Ryland Mortlock
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About
Biography
Ryland is a 4th year MD-PhD student pursuing his PhD in Genetics in the lab of Keith Choate, MD, PhD. His research focuses on applying animal models, spatial transcriptomics, and three-dimensional cell culture systems to study genetic skin diseases, specifically exploring how barrier dysfunction and cellular interactions contribute to inflammation in epidermal differentiation disorders. Prior to coming to Yale, Ryland graduated in 2019 from the University of Southern California with a degree in Chemical Engineering and completed a two-year Postbaccalaureate Research Fellowship at the National Institutes of Health.
Education & Training
- Postbaccalaureate Research Fellowship
- National Heart Lung Blood Institute, National Institutes of Health (2021)
- BS
- University of Southern California, Viterbi School of Engineering, Chemical Engineering (Biochemical Emphasis) (2019)
Research
Overview
Medical Research Interests
Biomedical Engineering; Data Science; Dermatology; Genetics; Genomics; Hematology; Nanotechnology; Systems Biology
ORCID
0000-0001-9666-4394
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ryland Mortlock's published research.
Publications Timeline
A big-picture view of Ryland Mortlock's research output by year.
Research Interests
Research topics Ryland Mortlock is interested in exploring.
Jeffrey Cohen, MD
Jonathan Leventhal, MD
Kelly Olino, MD, FACS
W. Mark Saltzman, PhD
Anthony Tanella, MD, BS
Barbara Burtness, MD
16Publications
71Citations
Publications
Featured Publications
Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling
Mortlock RD, Georgia SK, Finley SD. Dynamic Regulation of JAK-STAT Signaling Through the Prolactin Receptor Predicted by Computational Modeling. Cellular And Molecular Bioengineering 2020, 14: 15-30. PMID: 33633812, PMCID: PMC7878662, DOI: 10.1007/s12195-020-00647-8.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBeta-cell massBeta cellsInsulin-producing beta cellsReceptor internalizationContext of pregnancyPrimary beta cellsJAK-STATPancreatic beta cellsBeta cell expansionBeta-cell survivalSTAT5 activationProlactin receptor signalingINS-1 cellsGestational diabetesInsulin resistanceReceptor upregulationGlucose homeostasisBiphasic responseThe spectrum of cutaneous immune-related adverse events in patients with skin of color
Belzer A, Mortlock R, Olamiju B, Olino K, Cohen J, Leventhal J. The spectrum of cutaneous immune-related adverse events in patients with skin of color. Journal Of The American Academy Of Dermatology 2022, 88: 1156-1158. PMID: 36470309, PMCID: PMC10838520, DOI: 10.1016/j.jaad.2022.11.051.Peer-Reviewed Original ResearchCitationsThe effect of baseline eczema or psoriasis on the morphology of cutaneous immune-related adverse events due to immune checkpoint inhibitor therapy
Belzer A, Mortlock R, Pach J, Cohen J, Leventhal J. The effect of baseline eczema or psoriasis on the morphology of cutaneous immune-related adverse events due to immune checkpoint inhibitor therapy. Journal Of The American Academy Of Dermatology 2023, 88: 1198-1200. PMID: 36634749, PMCID: PMC10121758, DOI: 10.1016/j.jaad.2023.01.002.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsAssessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology
Mortlock R, Ma E, Cohen J, Damsky W. Assessment of Treatment-Relevant Immune Biomarkers in Psoriasis and Atopic Dermatitis: Toward Personalized Medicine in Dermatology. Journal Of Investigative Dermatology 2023, 143: 1412-1422. PMID: 37341663, PMCID: PMC10830170, DOI: 10.1016/j.jid.2023.04.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsAtopic dermatitisSkin diseasesInflammatory skin diseaseInflammatory skin conditionImmunologic biomarkersImmune biomarkersPersonalized medicineInflammatory dermatosesImmunologic approachesTherapy selectionSkin conditionsSingle-cell RNA sequencingMolecular profilingBiomarkersTissue stainingPsoriasisDermatitisDiseaseDermatologyRNA sequencingMedicineCurettageDermatosesTherapyPersonalized classificationInterrogation of clonal tracking data using barcodetrackR
Espinoza D, Mortlock R, Koelle S, Wu C, Dunbar C. Interrogation of clonal tracking data using barcodetrackR. Nature Computational Science 2021, 1: 280-289. PMID: 37621673, PMCID: PMC10449013, DOI: 10.1038/s43588-021-00057-4.Peer-Reviewed Original ResearchCitationsAltmetricConceptsProgenitor cellsClonal tracking studiesProgenitor cell outputContext of genesHSPC transplantCellular compartmentsCellular outputStandardized analytical frameworkLineage relationshipsHematopoietic stemClonal dynamicsHSPC gene therapyLineage reconstitutionR packageVector genotoxicityCellsShiny appTumor cellsClonal patternGene therapyTracking dataDiverse toolsGenesQuantitative insightsValuable insights
2024
295 Polymeric nanoparticles for in utero gene delivery in non-human primates
Piotrowski-Daspit A, Lynn A, Eaton D, Bracaglia L, Mortlock R, Tarantal A, Glazer P, Saltzman W. 295 Polymeric nanoparticles for in utero gene delivery in non-human primates. Journal Of Cystic Fibrosis 2024, 23: s157. DOI: 10.1016/s1569-1993(24)01135-4.Peer-Reviewed Original ResearchEnhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-lifeImpact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Lee B, Gin A, Wu C, Singh K, Grice M, Mortlock R, Abraham D, Fan X, Zhou Y, AlJanahi A, Choi U, DeRavin S, Shin T, Hong S, Dunbar C. Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques. Cell Stem Cell 2024, 31: 788. PMID: 38599215, PMCID: PMC11114628, DOI: 10.1016/j.stem.2024.04.005.Peer-Reviewed Original ResearchCitationsAltmetricImpact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Lee B, Gin A, Wu C, Singh K, Grice M, Mortlock R, Abraham D, Fan X, Zhou Y, AlJanahi A, Choi U, DeRavin S, Shin T, Hong S, Dunbar C. Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques. Cell Stem Cell 2024, 31: 455-466.e4. PMID: 38508195, PMCID: PMC10997443, DOI: 10.1016/j.stem.2024.02.010.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLentiviral vectorsRhesus macaquesGFP-expressing lentiviral vectorsClonal dynamicsLong-term engrafting hematopoietic stem cellsLong-term engraftmentHematopoietic stem cellsAutologous transplantation modelClinically relevant differencesLT-HSCLT-HSCsCells long-termTransplantation modelLentiviral transductionP53 inhibitionAnimal modelsStem cellsGenetic modification approachesRelevant differencesClonalityHSCCellsMacaquesEngraftmentCD33How Efforts to Understand Somatic Mosaicism Will Impact Dermatology
Mortlock R, Choate K. How Efforts to Understand Somatic Mosaicism Will Impact Dermatology. Journal Of Investigative Dermatology 2024, 144: 453-455. PMID: 38395493, PMCID: PMC11009867, DOI: 10.1016/j.jid.2023.10.007.Peer-Reviewed Original ResearchAltmetricMeSH Keywords
Academic Achievements & Community Involvement
activity Yale Journal of Biology and Medicine
Journal ServiceEditorial Board MemberDetails2019 - Present
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