Choukri Ben Mamoun, PhD

John F. Enders Professor of Medicine (Infectious Diseases) and of Pathology and of Microbial Pathogenesis

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Appointments

Infectious Diseases

Primary

Microbial Pathogenesis

Secondary

Pathology

Secondary

Additional Titles

Affiliated Faculty, Yale Institute for Global Health

About

Titles

John F. Enders Professor of Medicine (Infectious Diseases) and of Pathology and of Microbial Pathogenesis

Affiliated Faculty, Yale Institute for Global Health

Appointments

Infectious Diseases
Professor
Primary
Infectious Diseases
Microbial Pathogenesis
Professor
Secondary
Microbial Pathogenesis
Pathology
Professor
Secondary
Pathology

Education & Training

PhD: University of Paris (1996)

Research

Overview

Medical Research Interests

Antifungal Agents; Babesiosis; Diagnostic Techniques and Procedures; Drug Discovery; Infectious Disease Medicine; Malaria; Opportunistic Infections; Protozoan Infections; Translational Research, Biomedical

ORCID
0000-0001-5028-1400

Research at a Glance

Yale Co-Authors

Frequent collaborators of Choukri Ben Mamoun's published research.

Pallavi Singh
Former YSM
View 15 Common Publications
Jae-Yeon Choi
Former YSM
View 14 Common Publications
Anasuya Pal, PhD
View Full Profile
View 13 Common Publications
Pratap Vydyam
Former YSM
View 10 Common Publications
Lauren Lawres, MSPH
View Full Profile
View 7 Common Publications
Shalev Gihaz
Former YSM
View 4 Common Publications

