John Stendahl, MD, PhD
Cards
About
Research
Publications
2024
Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging
Jeng G, Chen P, Hsieh M, Liu Z, Langdon J, Ahn S, Staib L, Stendahl J, Thorn S, Sinusas A, Duncan J, O'Donnell M. Coordinate-Independent 3-D Ultrasound Principal Stretch and Direction Imaging. IEEE Transactions On Biomedical Engineering 2024, PP: 1-12. PMID: 38941195, DOI: 10.1109/tbme.2024.3420220.Peer-Reviewed Original ResearchPrincipal stretchesAxial displacement componentsSpeckle tracking methodSpeckle tracking approachTracking methodRobust filterDisplacement componentsTissue incompressibilityDisplacement estimationStrain componentsDisplacement gradientsStrain informationLocalized diseased regionStrain imagingLagrangian strainLeast-squares methodTracking approachTracking frameworkCoordinate systemCardiac coordinate systemProbe orientationFilterHigher spatial resolutionCardiac datasetsEnhanced accuracyPrototype catheter-based device for real time dual-isotope myocardial mapping
Stendahl J, Vermillion B, Daghighian F, Sinusas A. Prototype catheter-based device for real time dual-isotope myocardial mapping. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.049. DOI: 10.1093/ehjci/jeae142.049.Peer-Reviewed Original ResearchMulti-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography
Ta K, Ahn S, Thorn S, Stendahl J, Zhang X, Langdon J, Staib L, Sinusas A, Duncan J. Multi-Task Learning for Motion Analysis and Segmentation in 3D Echocardiography. IEEE Transactions On Medical Imaging 2024, 43: 2010-2020. PMID: 38231820, DOI: 10.1109/tmi.2024.3355383.Peer-Reviewed Original ResearchMulti-task learning networkCross-stitch unitsComposite loss functionAccurate motion estimationTask-specific networksMotion estimationSegmentation masksLearning networkLoss functionSegmentation stepEchocardiography datasetNetworkMotion displacementMotion analysisMultiple time framesTaskAnalysis pipelineSegmentsStrain measurementsDatasetRepresentationLong-Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER-OLE Study.
Masri A, Lester S, Stendahl J, Hegde S, Sehnert A, Balaratnam G, Shah A, Fox S, Wang A. Long-Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER-OLE Study. Journal Of The American Heart Association 2024, 13: e030607. PMID: 38591260, DOI: 10.1161/jaha.123.030607.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathyKansas City Cardiomyopathy Questionnaire–Overall Summary scoreSymptomatic obstructive hypertrophic cardiomyopathyOutflow tract gradientHypertrophic cardiomyopathyNew York Heart Association class improvementLeft ventricular outflow tract gradientTreatment-emergent adverse eventsSerum NT-proBNP levelsLeft ventricular ejection fractionEffect of mavacamtenIndividual dose titrationNT-proBNP levelsVentricular ejection fractionSerum NT-proBNPSummary scoreLong-term safetyLonger-term treatmentDose titrationEjection fractionNT-proBNPB-blockersReduced doseAdverse eventsInterim resultsPREDICTORS OF ADVERSE LONG-TERM OUTCOME AFTER SEPTAL REDUCTION THERAPIES IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY : INSIGHTS FROM THE SHARE REGISTRY
Maurizi N, Antiochos P, Owens A, Lakdawala N, Saberi S, Russell M, Lin K, De Feria Alsina A, Reza N, Stendahl J, Abrams D, Semsarian C, Lampert R, Parikh V, Wheeler M, Ashley E, Michels M, Rossano J, Ryan T, Ingles J, Ware J, Ho C, Helms A, Day S, Olivotto I. PREDICTORS OF ADVERSE LONG-TERM OUTCOME AFTER SEPTAL REDUCTION THERAPIES IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY : INSIGHTS FROM THE SHARE REGISTRY. Journal Of The American College Of Cardiology 2024, 83: 353. DOI: 10.1016/s0735-1097(24)02343-x.Peer-Reviewed Original ResearchContractile phenotypes of engineered heart tissues derived from hypertrophic cardiomyopathy patients lacking sarcomeric mutations
Rasheed Y, Young S, Halder S, Li X, Stendahl J, Campbell S. Contractile phenotypes of engineered heart tissues derived from hypertrophic cardiomyopathy patients lacking sarcomeric mutations. Biophysical Journal 2024, 123: 388a. DOI: 10.1016/j.bpj.2023.11.2357.Peer-Reviewed Original Research
2023
Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress
