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2023 American College of Cardiology late-breaking clinical trials and abstracts from Yale

February 01, 2023
by Elisabeth Reitman

Groundbreaking clinical research will be presented at the Ernest N. Morial Convention Center in New Orleans, LA, March 4 – 6, 2023.

Upcoming presentations from Yale Cardiovascular Medicine faculty and trainees at the American College of Cardiology (ACC) Annual Scientific Session in New Orleans, LA, March 4 – 6, 2023. The annual meeting brings together world-renowned clinicians and scholars.

Late-Breaking Clinical Trials

Session 405-14

Session 410-08

Mar. 4, 2023

610 - Dead, Alive or Somewhere in Between: Viability/Ischemia Testing Still Useful?
The role of multimodality imaging for guiding management in patients with ischemic cardiomyopathy continues to be a subject of ongoing debate. This session will highlight clinical challenges and synthesize the evolving role of multimodality imaging in the management of these patients
Eric J. Velazquez

622-14: Athlete with an ICD: When to Worry, How to Manage
This session will address controversies in management of athletes with arrhythmias, in a case-based format.

Rachel J. Lampert

623 - It’s All The Rage: Hot Topics in HFpEF
This session reviews new information to understand, diagnose and manage people with HFpEF. The session ends with clinical vignettes (with audience response) to test the application of this information. There will be ample opportunities for audience response and panel discussion.

Jeffrey M. Testani

640 - Efficient Value-Based Cardiovascular MRI: Joint Symposium of the Society for Cardiovascular Magnetic Resonance and the American College of Cardiology
This session will inform the audience on recent developments in fast cardiovascular MRI and how efficient CMR impacts clinical value-based cardiovascular practice today. The session includes health economic and CV team perspectives, a technical presentation of the methodology employed for rapid imaging, practical experience, and a panel discussion.

Lauren Anne Baldassarre

1119-028: Sex Differences Among Older Adults Undergoing Percutaneous Coronary Intervention For Stable Ischemic Heart Disease
Sumeet Kadian, Jonathan Hanna, Mannat Kadian, Ahmed Abdullah, Michael Nanna

1126-002: Association Of Rb-82 Pet Derived Regional Myocardial Blood Flow To Severity Of Angiographic Coronary Artery Stenosis In Patients Presenting With Acute Chest Pain 
Jiun-Ruey Hu, Camila Trejo-Paredes, Samit Shah, Yi-Hwa Liu, Kim G. E. Smolderen, Carlos Mena Hurtado, Albert J. Sinusas, Edward James Miller, Cesia Maria Gallegos Kattan

1136-004: Sex Differences In The Hypertensive Response To Exercise Phenomenon
Aishwarya Nene, Olayinka J. Agboola, Jeph Herrin, Oyere Onuma, Yuan Lu, Edward James Miller, Erica Sarah Spatz, Judith Lynne Meadows

1151-001: Supervised Exercise Therapy Versus Percutaneous Transluminal Angioplasty for Claudication By Level Of Disease: A Systematic Review And Meta-Analysis
Sohum Kapadia, Haocheng Huang, Daniela Tirziu, Zain Ahmed, S. Elissa Altin

1208-069: A Black Swan Amidst The Red Herrings: Multi-Organ Dysfunction In The Setting Of Atrial Fibrillation, Severe Mitral Regurgitation, And Pericardial Effusion
Miles Shen, Jiun-Ruey Hu, Jennifer Frampton, Jennifer Kwan

1211-140: Medical Therapy Regimens in Patients With Ischemia And No Obstructive Coronary Artery Disease
Arshjot Khokhar, Natasha Cigarroa, Steffne Kunnirickal, Alexandra N. Schwann, Natalija Odanovic, Steven E. Pfau, Erica Sarah Spatz, Samit Shah

1245-168: Trends and Outcomes in Cardiac Arrest Among Heart Failure Hospitalizations
Fouad Chouairi, Daniel Loriaux, Sounok Sen, Jason Neil Katz, Tariq Ahmad, Paul Elliott Miller, Marat Fudim

