Stuart Zarich, MD
About
Research
Publications
2025
Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-cause mortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervalsTranscatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis
Ahmed A, Kaddoura R, Aggarwal A, Zinyandu T, Webber F, Davila C, Zarich S. Transcatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis. Catheterization And Cardiovascular Interventions 2025, 105: 754-760. PMID: 39748537, DOI: 10.1002/ccd.31367.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementAortic valve replacementHypertrophic cardiomyopathyAortic stenosisRenal impairmentValve replacementAortic dissectionVascular complicationsCardiogenic shockOdds ratioTranscatheter aortic valve replacement outcomesSevere aortic stenosisPermanent pacemaker implantationComplete heart blockAssociated with higher ratesObservational cohort studyGold standard managementConfidence intervalsRandom-effects modelSignificantly higher occurrenceSurgical riskPacemaker implantationHeart blockSurgical intervention
2024
A Rare Case of Acute Bacterial Native Valve Endocarditis Caused by Streptococcus thoraltensis
Abid S, Stolear A, Dulgher M, Sethi S, Zarich S. A Rare Case of Acute Bacterial Native Valve Endocarditis Caused by Streptococcus thoraltensis. Cureus 2024, 16: e70934. PMID: 39502956, PMCID: PMC11537169, DOI: 10.7759/cureus.70934.Peer-Reviewed Original ResearchNative valve endocarditisIntravenous drug useValve endocarditisRare caseHistory of intravenous drug useLost to follow-upTricuspid valve vegetationPartial clinical improvementDrug useIntravenous ceftriaxoneValve vegetationsBlood culturesChest painPulmonary embolismClinical improvementProductive coughRare pathogenAtrial flutterFollow-upClinical evaluationPatient historyExposure to animalsEndocarditisHuman pathogensPatientsPulmonary embolism with thrombus in transit across a patent foramen ovale
Iyengar S, Stolear A, Dulgher M, Ahmed A, Shkolnik E, Zarich S. Pulmonary embolism with thrombus in transit across a patent foramen ovale. Oxford Medical Case Reports 2024, 2024: omae091. PMID: 39184868, PMCID: PMC11343825, DOI: 10.1093/omcr/omae091.Peer-Reviewed Original ResearchPatent foramen ovalePatent foramen ovale closureImpending paradoxical embolismPulmonary embolismForamen ovaleCritical left anterior descending coronary artery stenosisObstructive sleep apneaCoronary artery bypass graftingOptimal treatment strategySaddle pulmonary embolusAbsence of standard guidelinesDeep vein thrombosisArtery bypass graftingLife-threatening conditionCoronary artery stenosisSleep apneaTransesophageal echocardiogramPulmonary emboliSurgical thrombectomyVein thrombosisDiagnostic challengeSurgical interventionRight atriumThrombolytic therapyBypass graftingIn-Hospital Outcomes and 30-Day Readmission Rate After Transcatheter and Surgical Aortic Valve Replacement in Liver Cirrhosis: A Contemporary Propensity-Matched Analysis
Aggarwal A, Jang S, Vardhan S, Webber F, Alam M, Vardhan M, Lancaster G, Ahmad Y, Vora A, Zarich S, Inglessis-Azuaje I, Elmariah S, Forrest J, Davila C. In-Hospital Outcomes and 30-Day Readmission Rate After Transcatheter and Surgical Aortic Valve Replacement in Liver Cirrhosis: A Contemporary Propensity-Matched Analysis. Structural Heart 2024, 8: 100327. PMID: 39670045, PMCID: PMC11632700, DOI: 10.1016/j.shj.2024.100327.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementTranscatheter aortic valve replacement groupValve replacementIn-hospital mortalityHepatorenal syndromeReadmission ratesCardiogenic shockLiver cirrhosisVascular complicationsIn-hospitalOutcomes of transcatheter aortic valve replacementSurgical risk prediction modelsSurgical aortic valve replacement groupAssociated with significantly lower ratesRates of in-hospital mortalityLimited contemporary dataIn-hospital outcomesSignificantly lower ratesNationwide Readmissions DatabaseCardiac surgeryPeriprocedural morbidityTherapeutic optionsClinical characteristicsE-2 | Prevalence and Clinical Correlates of Obstructive Sleep Apnea on In-hospital Outcomes following Transcatheter Aortic Valve Replacement: Results from National Inpatient Sample Database 2016-2020
Aggarwal A, Garcia A, Vasquez M, Vardhan S, Ahmed A, Vardhan M, Batlle J, Zarich S, Davila C. E-2 | Prevalence and Clinical Correlates of Obstructive Sleep Apnea on In-hospital Outcomes following Transcatheter Aortic Valve Replacement: Results from National Inpatient Sample Database 2016-2020. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 101758. DOI: 10.1016/j.jscai.2024.101758.Peer-Reviewed Original ResearchCatecholaminergic Polymorphic Ventricular Tachycardia: Clinical Characteristics, Diagnostic Evaluation and Therapeutic Strategies
Aggarwal A, Stolear A, Alam M, Vardhan S, Dulgher M, Jang S, Zarich S. Catecholaminergic Polymorphic Ventricular Tachycardia: Clinical Characteristics, Diagnostic Evaluation and Therapeutic Strategies. Journal Of Clinical Medicine 2024, 13: 1781. PMID: 38542006, PMCID: PMC10971616, DOI: 10.3390/jcm13061781.Peer-Reviewed Original ResearchCatecholaminergic polymorphic ventricular tachycardiaLeft cardiac sympathetic denervationTraditional first-line treatmentAbsence of structural heart diseaseCalsequestrin 2 geneMyocyte sarcoplasmic reticulumRate of arrhythmic eventsCardiac ryanodine receptorCardiac sympathetic denervationPolymorphic ventricular arrhythmiasFirst-line treatmentPolymorphic ventricular tachycardiaStructural heart diseaseB-blocker therapySudden cardiac deathPotential new therapiesExercise stress testImplantable cardioverter-defibrillatorHereditary arrhythmia syndromesArrhythmia syndromesRyanodine receptorSarcoplasmic reticulumModerate exercise trainingSympathetic denervationArrhythmic events
2023
Permanent Complete Heart Block: A Rare Complication of Influenza Infection
Badheeb M, Zarich S, Fara F, Alam M. Permanent Complete Heart Block: A Rare Complication of Influenza Infection. Cureus 2023, 15: e51166. PMID: 38283436, PMCID: PMC10813590, DOI: 10.7759/cureus.51166.Peer-Reviewed Original ResearchHeart blockInfluenza infectionComplication of influenza infectionPermanent complete heart blockPermanent dual-chamber pacemakerInfluenza A infectionJunctional escape rhythmTransient atrioventricular blockComplete heart blockDual-chamber pacemakerFlu-like symptomsPolymerase chain reaction testCardiac comorbiditiesInfluenza virusRare complicationAtrioventricular blockMyocardial inflammationEscape rhythmTemporary pacemakerCardiovascular complicationsSelf-resolvingViral illnessCardiology clinicFollow-upViral infection