Goals
- We hope to recruit 1,000 couples with RPL from 13 sites across the United States who remain without an explanation for their history of RPL after clinical evaluation.
- Whole genome sequencing (WGS) and other bioinformatic tests will be performed for research study participants.
- We expect to find disease-causing “typos” (pathogenic/likely pathogenic variants) in genes that are critical for fetal and placental development and a successful pregnancy.
- Ultimately, our findings may improve the clinical care of couples with a history of RPL.
- This research study is funded by the National Institutes of Health (NIH).
You may be eligible if:
- You are older than 18 years old.
- You recently experienced a pregnancy loss at < 20 weeks gestation.
- You have experienced two or more unexplained pregnancy losses in the past (in addition to your most recent pregnancy loss).
- Both biological parents of your most recent pregnancy loss are willing to participate.
- Your most recent pregnancy loss did not involve an egg and/or sperm donor.
- Your clinical evaluation for RPL has not revealed an explanation.
Participation in this Research Study Involves:
- A blood sample from both biological parents of your most recent pregnancy
- Access to your miscarriage sample(s)
- Access to your medical records
- Willingness to undergo additional clinical evaluation (if necessary) to determine your eligibility for this research study