1271-007: Operator And Institutional Variability Of Guideline Directed Medical Therapy In Patients Undergoing Peripheral Vascular Interventions
Kim G. E. Smolderen, Gaëlle Romain, Carlos Mena Hurtado

1272-016: Sex Differences In Impella Supported High Risk Percutaneous Coronary Intervention Outcomes
Tayyab Shah, Cindy L. Grines, Suzanne Baron, Yanru Li, Arsalan Abu Much, Yasin Hussain, Jason R. Wollmuth, Wayne B. Batchelor, Mir Babar Basir, William W. O'Neill, Alexandra J. Lansky

1283-039: Foundation-Academic Partnership For ECG Screening Of University Varsity Athletes
Mike Papale, Maria Cantito, Rachel J. Lampert

1377-014: Sex Differences In Patients With Ischemia And No Obstructive Coronary Artery Disease (Inoca) Undergoing Invasive Physiology Assessment
Natasha Cigarroa, Steffne Kunnirickal, Alexandra N. Schwann, Natalija Odanovic, Arshjot Khokhar, Steven E. Pfau, Erica Sarah Spatz, Samit Shah

1390-033: Deep Learning-Based Detection of Left Ventricular Systolic Dysfunction from Noisy Single Lead Electrocardiography Adapted for Wearable Devices
Akshay Khunte, Veer Sangha, Lovedeep Dhingra, Evangelos K. Oikonomou, Bobak Mortazavi, Rohan Khera

1025-07: Comparative Effectiveness of Endovascular and Open Bypass Interventions for Below rhe Knee Chronic Limb-Threatening Ischemia: A Propensity-Matched Analysis Using Medicare-Linked Vascular Quality Initiative Outcomes Data
Jacob Cleman, Gaëlle Romain, Scott Grubman, Kim G. E. Smolderen, Carlos Mena Hurtado

1031-07: Mechanistic Evaluation Of An Ai-Driven Clinical Decision Support Tool To Personalize The Use Of Anatomical Testing In Suspected Coronary Artery Disease
Evangelos K. Oikonomou, Marc Suchard, Edward James Miller, Eric J. Velazquez, Rohan Khera

1032-09: Multinational Patterns Of Second-Line Anti-Hyperglycemic Drug Initiation In Established Cardiovascular Disease: A Federated Pharmacoepidemiologic Evaluation In LEGEND-T2DM
Rohan Khera, Lovedeep Dhingra, Kelly Li, Arya Aminorroaya, Jin Zhou, Faaizah Arshad, Fan Bu, David Dorr, Thomas Falconer, Tina French, Wallis Lau, Yuan Lu, Kenneth Man, Michael Edwin Matheny, Evan Minty, Akihiko Nishimura, Anna Ostropolets, Sarah Seager, Wan Eric Y.F., Jianxiao Yang, Can Yin, George Hripcsak, Harlan M. Krumholz, Marc Suchard, and LEGEND-T2DM Investigators

1034-11: Associations Between Perceived Level Of Social Support And Disease Specific Outcomes In Patients With Symptomatic Peripheral Artery Disease: Insights From The Portrait Registry
Madeleine M. Hardt, Gaëlle Romain, Carlos Mena Hurtado, Kim G. E. Smolderen

1034-13 - Age of Menopause And Incident Peripheral Artery Disease Admissions For Women In The Atherosclerosis Risk In Communities (Aric) Study
Lindsey Scierka, Carlos Mena Hurtado, Gaëlle Romain, Jeffrey R. Bender, Kunihiro Matsushita, Kim G. E. Smolderen

1412-012: Propofol VS Etomidate for Induction Prior to Invasive Mechanical Ventialtion in Patients with Acute Myocardial Infarction
Alexander W. Thomas, Andi Shahu, Tariq Ali, Soumya Banna, Christopher Schenck, Sathvik Namburar, Cory Heck, Paul Elliott Miller

1419-171: The Incidence of Chagas Cardiomyopathy in a Northwestern Community of Córdoba, Argentina
Maria Laura Martinez, Marcos Amuchastegui, Juan Gonzalez Grima, Tomas Amuchastegui, Teresita Alvarellos, Katelyn McNamara, Sanjana Garimella, Ariel Sánchez, Michael Mankbadi, Lorenzo Rakesh Sewanan, Oscar Salomone, Robert L. McNamara, Bernardo Lombo