Stendahl J, Liu Z, Boutagy N, Parajuli N, Lu A, Alkhalil I, Lin B, Duncan J, Sinusas A. Multiaxial pressure-strain analysis of regional myocardial work in the setting of graded coronary stenoses and dobutamine stress. AJP Heart And Circulatory Physiology 2023, 325: h492-h509. PMID: 37417870, PMCID: PMC10538990, DOI: 10.1152/ajpheart.00735.2022.Peer-Reviewed Original ResearchConceptsLow-dose dobutaminePressure-strain loopsCoronary stenosisMyocardial workRegional myocardial workPressure-strain analysisDobutamine stressBlood flowLow-dose dobutamine stressInvasive hemodynamic monitoringMid-left anteriorLow cardiac outputRegional myocardial blood flowCoronary blood flowIschemic heart diseasePresence of ischemiaMyocardial work indexModerate coronary stenosisMyocardial blood flowOpen-chest modelEjection of bloodInotropic supportPressure-strain relationshipHemodynamic monitoringCardiac outputLeft Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry
Alaiwi S, Roston T, Marstrand P, Claggett B, Parikh V, Helms A, Ingles J, Lampert R, Lakdawala N, Michels M, Owens A, Rossano J, Saberi S, Abrams D, Ashley E, Semsarian C, Stendahl J, Ware J, Miller E, Ryan T, Russell M, Day S, Olivotto I, Vissing C, Ho C. Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry. Circulation 2023, 148: 394-404. PMID: 37226762, PMCID: PMC10373850, DOI: 10.1161/circulationaha.122.062517.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic dysfunctionHypertrophic cardiomyopathyMedian ageHCM diagnosisVentricular assist device implantationCox proportional hazards modelComposite of deathVentricular systolic dysfunctionAssist device implantationVentricular ejection fractionProportional hazards modelCardiac transplantationSystolic dysfunctionEjection fractionHCM cohortPediatric cohortDevice implantationPoor outcomeSubsequent prognosisEchocardiographic reportsHazards modelPatientsAdult cohortPrognosisCohortSegmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network
Xie H, Liu Z, Shi L, Greco K, Chen X, Zhou B, Feher A, Stendahl J, Boutagy N, Kyriakides T, Wang G, Sinusas A, Liu C. Segmentation-Free PVC for Cardiac SPECT Using a Densely-Connected Multi-Dimensional Dynamic Network. IEEE Transactions On Medical Imaging 2023, 42: 1325-1336. PMID: 36459599, PMCID: PMC10204821, DOI: 10.1109/tmi.2022.3226604.Peer-Reviewed Original ResearchRadiotracers to address unmet clinical needs in cardiovascular imaging, part 2: inflammation, fibrosis, thrombosis, calcification, and amyloidosis imaging
Stendahl J, Kwan J, Pucar D, Sadeghi M. Radiotracers to address unmet clinical needs in cardiovascular imaging, part 2: inflammation, fibrosis, thrombosis, calcification, and amyloidosis imaging. Chinese Journal Of Nuclear Medicine And Molecular Imaging 2023, 43: 187-192. DOI: 10.3760/cma.j.cn321828-20221103-00333.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Academic Achievements and Community Involvement
Clinical Care
Overview
John Stendahl, MD, PhD, specializes in cardiovascular imaging and the diagnosis and management of inherited and infiltrative cardiomyopathies. He provides a patient-centered approach to care that is based on the latest scientific findings and diagnostics, and often involves genetic analysis and various types of advanced cardiac imaging.
Dr. Stendahl treats a variety of complex conditions, including hypertrophic, dilated, and arrhythmogenic cardiomyopathies, as well as cardiac amyloid. He performs and interprets various cardiovascular imaging studies, including cardiovascular SPECT, PET, and CT scans. His work includes stress testing and coronary CT for the diagnosis and treatment of coronary artery disease, as well as the latest molecular imaging techniques to evaluate various forms of cardiomyopathy.
In addition to caring for patients, Dr. Stendahl performs clinical and translational research pertaining to hypertrophic cardiomyopathy, heart failure, cardiac transplantation, cardiac devices, and cardiovascular imaging. This includes clinical trials of the latest medications to treat cardiomyopathies, as well as translational work focused on development and discovery.
Clinical Specialties
Cardiovascular Medicine
Fact Sheets
Hypertrophic Cardiomyopathy
Learn More on Yale MedicineCT Scan for Coronary Artery Disease
Learn More on Yale MedicineChronic Total Occlusion (CTO)
Learn More on Yale MedicineCardiomyopathies
Learn More on Yale Medicine
Board Certifications
Nuclear Cardiology
- Certification Organization
- Certification Board of Nuclear Cardiology
- Original Certification Date
- 2020
Yale Medicine News
Links & Media
News
- January 16, 2024
Yale's Cardiac Imaging Center Revolutionizes Translational Research
- May 17, 2023
Feher selected for ASNC leadership development program
- April 24, 2023Source: HealthCentral
Top HCM Fears and How to Conquer Them
- February 01, 2023
2023 American College of Cardiology late-breaking clinical trials and abstracts from Yale