Microbiome Research at Yale
The microbiota (the collection of bacteria, archaea, eukaryotes, and viruses that live in or on a host organism) impacts many aspects of human and environmental health. Labs at Yale University explore these relationships using a wide range of systems and tools.
These groups belong to many departments and interact through research seminars, graduate student advising, and extensive collaboration.
To be added to this page, please contact andrew.goodman@yale.edu
Department of Chemistry
Department of Microbial Pathogenesis
Chemical Biology Institute
The Crawford group decodes orphan bacterial biosynthetic gene clusters in bacteria-insect and bacteria-human associations.
Department of Infectious Diseases
Department of Microbial Pathogenesis
We study how the microbiota of ticks and mosquitoes influences the transmission of arthropod-borne diseases.
Department of Immunobiology
The Flavell lab studies the relationship between the microbiota and the immune system, particularly in the context of human diseases such as IBD, metabolic syndrome and cancer and their mouse models.
Department of Microbial Pathogenesis
Mechanisms of enteric pathogen restriction by the gut microbiota.
Department of Digestive Diseases
Microbiome research in experimental cirrhosis to identify measures to decrease bacterial translocation, a mechanism that leads to systemic inflammation and decompensation in patients with cirrhosis.
Department of Microbial Pathogenesis
Cooperation and competition in the human gut microbiome; role of the gut microbiota in drug metabolism and function.
Department of Microbial Pathogenesis
Our laboratory investigates gene control in Bacteroides thetaiotaomicron, a dominant member of the mammalian gut microbiota.
Department of Neurology
Our lab is investigating the interplay between human diet, microbiome, genetics, and immune reponses in inflammatory disease.
Department of Molecular, Cellular, and Developmental Biology
My lab applies chemical biology to the discovery of enzymes and other proteins whose biochemical activity shapes host-microbe dynamics in the context of gastrointestinal infections and the gut microbiota.
Department of Immunobiology
My lab is interested in looking at the effect of the microbiome on responses to biologics and in understanding how the microbiome regulates immune tolerance.
Department of Molecular, Cellular, and Developmental Biology
Systems Biology Institute
Applying synthetic biology technologies to engineer clinical and ecological microbiomes.
Department of Immunobiology
The Iwasaki laboratory studies the role of microbiome and virome on immunity and inflammatory diseases. Our research showed that signals from the microbiome help optimize the immune response in the respiratory tract against influenza virus infection.
Department of Environmental Health
Understanding the role of microbial metabolites in human disease.
Department of Microbial Pathogenesis, Department of Infectious Diseases
Acquisition and maturation of the gut and airway microbiomes in infants with Cystic Fibrosis.
Department of Microbial Pathogenesis
We are developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells, in order to gain molecular insights into fundamental biochemical processes.
Department of Molecular Biophysics and Biochemistry
Provenance and authentication of works of art and other forms of cultural heritage.
Department of Immunobiology
The Palm lab is focused on illuminating the fundamental principles that govern immune-microbiota interactions in human health and disease.
Department of Epidemiology
The Pettigrew research lab conducts clinical epidemiologic studies of the respiratory and gastrointestinal microbiota in order to facilitate progress towards the goal of manipulating the microbiota for control of antibiotic resistance and transmission of multi-drug resistant organisms.
Department of Ecology and Evolutionary Biology
Our lab studies the microbial ecology of mosquito oviposition.
Department of Ecology and Evolutionary Biology
Our lab studies the evolution of public goods based microbial communities, using a combination of mathematical modeling and experiments in vitro.
Department of Ecology and Evolutionary Biology
The Turner Lab is interested in the role of bacteriophages in the ecology and evolution of microbiomes, especially phage therapy approaches to targeting bacterial pathogens in/on the human body and whether such treatment affects community composition of resident phages and non-target bacteria inhabiting the microbiome.
Department of Endocrinology
We study the role of the microbiome in the pathogenesis of type 1 diabetes and obesity, focusing on their interaction with immune cells in mouse models and humans.
Department of Molecular, Cellular, and Developmental Biology
Laboratory of Epidemiology and Public Health
Development and application of statistical methods for the analysis of microbiome data.