- Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells.Chang SJ, Hsu YT, Chen Y, Lin YY, Lara-Tejero M, Galan JE. Elife. 2022 May 17; 2022 May 17. PMID: 35579416.
- Cancer Microbiology.DiMaio D, Emu B, Goodman AL, Mothes W, Justice A. J Natl Cancer Inst. 2022 May 9. PMID: 34850062.
- Gut Commensal Bacteroidetes Encode a Novel Class of Vitamin B(12)-Binding Proteins.Putnam EE, Abellon-Ruiz J, Killinger BJ, Rosnow JJ, Wexler AG, Folta-Stogniew E, Wright AT, van den Berg B, Goodman AL. mBio. 2022 Apr 26; 2022 Mar 1. PMID: 35227073.
- ZNF117 regulates glioblastoma stem cell differentiation towards oligodendroglial lineage.Liu J, Wang X, Chen AT, Gao X, Himes BT, Zhang H, Chen Z, Wang J, Sheu WC, Deng G, Xiao Y, Zou P, Zhang S, Liu F, Zhu Y, Fan R, Patel TR, Saltzman WM, Zhou J. Nat Commun. 2022 Apr 22; 2022 Apr 22. PMID: 35459228.
- Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.Wang F, Cvirkaite-Krupovic V, Vos M, Beltran LC, Kreutzberger MAB, Winter JM, Su Z, Liu J, Schouten S, Krupovic M, Egelman EH. Cell. 2022 Apr 14; 2022 Mar 23. PMID: 35325592.
- TCR-mimic bispecific antibodies to target the HIV-1 reservoir.Sengupta S, Board NL, Wu F, Moskovljevic M, Douglass J, Zhang J, Reinhold BR, Duke-Cohan J, Yu J, Reed MC, Tabdili Y, Azurmendi A, Fray EJ, Zhang H, Hsiue EH, Jenike K, Ho YC, Gabelli SB, Kinzler KW, Vogelstein B, Zhou S, Siliciano JD, Sadegh-Nasseri S, Reinherz EL, Siliciano RF. Proc Natl Acad Sci U S A. 2022 Apr 12; 2022 Apr 8. PMID: 35394875.
- Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2.Cale EM, Driscoll JI, Lee M, Gorman J, Zhou T, Lu M, Geng H, Lai YT, Chuang GY, Doria-Rose NA, Mothes W, Kwong PD, Mascola JR. J Biol Chem. 2022 Apr; 2022 Mar 10. PMID: 35283191.
- FliL ring enhances the function of periplasmic flagella.Guo S, Xu H, Chang Y, Motaleb MA, Liu J. Proc Natl Acad Sci U S A. 2022 Mar 15; 2022 Mar 7. PMID: 35254893.
- Differential synthesis of novel small protein times Salmonella virulence program.Salvail H, Choi J, Groisman EA. PLoS Genet. 2022 Mar; 2022 Mar 4. PMID: 35245279.
- A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection.Beaudoin-Bussières G, Chen Y, Ullah I, Prévost J, Tolbert WD, Symmes K, Ding S, Benlarbi M, Gong SY, Tauzin A, Gasser R, Chatterjee D, Vézina D, Goyette G, Richard J, Zhou F, Stamatatos L, McGuire AT, Charest H, Roger M, Pozharski E, Kumar P, Mothes W, Uchil PD, Pazgier M, Finzi A. Cell Rep. 2022 Feb 15; 2022 Jan 25. PMID: 35123652.
- Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila.Macé K, Meir A, Lukoyanova N, Liu L, Chetrit D, Hospenthal MK, Roy CR, Waksman G. Mol Microbiol. 2022 Feb; 2021 Dec 6. PMID: 34816517.
- The flagellar motor protein FliL forms a scaffold of circumferentially positioned rings required for stator activation.Tachiyama S, Chan KL, Liu X, Hathroubi S, Peterson B, Khan MF, Ottemann KM, Liu J, Roujeinikova A. Proc Natl Acad Sci U S A. 2022 Jan 25. PMID: 35046042.
- The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist.Collora JA, Ho YC. Cell. 2022 Jan 20. PMID: 35063069.
- Targeted disruption of tumor vasculature via polyphenol nanoparticles to improve brain cancer treatment.Liu F, Peng B, Li M, Ma J, Deng G, Zhang S, Sheu WC, Zou P, Wu H, Liu J, Chen AT, Mohammed FS, Zhou J. Cell Rep Phys Sci. 2022 Jan 19; 2021 Dec 13. PMID: 35199059.
- Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. Cell Rep. 2022 Jan 11; 2021 Dec 15. PMID: 34971573.
2021
- Characterization of the Flagellar Collar Reveals Structural Plasticity Essential for Spirochete Motility.Chang Y, Xu H, Motaleb MA, Liu J. mBio. 2021 Dec 21; 2021 Nov 23. PMID: 34809456.
- A multidimensional HIV-1 persistence model for clonal expansion and viral rebound in vitro.Eshetu A, Ho YC. Cell Rep Methods. 2021 Dec 20; 2021 Dec 20. PMID: 35475216.
- Openness weighted association studies: leveraging personal genome information to prioritize non-coding variants.Song S, Shan N, Wang G, Yan X, Liu JS, Hou L. Bioinformatics. 2021 Dec 11. PMID: 34260700.
- Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence.Schultheis A, Sanchez M, Pedersen S, Kyriakides T, Ho YC, Kluger Y, Springer SA. Contemp Clin Trials Commun. 2021 Dec; 2021 Nov 11. PMID: 34825103.
- Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. bioRxiv. 2021 Nov 24; 2021 Nov 24. PMID: 34845451.
- RNA chaperone activates Salmonella virulence program during infection.Choi J, Salvail H, Groisman EA. Nucleic Acids Res. 2021 Nov 18. PMID: 34751407.