Publications
2024
- Proof-of-concept studies with a computationally designed M(pro) inhibitor as a synergistic combination regimen alternative to Paxlovid.Papini C, Ullah I, Ranjan AP, Zhang S, Wu Q, Spasov KA, Zhang C, Mothes W, Crawford JM, Lindenbach BD, Uchil PD, Kumar P, Jorgensen WL, Anderson KS. Proc Natl Acad Sci U S A. 2024 Apr 23; 2024 Apr 15. PMID: 38621119.
- Interferon-γ and infectious diseases: Lessons and prospects.Casanova JL, MacMicking JD, Nathan CF. Science. 2024 Apr 19; 2024 Apr 19. PMID: 38635718.
- Episymbiotic Saccharibacteria TM7x modulates the susceptibility of its host bacteria to phage infection and promotes their coexistence.Zhong Q, Liao B, Liu J, Shen W, Wang J, Wei L, Ma Y, Dong PT, Bor B, McLean JS, Chang Y, Shi W, Cen L, Wu M, Liu J, Li Y, He X, Le S. Proc Natl Acad Sci U S A. 2024 Apr 16; 2024 Apr 9. PMID: 38593079.
- A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in Mycobacterium smegmatis.Ng WL, Rego EH. mSphere. 2024 Apr 9; 2024 Apr 9. PMID: 38591887.
- Loss of function of metabolic traits in typhoidal Salmonella without apparent genome degradation.Machado LFM, Galán JE. mBio. 2024 Apr 4; 2024 Apr 4. PMID: 38572992.
- Bioorthogonal click labeling of an amber-free HIV-1 provirus for in-virus single molecule imaging.Ao Y, Grover JR, Gifford L, Han Y, Zhong G, Katte R, Li W, Bhattacharjee R, Zhang B, Sauve S, Qin W, Ghimire D, Haque MA, Arthos J, Moradi M, Mothes W, Lemke EA, Kwong PD, Melikyan GB, Lu M. Cell Chem Biol. 2024 Mar 21; 2024 Jan 16. PMID: 38232732.
- Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens.Ullah I, Escudie F, Scandale I, Gilani Z, Gendron-Lepage G, Gaudette F, Mowbray C, Fraisse L, Bazin R, Finzi A, Mothes W, Kumar P, Chatelain E, Uchil PD. iScience. 2024 Mar 15; 2024 Jan 30. PMID: 38361624.
- Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.Benlarbi M, Richard J, Bourassa C, Tolbert WD, Chartrand-Lefebvre C, Gendron-Lepage G, Sylla M, El-Far M, Messier-Peet M, Guertin C, Turcotte I, Fromentin R, Verly MM, Prévost J, Clark A, Mothes W, Kaufmann DE, Maldarelli F, Chomont N, Bégin P, Tremblay C, Baril JG, Trottier B, Trottier S, Duerr R, Pazgier M, Durand M, Finzi A. J Infect Dis. 2024 Mar 14. PMID: 38035854.
- A pleiotropic role of sialidase in the pathogenicity of Porphyromonas gingivalis.Pham C, Guo S, Han X, Coleman L, Sze CW, Wang H, Liu J, Li C. Infect Immun. 2024 Mar 12; 2024 Feb 20. PMID: 38376159.
- Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors.Hikichi Y, Grover JR, Schäfer A, Mothes W, Freed EO. Sci Adv. 2024 Mar; 2024 Mar 1. PMID: 38427738.
- Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection.Zhu S, Bradfield CJ, Maminska A, Park ES, Kim BH, Kumar P, Huang S, Kim M, Zhang Y, Bewersdorf J, MacMicking JD. Science. 2024 Mar; 2024 Mar 1. PMID: 38422126.
- Structure of mavacamten-free human cardiac thick filaments within the sarcomere by cryoelectron tomography.Chen L, Liu J, Rastegarpouyani H, Janssen PML, Pinto JR, Taylor KA. Proc Natl Acad Sci U S A. 2024 Feb 27; 2024 Feb 22. PMID: 38386705.
- Outer membrane vesicles and the outer membrane protein OmpU govern Vibrio cholerae biofilm matrix assembly.Potapova A, Garvey W, Dahl P, Guo S, Chang Y, Schwechheimer C, Trebino MA, Floyd KA, Phinney BS, Liu J, Malvankar NS, Yildiz FH. mBio. 2024 Feb 14; 2024 Jan 11. PMID: 38206049.
- Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters.Di Pietro C, Haberman AM, Lindenbach BD, Smith PC, Bruscia EM, Allore HG, Vander Wyk B, Tyagi A, Zeiss CJ. Viruses. 2024 Feb 3; 2024 Feb 3. PMID: 38400021.
- Integrating the gut microbiome and pharmacology.Verdegaal AA, Goodman AL. Sci Transl Med. 2024 Jan 31; 2024 Jan 31. PMID: 38295186.
- Bacterial flagella hijack type IV pili proteins to control motility.Liu X, Tachiyama S, Zhou X, Mathias RA, Bonny SQ, Khan MF, Xin Y, Roujeinikova A, Liu J, Ottemann KM. Proc Natl Acad Sci U S A. 2024 Jan 23; 2024 Jan 18. PMID: 38236729.
- Broadly conserved FlgV controls flagellar assembly and Borrelia burgdorferi dissemination in mice.Zamba-Campero M, Soliman D, Yu H, Lasseter AG, Chang YY, Liu J, Aravind L, Jewett MW, Storz G, Adams PP. bioRxiv. 2024 Jan 9; 2024 Jan 9. PMID: 38260563.
- A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in M. smegmatis.Ng WL, Rego EH. bioRxiv. 2024 Jan 3; 2024 Jan 3. PMID: 38260554.
2023
- Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C.Hansen T, Lee J, Reicher N, Ovadia G, Guo S, Guo W, Liu J, Braslavsky I, Rudich Y, Davies PL. Elife. 2023 Dec 18; 2023 Dec 18. PMID: 38109272.
- Spatial segregation and aging of metabolic processes underlie phenotypic heterogeneity in mycobacteria.Gwin CM, Gupta KR, Lu Y, Shao L, Rego EH. bioRxiv. 2023 Dec 2; 2023 Dec 2. PMID: 38076906.
- Metformin inhibits digestive proteases and impairs protein digestion in mice.Kelly CJ, Verdegaal AA, Anderson BW, Shaw WL, Bencivenga-Barry NA, Folta-Stogniew E, Goodman AL. J Biol Chem. 2023 Dec; 2023 Oct 19. PMID: 37863262.
- Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise.Hollander K, Chan AH, Frey KM, Hunker O, Ippolito JA, Spasov KA, Yeh YJ, Jorgensen WL, Ho YC, Anderson KS. Protein Sci. 2023 Dec. PMID: 37861472.
- FlgV forms a flagellar motor ring that is required for optimal motility of Helicobacter pylori.Botting JM, Tachiyama S, Gibson KH, Liu J, Starai VJ, Hoover TR. PLoS One. 2023; 2023 Nov 17. PMID: 37976320.
- Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen.Ontai-Brenning A, Hamchand R, Crawford JM, Goodman AL. mBio. 2023 Nov 16; 2023 Nov 16. PMID: 37971266.
- Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence.Wei Y, Davenport TC, Collora JA, Ma HK, Pinto-Santini D, Lama J, Alfaro R, Duerr A, Ho YC. Immunity. 2023 Nov 14; 2023 Nov 2. PMID: 37922905.
- HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes.Li W, Qin Z, Nand E, Grunst MW, Grover JR, Bess JW Jr, Lifson JD, Zwick MB, Tagare HD, Uchil PD, Mothes W. Nature. 2023 Nov; 2023 Nov 22. PMID: 37993716.
- Ice nucleation proteins self-assemble into large fibres to trigger freezing at near 0 °C.Hansen T, Lee JC, Reicher N, Ovadia G, Guo S, Guo W, Liu J, Braslavsky I, Rudich Y, Davies PL. bioRxiv. 2023 Oct 26; 2023 Oct 26. PMID: 37577566.
- Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella.Lian H, Park D, Chen M, Schueder F, Lara-Tejero M, Liu J, Galán JE. Nat Microbiol. 2023 Oct; 2023 Aug 28. PMID: 37640963.
- Immunogenicity and Pre-Clinical Efficacy of an OMV-Based SARS-CoV-2 Vaccine.Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Croia L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G. Vaccines (Basel). 2023 Sep 29; 2023 Sep 29. PMID: 37896949.
- Single-cell multiomic understanding of HIV-1 reservoir at epigenetic, transcriptional, and protein levels.Wong M, Wei Y, Ho YC. Curr Opin HIV AIDS. 2023 Sep 1; 2023 Jul 17. PMID: 37535039.
- Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments.Huang X, Torre I, Chiappi M, Yin Z, Vydyanath A, Cao S, Raschdorf O, Beeby M, Quigley B, de Tombe PP, Liu J, Morris EP, Luther PK. J Muscle Res Cell Motil. 2023 Sep; 2023 Apr 28. PMID: 37115473.
- Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.Leonhardt SA, Purdy MD, Grover JR, Yang Z, Poulos S, McIntire WE, Tatham EA, Erramilli SK, Nosol K, Lai KK, Ding S, Lu M, Uchil PD, Finzi A, Rein A, Kossiakoff AA, Mothes W, Yeager M. Nat Commun. 2023 Jul 20; 2023 Jul 20. PMID: 37474505.
- PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.Xu D, Jiang W, Wu L, Gaudet RG, Park ES, Su M, Cheppali SK, Cheemarla NR, Kumar P, Uchil PD, Grover JR, Foxman EF, Brown CM, Stansfeld PJ, Bewersdorf J, Mothes W, Karatekin E, Wilen CB, MacMicking JD. Nature. 2023 Jul; 2023 Jul 12. PMID: 37438530.
- Integration site-dependent HIV-1 promoter activity shapes host chromatin conformation.Collora JA, Ho YC. Genome Res. 2023 Jun; 2023 Jun 9. PMID: 37295842.
- A peek inside the 2023 Bacterial Locomotion and Signal Transduction (BLAST) conference.Hadjifrangiskou M, Liu J, Ottemann KM, Roujeinikova A. Trends Microbiol. 2023 Jun; 2023 Apr 29. PMID: 37127442.
- Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine.Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Lascio GD, Tamburini S, Caproni E, Croia L, Ravà M, Fumagalli V, Lucia PD, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G. Res Sq. 2023 May 25; 2023 May 25. PMID: 37292970.
- Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models.Lorenzo MM, Marín-López A, Chiem K, Jimenez-Cabello L, Ullah I, Utrilla-Trigo S, Calvo-Pinilla E, Lorenzo G, Moreno S, Ye C, Park JG, Matía A, Brun A, Sánchez-Puig JM, Nogales A, Mothes W, Uchil PD, Kumar P, Ortego J, Fikrig E, Martinez-Sobrido L, Blasco R. Vaccines (Basel). 2023 May 21; 2023 May 21. PMID: 37243110.
- Temsavir blocks the immunomodulatory activities of HIV-1 soluble gp120.Richard J, Prévost J, Bourassa C, Brassard N, Boutin M, Benlarbi M, Goyette G, Medjahed H, Gendron-Lepage G, Gaudette F, Chen HC, Tolbert WD, Smith AB 3rd, Pazgier M, Dubé M, Clark A, Mothes W, Kaufmann DE, Finzi A. Cell Chem Biol. 2023 May 18; 2023 Mar 22. PMID: 36958337.
- Infection leaves a genetic and functional mark on the gut population of a commensal bacterium.Tawk C, Lim B, Bencivenga-Barry NA, Lees HJ, Ramos RJF, Cross J, Goodman AL. Cell Host Microbe. 2023 May 10; 2023 Apr 28. PMID: 37119822.
- Cross-feeding in the gut microbiome: Ecology and mechanisms.Culp EJ, Goodman AL. Cell Host Microbe. 2023 Apr 12. PMID: 37054671.
- Bacteria require phase separation for fitness in the mammalian gut.Krypotou E, Townsend GE, Gao X, Tachiyama S, Liu J, Pokorzynski ND, Goodman AL, Groisman EA. Science. 2023 Mar 17; 2023 Mar 16. PMID: 36927025.
- The Coxiella burnetii effector EmcB is a deubiquitinase that inhibits RIG-I signaling.Duncan-Lowey J, Crabill E, Jarret A, Reed SCO, Roy CR. Proc Natl Acad Sci U S A. 2023 Mar 14; 2023 Mar 9. PMID: 36893270.