Publications

Featured Publications

Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis
Vydyam P, Chand M, Pou S, Winter R, Liebman K, Nilsen A, Doggett J, Riscoe M, Mamoun C. Effectiveness of Two New Endochin-like Quinolones, ELQ-596 and ELQ-650, in Experimental Mouse Models of Human Babesiosis. ACS Infectious Diseases 2024, 10: 1405-1413. PMID: 38563132, PMCID: PMC11127568, DOI: 10.1021/acsinfecdis.4c00143.
Peer-Reviewed Original Research
MeSH Keywords
Tafenoquine-Atovaquone Combination Achieves Radical Cure and Confers Sterile Immunity in Experimental Models of Human Babesiosis
Vydyam P, Pal A, Renard I, Chand M, Kumari V, Gennaro J, Mamoun C. Tafenoquine-Atovaquone Combination Achieves Radical Cure and Confers Sterile Immunity in Experimental Models of Human Babesiosis. Journal Of Infectious Diseases 2024, 229: 161-172. PMID: 38169301, PMCID: PMC10786256, DOI: 10.1093/infdis/jiad315.
Peer-Reviewed Original Research
MeSH Keywords
Babesia duncani multi-omics identifies virulence factors and drug targets
Singh P, Lonardi S, Liang Q, Vydyam P, Khabirova E, Fang T, Gihaz S, Thekkiniath J, Munshi M, Abel S, Ciampossin L, Batugedara G, Gupta M, Lu X, Lenz T, Chakravarty S, Cornillot E, Hu Y, Ma W, Gonzalez L, Sánchez S, Estrada K, Sánchez-Flores A, Montero E, Harb O, Le Roch K, Mamoun C. Babesia duncani multi-omics identifies virulence factors and drug targets. Nature Microbiology 2023, 8: 845-859. PMID: 37055610, PMCID: PMC10159843, DOI: 10.1038/s41564-023-01360-8.
Peer-Reviewed Original Research
MeSH Keywords
Spermidine is a key polyamine required by intracellular parasites for survival within host erythrocytes
Singh P, Choi J, Cornillot E, Mamoun C. Spermidine is a key polyamine required by intracellular parasites for survival within host erythrocytes. Science Advances 2025, 11: eadv2397. PMID: 40531988, PMCID: PMC12175890, DOI: 10.1126/sciadv.adv2397.
Peer-Reviewed Original Research
MeSH Keywords
A fluorescence-based assay for measuring aminopropyltransferase activity
Singh P, Choi J, Ben Mamoun C. A fluorescence-based assay for measuring aminopropyltransferase activity. Methods In Enzymology 2025, 715: 363-388. PMID: 40382149, DOI: 10.1016/bs.mie.2025.01.067.
Chapters
MeSH Keywords
A fluorescence-based assay for measuring polyamine biosynthesis aminopropyl transferase–mediated catalysis
Singh P, Choi J, Wang W, Lam T, Lechner P, Vanderwal C, Pou S, Nilsen A, Mamoun C. A fluorescence-based assay for measuring polyamine biosynthesis aminopropyl transferase–mediated catalysis. Journal Of Biological Chemistry 2024, 300: 107832. PMID: 39342998, PMCID: PMC11541840, DOI: 10.1016/j.jbc.2024.107832.
Peer-Reviewed Original Research
A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria
Chahine Z, Abel S, Hollin T, Barnes G, Chung J, Daub M, Renard I, Choi J, Vydyam P, Pal A, Alba-Argomaniz M, Banks C, Kirkwood J, Saraf A, Camino I, Castaneda P, Cuevas M, De Mercado-Arnanz J, Fernandez-Alvaro E, Garcia-Perez A, Ibarz N, Viera-Morilla S, Prudhomme J, Joyner C, Bei A, Florens L, Mamoun C, Vanderwal C, Le Roch K. A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria. Science 2024, 385: eadm7966-eadm7966. PMID: 39325875, PMCID: PMC11793105, DOI: 10.1126/science.adm7966.
Peer-Reviewed Original Research
MeSH Keywords
Polypharmacology in malaria treatment: single drugs, multiple mechanisms, greater impact
Milić M, Obi P, Vanderwal C, Ben Mamoun C, Le Roch K. Polypharmacology in malaria treatment: single drugs, multiple mechanisms, greater impact. Trends In Parasitology 2026, 42: 222-236. PMID: 41846229, DOI: 10.1016/j.pt.2026.02.004.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Babesia hegotelforum sp. nov., a zoonotic Babesia species previously referred to as Babesia sp. MO1
Singh P, Estrada K, Gonzalez L, Grande R, Sánchez-Prieto S, Cornillot E, Harb O, Sanchez-Flores A, Montero E, Le Roch K, Lonardi S, Mamoun C. Babesia hegotelforum sp. nov., a zoonotic Babesia species previously referred to as Babesia sp. MO1. Emerging Microbes & Infections 2026, 15: 2637280. PMID: 41790956, PMCID: PMC12973771, DOI: 10.1080/22221751.2026.2637280.
Peer-Reviewed Original Research
MeSH Keywords

2026

Characterization of vesicle-associated exported immunodominant antigens of the human pathogen Babesia duncani.
Singh P, Pal A, Choi J, Chand M, Vydyam P, Kumari G, Ben Mamoun C. Characterization of vesicle-associated exported immunodominant antigens of the human pathogen Babesia duncani. Infection And Immunity 2026, e0076325. PMID: 42234515, DOI: 10.1128/iai.00763-25.
Peer-Reviewed Original Research

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News & Links

Media

The image shows the final developmental stage (schizont) of the human malaria parasite Plasmodium falciparum during its intra-erythrocytic life cycle in human red blood cells.

News

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Appointments

Additional Titles

Titles

Appointments

Infectious Diseases

Microbial Pathogenesis

Pathology

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

ORCID

Research at a Glance

Yale Co-Authors

Pallavi Singh

Jae-Yeon Choi

Anasuya Pal, PhD

Pratap Vydyam

Lauren Lawres, MSPH

Shalev Gihaz

Publications

Featured Publications

2026

Media

Malaria parasite in a human red blood cell

News

Ben Mamoun Named the John F. Enders Professor of Medicine

How Parasites—and a Bit of Serendipity—Led to a Powerful New Drug Discovery Tool: A Q&A with Choukri Ben Mamoun

Noninvasive malaria test could be global game changer

Further Babesiosis Biology, Pathogenicity Research Underway at Yale