Mar. 5, 2023

667 - 14: Case Presentation: CAD With Reduced EF
Coronary revascularization with percutaneous coronary intervention or surgery has been a hot topic in cardiology. There have been many debates in regard to left main revascularization whether CABG or PCI is best, management of stable ischemic heart disease, approach to revascularization in heart failure. This session will aim to provide guidance on how to approach coronary revascularization by reviewing the current guidelines and clinical trials data.
Yousif Ahmad

676-08: Diagnosis of ICI Myocarditis: How Accurate Is Cardiac MR?The participants will gain understanding about the use of cardiac imaging.
Lauren Anne Baldassarre

686-12: The Impact of Behavior Health in Comprehensive PAD Care
The focus of this session is to review the role of pharmacotherapies in the treatment of peripheral arterial disease, as well as disparities in care, and novel care delivery models to optimize outcomes.

Kim G. E. Smolderen

695-09: Evolution of ECG Criteria for Athletes
The debate regarding the need to screen young competitive athletes with ECG remains hot and controversial. To date, evidence moving the needle remains sparse, however important points in favor and against this practice remain. In addition, improvements in ECG interpretation in athletes has evolved. This session is geared to review the evolution of ECG interpretation for athletes and to debate the use of ECG screening for athletes.
Rachel J. Lampert

696-06: Women Are Not Smaller Men! Unique Factors That Impact Women’s Heart Health Throughout the Lifespan: Featuring the 2023 Douglas P. Zipes Distinguished Awardee Keynote
Cardiovascular disease is the leading cause of death in women. There are sex differences in the risk conferred by traditional risk factors. Additionally, women experience unique risk factors throughout the lifespan related to hormones, pregnancy and menopause. Other emerging risk factors such as autoimmune disease and mental health disorders may impact women's heart health to a greater extent. This session focus on CV risk factors that are female specific or female predominant, focusing on screening and implications for prevention.

Erica Sarah Spatz

707-14 - Putting the Patient First: Shared Decision Making With Chest Pain Patients
The goals of this session are to highlight key topics from the chest pain guidelines with a focus on the management of acute chest pain. The session will start with a case and didactic talks defining patient risk, review high sensitivity troponins, and how to implement clinical decision pathways in triage of acute chest pain. This will set the stage for a debate focusing on anatomic versus functional testing in the evaluation of acute chest pain. After the debate, we will review non-ischemic causes of chest pain and concluding the session with a review of shared decision making.

Erica Sarah Spatz

1055-02: Back to Basics and Gained in Translation: Imaging at the Benchside and Bedside
Albert J. Sinusas

1055-07: Rest/Stress Dynamic Computed Tomography Perfusion for Evaluating Peripheral Arterial Disease: Validation in Rabbit Model of Hindlimb Ischemia
Alaa Alashi, Billy Vermillion, Rachel Burns, Supum Lee, Brandon Bingham, Nicole Guerrera, Xenophon Papademetris, Stephanie L. Thorn, Albert J. Sinusas

1066-07: Long-Term Safety and Efficacy of Mavacamten in Patients (Pts) with Symptomatic Obstructive Hypertrophic Cardiomyopathy (HCM): Updated Results from the PIONEER-OLE Study
Ahmad Masri, Steven J. Lester, John Stendahl, Sheila M. Hegde, Amy Sehnert, Ganesh Balaratnam, Shawna Fox, Andrew Wang

1446-005: Risk Of Readmission In Peripheral Artery Disease With Comorbid Opioid Use Disorder And Depression
Megan Lee, Carlos Mena Hurtado, Gaëlle Romain, Madeleine M. Hardt, Kim G. E. Smolderen

1446-008 : Health Status Presentation Thresholds In Real-World Peripheral Artery Disease Specialty Care
Kim G. E. Smolderen, Gaëlle Romain, Lindsey Scierka, Jacob Cleman, Shannon Lynch, Sameer Nagpal, Carlos Mena Hurtado