- Positive-strand RNA viruses-a Keystone Symposia report.Cable J, Denison MR, Kielian M, Jackson WT, Bartenschlager R, Ahola T, Mukhopadhyay S, Fremont DH, Kuhn RJ, Shannon A, Frazier MN, Yuen KY, Coyne CB, Wolthers KC, Ming GL, Guenther CS, Moshiri J, Best SM, Schoggins JW, Jurado KA, Ebel GD, Schäfer A, Ng LFP, Kikkert M, Sette A, Harris E, Wing PAC, Eggenberger J, Krishnamurthy SR, Mah MG, Meganck RM, Chung D, Maurer-Stroh S, Andino R, Korber B, Perlman S, Shi PY, Bárcena M, Aicher SM, Vu MN, Kenney DJ, Lindenbach BD, Nishida Y, Rénia L, Williams EP. Ann N Y Acad Sci. 2023 Mar; 2023 Jan 25. PMID: 36697369.
- Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection.Ganesan S, Alvarez NN, Steiner S, Fowler KM, Corona AK, Roy CR. mBio. 2023 Feb 28; 2023 Feb 2. PMID: 36728431.
- Anti-σ(28) Factor FlgM Regulates Flagellin Gene Expression and Flagellar Polarity of Treponema denticola.Kurniyati K, Chang Y, Guo W, Liu J, Malkowski MG, Li C. J Bacteriol. 2023 Feb 22; 2023 Jan 30. PMID: 36715541.
- Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.Chen Y, Prévost J, Ullah I, Romero H, Lisi V, Tolbert WD, Grover JR, Ding S, Gong SY, Beaudoin-Bussières G, Gasser R, Benlarbi M, Vézina D, Anand SP, Chatterjee D, Goyette G, Grunst MW, Yang Z, Bo Y, Zhou F, Béland K, Bai X, Zeher AR, Huang RK, Nguyen DN, Sherburn R, Wu D, Piszczek G, Paré B, Matthies D, Xia D, Richard J, Kumar P, Mothes W, Côté M, Uchil PD, Lavallée VP, Smith MA, Pazgier M, Haddad E, Finzi A. iScience. 2023 Jan 20; 2022 Dec 9. PMID: 36514310.
- The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice.Ullah I, Beaudoin-Bussières G, Symmes K, Cloutier M, Ducas E, Tauzin A, Laumaea A, Grunst MW, Dionne K, Richard J, Bégin P, Mothes W, Kumar P, Bazin R, Finzi A, Uchil PD. Cell Rep Med. 2023 Jan 17; 2022 Dec 29. PMID: 36584683.
- Gut colonization by Bacteroides requires translation by an EF-G paralog lacking GTPase activity.Han W, Peng BZ, Wang C, Townsend GE 2nd, Barry NA, Peske F, Goodman AL, Liu J, Rodnina MV, Groisman EA. EMBO J. 2023 Jan 16; 2022 Dec 6. PMID: 36472247.
2022
- Assembly and architecture of the type III secretion sorting platform.Soto JE, Galán JE, Lara-Tejero M. Proc Natl Acad Sci U S A. 2022 Dec 20; 2022 Dec 13. PMID: 36512499.
- Interferon opens up: HIV-induced inflammation reconfigures 3D chromatin conformation and affects where HIV integrates.Wei Y, Ho YC. Mol Cell. 2022 Dec 15. PMID: 36525953.
- Rewiring the logic board of IFN signaling.MacMicking JD. Sci Signal. 2022 Dec 13; 2022 Dec 13. PMID: 36512642.
- An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria.Gupta KR, Gwin CM, Rahlwes KC, Biegas KJ, Wang C, Park JH, Liu J, Swarts BM, Morita YS, Rego EH. Elife. 2022 Nov 8; 2022 Nov 8. PMID: 36346214.
- Cryo-EM structures of prefusion SIV envelope trimer.Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess JW Jr, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD. Nat Struct Mol Biol. 2022 Nov; 2022 Nov 7. PMID: 36344847.
- Developmental Transitions Coordinate Assembly of the Coxiella burnetii Dot/Icm Type IV Secretion System.Park D, Steiner S, Shao M, Roy CR, Liu J. Infect Immun. 2022 Oct 20; 2022 Oct 3. PMID: 36190257.
- A Tripartite Efflux System Affects Flagellum Stability in Helicobacter pylori.Gibson K, Chu JK, Zhu S, Nguyen D, Mrázek J, Liu J, Hoover TR. Int J Mol Sci. 2022 Oct 1; 2022 Oct 1. PMID: 36232924.
- Editorial: Biological rotary nanomotors.Manson MD, Nan B, Lele PP, Liu J, Duncan TM. Front Microbiol. 2022; 2022 Sep 21. PMID: 36212881.
