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About Recurrent Pregnancy Loss (RPL)

  • Recurrent pregnancy loss (RPL) is defined as experiencing two or more pregnancy losses.
  • RPL affects ~5% of couples worldwide which equates to millions of couples and their families.
  • ~50% of couples with RPL remain without an identifiable cause after all the currently recommended testing for RPL has been done.
  • The recurrent aspect of RPL suggests the possibility of a genetic cause (when neither parent has a confirmed health condition that is well-documented to cause pregnancy loss).
  • Our genetic material (or DNA, short for deoxyribonucleic acid) is organized into ~20,000 genes.
  • These genes provide the instructions that tell our bodies how to grow, develop, and function.
  • RPL is stressful and often traumatic for couples and their families.
  • The causes of RPL are not well understood.
  • This lack of knowledge makes it difficult to provide effective medical care for couples with RPL.