1453-139: Proton Pump Inhibitors VS Histamine Type 2 Receptor Blockers for Stress Ulcer Prophylaxis in Mechanically Ventilated Patients with Acute Myocardial Infarction
Soumya Banna, Christopher Schenck, Sathvik Namburar, Andi Shahu, Alexander W. Thomas, Cory Heck, Tariq Ali, Paul Elliott Miller

1494-187: In Patients Undergoing Nuclear Myocardial Perfusion Imaging, Rheumatoid Arthritis Is Associated With Increased Risk Of Adverse Cardiovascular Events Independent Of Myocardial Ischemia
Jacqueline Pires, Evangelos K. Oikonomou, Ritu Agarwal, Yi-Hwa Liu, Edward James Miller, Albert J. Sinusas, Attila Feher

1499-034: Deep Learning-Based Identification Of Heart Failure With Reduced Ejection Fraction In Clinical Documentation To Automate Care Quality Assessment In Heart Failure
Arash Nargesi, Benjamin Rosand, Astrid Hengartner, Philip Adejumo, Rohan Khera

1525-184: Coronary Atherosclerosis Based on Atherogenic Lipoproteins in an Asymptomatic U.S. Population without Conventional Risk Factors: from the Miami Heart Study
Kamil Faridi, Shubham Lahan, Miguel Cainzos-Achirica, Ricardo C. Cury, Theodore Feldman, Alan Pan, Jonathan A. Fialkow, Khurram Nasir

1534-033 : A Machine Learning-Guided Approach For Adaptive Trial Enrichment And Acceleration Of Cardiovascular Outcome Trials: Insights From The SPRINT And ACCORD-BP Trials
Evangelos K. Oikonomou, Erica Sarah Spatz, Joseph S. Ross, Marc Suchard, Harlan M. Krumholz, Rohan Khera

1537-136: Sex Difference in Causes and Timing of One-Year Outcomes Among Young Acute Myocardial Infarction Patients; Results from the Virgo Study
Mitsuaki Sawano, Yuan Lu, Cesar Caraballo, Shiwani Mahajan, Rachel P. Dreyer, Judith H. Lichtman, Gail D'Onofrio, Erica Sarah Spatz, Rohan Khera, Oyere Onuma, Karthik Murugiah, John A. Spertus, Harlan M. Krumholz

1560-169: What is the Value of Repeated Nt-Probnp Measurements in Chronic Heart Failure with Reduced Ejection Fraction?
Michael A. Fuery, Eric Leifer, Marc Samsky, Sounok Sen, Christopher M. O'Connor, Mona Fiuzat, Justin A. Ezekowitz, Ileana L. Pina, David J. Whellan, Daniel B. Mark, G. Michael Felker, Nihar R. Desai, James L. Januzzi, JR, Tariq Ahmad

1625-072: Immunosuppression Resistant Immune Checkpoint Inhibitor Induced Myocarditis Treated Successfully with Addition of Tofacitinib
Carlos Felipe Matute Martinez, Nimish Shah, Sanjana Garimella, Jennifer Kwan

1626-136: Rocuronium vs Succinylcholine In Patients With Acute Myocardial Infarction Requiring Mechanical Ventilation
Christopher Schenck, Soumya Banna, Andi Shahu, Alexander W. Thomas, Sathvik Namburar, Cory Heck, Tariq Ali, Paul Elliott Miller

1629-175: Association Of Metabolic Syndrome, Inflammation, Coronary Artery Calcium Score, And Incident Cardiovascular Disease
Olayinka J. Agboola, Jeph Herrin, Erica Sarah Spatz

1659-061: Hidden In A Plain Sight: Large Atrial Myxoma In A Patient Presenting With Chest Pain
Samdish Sethi, Gini Priyadharshini Jeyashanmugaraja, Evgeny Shkolnik

1664-189: Coronary Artery Calcifications Are a Better Predictor of Cardiovascular Outcomes Than Ischemic Ecg Changes In Patients With Normal Perfusion on Exercise Spect
Tiantian Shi, Damianos Kokkinidis, Ritu Agarwal, Yi-Hwa Liu, Albert J. Sinusas, Edward James Miller, Attila Feher

