People

Dr. Mane brings expertise for genomic and proteomic analyses using both microarray and high-throughput DNA sequencing technologies. He received his Ph.D. in Cancer Biology in 1985 and did his Postdoc at the Johns Hopkins University School of Medicine. He is the Director of the Yale Center for Genome Analysis (YCGA) Shared Resource and the Director of The Keck Biotechnology Resource Laboratory at Yale. He has published more than 125 articles, holds 2 patents, and has amassed over 25 years of research experience in both academic and private industry. He has attracted significant funding from NIH and other sources to maintain cutting edge genomic technologies at Yale. Currently, Dr. Mane is one of four PIs of the Yale Center for Mendelian Genomics established in 2012 through an $11.2 million-dollar grant from NHGRI. Besides directing the YCGA, he pursues research in the field of neuroscience. Dr. Mane has a demonstrated record of establishing a successful and productive genomic facility that has provided over 58,000 sequence analyses (library prep, sequencing and analyses) to 225 Yale and 124 non-Yale principal investigators from 72 national and 16 international institutions.

As a director of operations at YCGA, Bony De Kumar has over 20 years of experience in genomics, epigenetics, and Bioinformatics. After Postdoctoral Research, he served as a genomics Scientist at Jackson Lab, Bar Harbor, and as director of genomics core at the University of North Dakota, Grand Forks. He has successfully established long-read technologies (Nanopore and PacBio) at the Bar Harbor campus to cater to genotyping needs. At the University of North Dakota (UND), As a core director at UND, he has initiated single-cell genomics, spatial transcriptomics, and long-read sequencing at UND alongside the expansion of new short-read-based library preparation. His group offers DNA and RNA library preparation, spatial transcriptomics, and sequencing services to Yale and Non-yale users of YCGA. Research interests included the development of technology for liquid biopsies, newborn screening, and epigenetics.

As director of YCGA’s Bioinformatics Core, James Knight has over 33 years of experience in bioinformatics and computational biology. After his Ph.D. and post-doctoral work, he served a lead bioinformatician at the genomics companies CuraGen Corporation and 454 Life Sciences. At 454 Life Sciences, the first company to commercialize next-generation sequencing (NGS), he was the lead author of the Newbler assembler and a lead in the development of 454’s bioinformatics software. Joining Yale in 2014, he and his group provide NGS analysis services across the Yale community, covering all sequencing technologies and analysis applications.

Amanda Leigh is YCGA’s Administrative Assistant. Being at YCGA for over 5 years and working alongside the Leadership and C&T teams, Amanda brings extensive experience for expenses and scheduling. After earning an B.A. from The University of Connecticut, she’s worked as an admin/assistant at Yale University in the Yale Medical Group and General Medicine before landing at West Campus with the Genome Center. In addition to her position at YCGA, Amanda enjoys time with her husband and family and actively volunteering within the community and her sons’ school.