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Barbara Kazmierczak, MD, PhD

Gustavus and Louise Pfeiffer Research Foundation M.D.-Ph.D. Program Director and Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis; Professor, Microbial Pathogenesis; Director, MD-PhD Program, Yale University

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Barbara Kazmierczak, MD, PhD

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Dr. Kazmierczak received her PhD from Rockefeller University (1993) and her MD from Cornell University Medical College (1994), both in New York City. She completed an Internal Medicine residency and Infectious Diseases fellowship training at the University of California, San Francisco, and joined the Yale faculty in 2001. She is currently a Professor of Medicine and Microbial Pathogenesis, and Director of the MD-PhD program at Yale.

Dr. Kazmierczak's research program is broadly focused on bacterial and host factors that allow opportunistic infections to occur. Using Pseudomonas aeruginosa as a clinically relevant model, her lab addresses fundamental questions of how cell-envelope spanning bacterial machines - the Type 3 secretion system, Type 4 pili and polar flagellum - are assembled, regulated, and used during infection. She has also identified host responses directed at components of these virulence associated structures, in particular those mediated by the NLRC4 inflammasome. Inflammatory responses to bacteria are also a focus of her work on microbiome-host interactions in infants with Cystic Fibrosis, where her lab has used longitudinal data acquired over five years from cohorts of patients and controls to understand gut microbiome composition and the inflammatory and metabolic responses at this site.

Dr. Kazmierczak has been recognized as a Burroughs-Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases (2007), a Donaghue Investigator (2002), and a Hellman Family Fellow (2002). She is a Fellow of the Infectious Diseases Society of America and an elected member of the American Society for Clinical Investigation and the American Academy for Microbiology.

Education & Training

  • Assistant Adjunct Professor
    University of California, San Francisco (2001)
  • Fellow
    University of California, San Francisco (1999)
  • Resident
    University of California, San Francisco (1996)
  • Intern
    University of California, San Francisco (1995)
  • MD
    Cornell University Medical College (1994)
  • PhD
    Rockefeller University (1993)
  • MS
    University of Chicago (1986)
  • BA
    University of Chicago (1986)


  • Innate immune responses to bacterial infection
    Berlin, Berlin, Germany 2010
    Visiting Researcher

Honors & Recognition

AwardAwarding OrganizationDate
Elected Member, AAMAmerican Academy for Microbiology2019
Distinguished LecturerAmerican Society for Microbiology2018
Elected Member, ASCIAmerican Society for Clinical Investigation2014
Visiting Faculty Research GrantDeutscher Akademischer Austausch Dienst (DAAD)2010
Elected MemberPolish Institute of Arts and Sciences in America2009
Fellow, IDSAInfectious Diseases Society of America2008
Investigator in Pathogenesis of Infectious DiseasesBurroughs Wellcome Fund2007
Investigator AwardPatrick and Catherine Weldon Donaghue Medical Research Foundation2003

Professional Service

MD-PhD Steering Committee, GREAT Group, AAMCMember2017 - Present
Yale UniversityAssociate Director for Basic Research, MD-PhD Program2010 - 2014
IDSAAnnual Meeting Planning Committee2009 - 2012
Director of Admissions, Microbiology Program, Yale UniversityMember2004 - 2007
Yale UniversityMD/PhD Faculty Committee2004 - Present

Departments & Organizations