1669-034: Instant Digital Consult: Guideline Directed Medical Therapy In Patients With Heart Failure With Reduced Ejection Fraction And Kidney Disease
Jia Wei Tan, Jiun-Ruey Hu

Mar. 6, 2023

413-06: Vigorous Exercise In Individuals With Hypertrophic Cardiomyopathy (HCM): Primary Results Of The Prospective, Multinational Lifestyle And Exercise In HCM (LIVE-HCM) Study
Rachel J. Lampert

744-01: The Next Generation of Heart Transplantation
There have been a number of recent advancements in cardiac transplantation including Xenotransplantation and the use of Donation after Circulatory Death. The current state of these advances in cardiac transplantation will be reviewed in the context of ethics and equity in the field.

Katherine Clark

756-10 - Opportunities and Potential Solutions To Improve AF Care
This session will show how an integrated approach to establishing AF centres of excellence can improve outcomes for patients with AF using a patient-centered approach, including improved Quality of Life, reduced morbidity from stroke, heart failure and AF symptoms, and reduced mortality. The goals of centres should include reducing gaps in health care, and reducing health inequalities across the system, through a more integrated approach to AF management to overcome the current disjointed approach to care. The session will provide practical approaches to achieving these goals in a variety of healthcare settings, in different resource settings.

James V. Freeman

763-09: Deprescribing Debate Pro: Statins
This debate-based session will explore issues surrounding healthy vascular aging, including topics such as deprescribing statins, optimal medical therapy for heart failure, frailty, and old adults in clinical trials.

Michael Nanna

1076-11: Procedure Volume And Outcomes With Watchman Left Atrial Appendage Closure: A Report From The Ncdr Laao Registry
Daniel J. Friedman, Chengan Du, Zhenqiu Lin, Sreekanth Vemulapalli, Andrzej Kosinski, Jonathan P. Piccini, SR, Lucy Pereira, Karl E. Minges, Frederick A. Masoudi, Kamil Faridi, Jeptha P. Curtis, James V. Freeman

1080-03 - Markup on Common Generic Medications at Hospitals in the United States: A Nationally Representative Evaluation
Rohan Khera, Emefah Loccoh, Amanda Nguyen, Diane Li, Lauren Chase, Haider Warraich

1695-072: Persistent Hemolysis After Paravalvular Mitral Regurgitation Closure: Delayed Plug Embolization
Gini Priyadharshini Jeyashanmugaraja, David Narotsky, Chirag A. Shah, Richard L. Taikowski, Evgeny Shkolnik

1701-187: RB-82 PET Derived Regional Myocardial Blood Flow Is Associated With All-Cause Mortality In Patients Presenting With Acute Chest Pain
Camila Trejo-Paredes, Jiun-Ruey Hu, Samit Shah, Yi-Hwa Liu, Kim G. E. Smolderen, Carlos Mena Hurtado, Albert J. Sinusas, Edward James Miller, Cesia Maria Gallegos Kattan

1727-013: Periprocedural Complications In Older Adults Receiving Complex Percutaneous Coronary Intervention
Jonathan Hanna, Stephen Yishu Wang, Ahmed Abdullah, Dae Yong Park, Michael Nanna

1732-096: Three Times A Charm: A Case Of Recurrent Chest Pain
Camila Trejo-Paredes, Jiun-Ruey Hu, Samit Shah, Cesia Maria Gallegos Kattan

1775-035: Biometric Contrastive Modeling for Data-Efficient Deep Learning from Electrocardiographic Images
Veer Sangha, Akshay Khunte, Gregory Holste, Bobak Mortazavi, Zhangyang Wang, Evangelos K. Oikonomou, Rohan Khera

1812-033: Smart-As: A Novel Artificial Intelligence Tool to Detect Severe Aortic Stenosis From Electrocardiographic Images
Veer Sangha, Evangelos K. Oikonomou, Akshay Khunte, Kartikeye Gupta, Bobak Mortazavi, Rohan Khera

Submitted by Elisabeth Reitman on January 26, 2023