- Identification and Characterization of the Alternative σ(28) Factor in Treponema denticola.Kurniyati K, Chang Y, Liu J, Li C. J Bacteriol. 2022 Sep 20; 2022 Aug 31. PMID: 36043861.
- Transcriptome of Epibiont Saccharibacteria Nanosynbacter lyticus Strain TM7x During the Establishment of Symbiosis.Hendrickson EL, Bor B, Kerns KA, Lamont EI, Chang Y, Liu J, Cen L, Schulte F, Hardt M, Shi W, He X, McLean JS. J Bacteriol. 2022 Sep 20; 2022 Aug 17. PMID: 35975994.
- Transcriptional and functional characterizations of multiple flagellin genes in spirochetes.Kurniyati K, Chang Y, Liu J, Li C. Mol Microbiol. 2022 Sep; 2022 Jul 18. PMID: 35776658.
- Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. Sci Adv. 2022 Jul 15; 2022 Jul 13. PMID: 35857504.
- VE607 stabilizes SARS-CoV-2 Spike in the "RBD-up" conformation and inhibits viral entry.Ding S, Ullah I, Gong SY, Grover JR, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Gaudette F, Richard J, Yang D, Smith AB 3rd, Pazgier M, Côté M, Abrams C, Kumar P, Mothes W, Uchil PD, Finzi A, Baron C. iScience. 2022 Jul 15; 2022 Jun 3. PMID: 35677392.
- Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen.Pedersen SF, Collora JA, Kim RN, Yang K, Razmi A, Catalano AA, Yeh YJ, Mounzer K, Tebas P, Montaner LJ, Ho YC. J Virol. 2022 Jul 13; 2022 Jun 22. PMID: 35730977.
- Increasing the resilience of plant immunity to a warming climate.Kim JH, Castroverde CDM, Huang S, Li C, Hilleary R, Seroka A, Sohrabi R, Medina-Yerena D, Huot B, Wang J, Nomura K, Marr SK, Wildermuth MC, Chen T, MacMicking JD, He SY. Nature. 2022 Jul; 2022 Jun 29. PMID: 35768511.
- Mycobacterial serine/threonine phosphatase PstP is phosphoregulated and localized to mediate control of cell wall metabolism.Shamma F, Rego EH, Boutte CC. Mol Microbiol. 2022 Jul; 2022 Jun 20. PMID: 35670057.
- Cell Wall Damage Reveals Spatial Flexibility in Peptidoglycan Synthesis and a Nonredundant Role for RodA in Mycobacteria.Melzer ES, Kado T, García-Heredia A, Gupta KR, Meniche X, Morita YS, Sassetti CM, Rego EH, Siegrist MS. J Bacteriol. 2022 Jun 21; 2022 May 11. PMID: 35543537.
- Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones.Collora JA, Liu R, Pinto-Santini D, Ravindra N, Ganoza C, Lama JR, Alfaro R, Chiarella J, Spudich S, Mounzer K, Tebas P, Montaner LJ, van Dijk D, Duerr A, Ho YC. Immunity. 2022 Jun 14; 2022 Mar 22. PMID: 35320704.
- The Bacterial Flagellar Motor: Insights Into Torque Generation, Rotational Switching, and Mechanosensing.Guo S, Liu J. Front Microbiol. 2022; 2022 May 30. PMID: 35711788.
- Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells.Chang SJ, Hsu YT, Chen Y, Lin YY, Lara-Tejero M, Galan JE. Elife. 2022 May 17; 2022 May 17. PMID: 35579416.
- Cancer Microbiology.DiMaio D, Emu B, Goodman AL, Mothes W, Justice A. J Natl Cancer Inst. 2022 May 9. PMID: 34850062.
- The In Vivo and In Vitro Architecture of the Hepatitis C Virus RNA Genome Uncovers Functional RNA Secondary and Tertiary Structures.Wan H, Adams RL, Lindenbach BD, Pyle AM. J Virol. 2022 Apr 27; 2022 Mar 30. PMID: 35353000.
- Gut Commensal Bacteroidetes Encode a Novel Class of Vitamin B(12)-Binding Proteins.Putnam EE, Abellon-Ruiz J, Killinger BJ, Rosnow JJ, Wexler AG, Folta-Stogniew E, Wright AT, van den Berg B, Goodman AL. mBio. 2022 Apr 26; 2022 Mar 1. PMID: 35227073.
- Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome.Wang F, Cvirkaite-Krupovic V, Vos M, Beltran LC, Kreutzberger MAB, Winter JM, Su Z, Liu J, Schouten S, Krupovic M, Egelman EH. Cell. 2022 Apr 14; 2022 Mar 23. PMID: 35325592.
- TCR-mimic bispecific antibodies to target the HIV-1 reservoir.Sengupta S, Board NL, Wu F, Moskovljevic M, Douglass J, Zhang J, Reinhold BR, Duke-Cohan J, Yu J, Reed MC, Tabdili Y, Azurmendi A, Fray EJ, Zhang H, Hsiue EH, Jenike K, Ho YC, Gabelli SB, Kinzler KW, Vogelstein B, Zhou S, Siliciano JD, Sadegh-Nasseri S, Reinherz EL, Siliciano RF. Proc Natl Acad Sci U S A. 2022 Apr 12; 2022 Apr 8. PMID: 35394875.
- Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2.Cale EM, Driscoll JI, Lee M, Gorman J, Zhou T, Lu M, Geng H, Lai YT, Chuang GY, Doria-Rose NA, Mothes W, Kwong PD, Mascola JR. J Biol Chem. 2022 Apr; 2022 Mar 10. PMID: 35283191.
- FliL ring enhances the function of periplasmic flagella.Guo S, Xu H, Chang Y, Motaleb MA, Liu J. Proc Natl Acad Sci U S A. 2022 Mar 15; 2022 Mar 7. PMID: 35254893.
- A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection.Beaudoin-Bussières G, Chen Y, Ullah I, Prévost J, Tolbert WD, Symmes K, Ding S, Benlarbi M, Gong SY, Tauzin A, Gasser R, Chatterjee D, Vézina D, Goyette G, Richard J, Zhou F, Stamatatos L, McGuire AT, Charest H, Roger M, Pozharski E, Kumar P, Mothes W, Uchil PD, Pazgier M, Finzi A. Cell Rep. 2022 Feb 15; 2022 Jan 25. PMID: 35123652.
- Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila.Macé K, Meir A, Lukoyanova N, Liu L, Chetrit D, Hospenthal MK, Roy CR, Waksman G. Mol Microbiol. 2022 Feb; 2021 Dec 6. PMID: 34816517.
- The flagellar motor protein FliL forms a scaffold of circumferentially positioned rings required for stator activation.Tachiyama S, Chan KL, Liu X, Hathroubi S, Peterson B, Khan MF, Ottemann KM, Liu J, Roujeinikova A. Proc Natl Acad Sci U S A. 2022 Jan 25. PMID: 35046042.
- The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist.Collora JA, Ho YC. Cell. 2022 Jan 20. PMID: 35063069.
- Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. Cell Rep. 2022 Jan 11; 2021 Dec 15. PMID: 34971573.
- Reinventing positive-strand RNA virus reverse genetics.Lindenbach BD. Adv Virus Res. 2022; 2022 Mar 29. PMID: 35840179.
2021
- Characterization of the Flagellar Collar Reveals Structural Plasticity Essential for Spirochete Motility.Chang Y, Xu H, Motaleb MA, Liu J. mBio. 2021 Dec 21; 2021 Nov 23. PMID: 34809456.
- A multidimensional HIV-1 persistence model for clonal expansion and viral rebound in vitro.Eshetu A, Ho YC. Cell Rep Methods. 2021 Dec 20; 2021 Dec 20. PMID: 35475216.
- Design and implementation of a cohort study of persons living with HIV infection who are initiating medication treatment for opioid use disorder to evaluate HIV-1 persistence.Schultheis A, Sanchez M, Pedersen S, Kyriakides T, Ho YC, Kluger Y, Springer SA. Contemp Clin Trials Commun. 2021 Dec; 2021 Nov 11. PMID: 34825103.
- Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. bioRxiv. 2021 Nov 24; 2021 Nov 24. PMID: 34845451.
- The Legionella pneumophila Effector RavY Contributes to a Replication-Permissive Vacuolar Environment during Infection.Liu L, Roy CR. Infect Immun. 2021 Nov 16; 2021 Sep 20. PMID: 34543123.
- Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome.Guo EZ, Galán JE. Proc Natl Acad Sci U S A. 2021 Nov 2. PMID: 34706941.
- Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira.Fule L, Halifa R, Fontana C, Sismeiro O, Legendre R, Varet H, Coppée JY, Murray GL, Adler B, Hendrixson DR, Buschiazzo A, Guo S, Liu J, Picardeau M. Mol Microbiol. 2021 Nov; 2021 Oct 30. PMID: 34657338.
- Salmonella Typhimurium and inflammation: a pathogen-centric affair.Galán JE. Nat Rev Microbiol. 2021 Nov; 2021 May 19. PMID: 34012042.
- Structural basis of bacterial flagellar motor rotation and switching.Chang Y, Carroll BL, Liu J. Trends Microbiol. 2021 Nov; 2021 Apr 14. PMID: 33865677.
- BB0259 Encompasses a Peptidoglycan Lytic Enzyme Function for Proper Assembly of Periplasmic Flagella in Borrelia burgdorferi.Xu H, Hu B, Flesher DA, Liu J, Motaleb MA. Front Microbiol. 2021; 2021 Oct 1. PMID: 34659138.
- Impact of temperature on the affinity of SARS-CoV-2 Spike glycoprotein for host ACE2.Prévost J, Richard J, Gasser R, Ding S, Fage C, Anand SP, Adam D, Gupta Vergara N, Tauzin A, Benlarbi M, Gong SY, Goyette G, Privé A, Moreira S, Charest H, Roger M, Mothes W, Pazgier M, Brochiero E, Boivin G, Abrams CF, Schön A, Finzi A. J Biol Chem. 2021 Oct; 2021 Aug 31. PMID: 34478710.
- The Clonal Expansion Dynamics of the HIV-1 Reservoir: Mechanisms of Integration Site-Dependent Proliferation and HIV-1 Persistence.Yeh YJ, Yang K, Razmi A, Ho YC. Viruses. 2021 Sep 17; 2021 Sep 17. PMID: 34578439.
- Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy.Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen CB, Dekaban GA, Dikeakos JD, Bruce EA, Kaufmann DE, Stamatatos L, McGuire AT, Richard J, Pazgier M, Bjorkman PJ, Mothes W, Finzi A, Kumar P, Uchil PD. Immunity. 2021 Sep 14; 2021 Aug 18. PMID: 34453881.
- A Common Pathway for Activation of Host-Targeting and Bacteria-Targeting Toxins in Human Intestinal Bacteria.Bao Y, Verdegaal AA, Anderson BW, Barry NA, He J, Gao X, Goodman AL. mBio. 2021 Aug 31; 2021 Aug 31. PMID: 34465018.
- Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.Zhang CH, Spasov KA, Reilly RA, Hollander K, Stone EA, Ippolito JA, Liosi ME, Deshmukh MG, Tirado-Rives J, Zhang S, Liang Z, Miller SJ, Isaacs F, Lindenbach BD, Anderson KS, Jorgensen WL. ACS Med Chem Lett. 2021 Aug 12; 2021 Jul 14. PMID: 34408808.
- Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern.Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. bioRxiv. 2021 Aug 3; 2021 Aug 3. PMID: 34373853.
- A human apolipoprotein L with detergent-like activity kills intracellular pathogens.Gaudet RG, Zhu S, Halder A, Kim BH, Bradfield CJ, Huang S, Xu D, Mamiñska A, Nguyen TN, Lazarou M, Karatekin E, Gupta K, MacMicking JD. Science. 2021 Jul 16. PMID: 34437126.
- A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.Tauzin A, Nayrac M, Benlarbi M, Gong SY, Gasser R, Beaudoin-Bussières G, Brassard N, Laumaea A, Vézina D, Prévost J, Anand SP, Bourassa C, Gendron-Lepage G, Medjahed H, Goyette G, Niessl J, Tastet O, Gokool L, Morrisseau C, Arlotto P, Stamatatos L, McGuire AT, Larochelle C, Uchil P, Lu M, Mothes W, De Serres G, Moreira S, Roger M, Richard J, Martel-Laferrière V, Duerr R, Tremblay C, Kaufmann DE, Finzi A. Cell Host Microbe. 2021 Jul 14; 2021 Jun 4. PMID: 34133950.
- Interconnecting solvent quality, transcription, and chromosome folding in Escherichia coli.Xiang Y, Surovtsev IV, Chang Y, Govers SK, Parry BR, Liu J, Jacobs-Wagner C. Cell. 2021 Jul 8; 2021 Jun 28. PMID: 34186018.