Skip to Main Content


  • We hope to recruit 1,000 couples with RPL from 13 sites across the United States who remain without an explanation for their history of RPL after clinical evaluation.
  • Whole genome sequencing (WGS) and other bioinformatic tests will be performed for research study participants.
  • We expect to find disease-causing “typos” (pathogenic/likely pathogenic variants) in genes that are critical for fetal and placental development and a successful pregnancy.
  • Ultimately, our findings may improve the clinical care of couples with a history of RPL.
  • This research study is funded by the National Institutes of Health (NIH).

You may be eligible if:

  • You are older than 18 years old.
  • You recently experienced a pregnancy loss at < 20 weeks gestation.
  • You have experienced two or more unexplained pregnancy losses in the past (in addition to your most recent pregnancy loss).
  • Both biological parents of your most recent pregnancy loss are willing to participate.
  • Your most recent pregnancy loss did not involve an egg and/or sperm donor.
  • Your clinical evaluation for RPL has not revealed an explanation.

Participation in this Research Study Involves:

  • A blood sample from both biological parents of your most recent pregnancy
  • Access to your miscarriage sample(s)
  • Access to your medical records
  • Willingness to undergo additional clinical evaluation (if necessary) to determine your eligibility for this research study

Participate in Our Research