Sidi Chen, PhD

Assistant Professor

Departments & Organizations

Genetics: Sidi Chen Lab

Center for Biomedical Data Science

Center for RNA Science and Medicine

Liver Center

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Immunology | Molecular Cell Biology, Genetics and Development

Yale Stem Cell Center


Sidi Chen joined the Yale Faculty in 2015 as an assistant professor in the Department of Genetics and Systems Biology Institute, also as a member of the Yale Cancer Center and the Yale Stem Cell Center. Chen earned a PhD in evolutionary genetics from The University of Chicago with an award-winning dissertation with Dr. Manyuan Long. After graduation he performed postdoctoral studies at MIT under the mentorship of Dr. Phil Sharp, and also the Broad Institute working with Dr. Feng Zhang. His research focuses on providing a global understanding of biological systems. Leveraging functional genomics and the emerging genome editing technologies and genome-wide in vivo screens, his work has identified and characterized young essential genes, illuminated the regulation of hypoxia and angiogenesis by microRNAs, and developed precision CRISPR-based in vivo models of cancer, and global mapping of functional drivers of cancer oncogenesis and metastasis. His laboratory currently works to develop and apply novel tools for next-generation cancer genetics, genomics and systems biology, and tackle problems in cancer initiation, progression, metastasis, immunity, and therapeutic responses. His group is also interested in developing innovative next generation immunooncology therapeutics. Dr. Chen was selected as a Damon Runyon Cancer Research Fellow in 2012 and won the Dale Frey Award for Breakthrough Scientists in 2015. He has also been recognized with a series of awards such as AACR NextGen Award for Transformative Cancer Research, TMKF Innovative/Translation Cancer Research Award, Exceptional Research Grant Award from the Breast Cancer Alliance, Young Investigator Awards from Melanoma Research Alliance, V Scholar, Bohmfalk Scholar, Ludwig Family Foundation St. Baldrick’s Foundation, and Clinic & Laboratory Integration Program (CLIP) from Cancer Research Institute. His lab also receives funding from National Institute of Health and Department of Defense.

Education & Training

PhD The University of Chicago (2011)
Visiting Postdoc Broad Institute of MIT and Harvard
Postdoctoral Fellow MIT
Visiting Student Stanford University

Honors & Recognition

  • Distinguished Scientist AwardSontag Foundation (2018)

  • NIH Director's New Innovator Award (DP2)NIH OD / NCI (2018)

  • Ludwig Family Foundation (2018)

  • Bohmfalk Scholar in Medical Research (2017)

  • LCRP Idea Development AwardDepartment of Defense (2017)

  • AACR NextGen Award for Transformative Cancer ResearchAACR (2017)

  • Exceptional Research Grant AwardBreast Cancer Alliance (2017)

  • St. Baldrick’s Foundation Award (2016)

  • Young Investigator AwardMelanoma Research Alliance (2016)

  • Dale Frey Award for Breakthrough ScientistsDamon Runyon Cancer Research Foundation (2015)

  • Damon Runyon Cancer Research FellowshipDamon Runyon Cancer Research Foundation (2012)

  • Best Dissertation AwardThe University of Chicago (2011)

  • Chair’s Special Award, Best PresentationGordon Research Conference (2011)

  • National Science Foundation Doctoral Dissertation Improvement GrantNational Science Foundation (2010)

  • Chun-Tsung ScholarTsung-Dao Lee Foundation (2002)

Edit this profile

Contact Info

Sidi Chen, PhD
Lab Location
Sidi Chen LaboratoryWest Campus Integrative Science & Technology Center
850 West Campus Drive, Rm 314

West Haven, CT 06516
View on map...
Mailing Address
Genetics850 West Campus Drive
Integrated Science & Technology Center

West Haven, CT 06516

Curriculum Vitae

Chen Lab website