Yale Genetics Research Labs

The DiMaio laboratory is studying the molecular mechanisms of how human papillomaviruses enter cells, with a particular focus on identifying the cellular proteins that mediate virus entry and intracellular trafficking and determining their molecular mechanisms of action.

The Hall lab builds new computational methods and data resources to better analyze human genomes, and using high-throughput DNA sequencing technologies to study genome variation and disease. The lab is interested in basic aspects of genome biology including the mutational causes and molecular consequences of genetic variation.

The Jiang lab aims to uncover the molecular and neurological bases and develop novel therapies for neurodevelopmental (autism spectrum disorder) and neurogenetic disorders caused by genetic or epigenetic defects.

The Krishnaswamy lab works at the intersection of computer science, applied math, computational biology, and signal processing to develop representation-learning and deep learning methods that enable exploratory analysis, scientific inference and prediction from big biomedical datasets.

The Lek lab is focused on understanding the genetic mechanism of rare diseases that may lead to rational approaches for therapies, and is particularly focussed on improving the diagnosis of rare neuromuscular diseases.

The Lu laboratory studies noncoding and epigenetic regulation of hematopoiesis and cancer, with a current focus on 1. Epigenetic mechanisms that control solid cancer and immune cell crosstalk; 2. Noncoding RNAs in normal hematopoiesis and leukemia; 3. Finding novel functional noncoding sequences in the genome.

Dr. Mane is the Director of the Yale Center for Genome Analysis (YCGA) and the Director of The Keck Biotechnology Resource Laboratory at Yale. Besides directing the YCGA, he pursues research in the field of neuroscience.

The Reilly lab develops and applies new high-throughput experimental approaches to interrogate the genome, such as non-coding CRISPR screens and the Massively Parallel Reporter Assay. Computationally, we also develop machine-learning approaches to predict the functions of these CRE perturbations.

The Weissman laboratory has worked extensively on cDNA technology and the use of RNA for cell redirection. Recently the Weissman laboratory has been using genome scale analysis of small numbers of cells and individual cells to obtain insights into early steps in renewal and differentiation of multipotent cells.