Affective Disorders, Psychotic; Alcoholism; Anxiety Disorders; China; Genetics; Genetics, Population; Israel; Polymorphism, Genetic; Psychiatry; Stress Disorders, Post-Traumatic; Thailand; Global Health; Substance-Related Disorders
Psychiatry: Center for the Translational Neuroscience of Alcoholism | Human Genetics, Division of | Molecular Psychiatry, Division of | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Neuroscience Research Training Program (NRTP) | Psychotherapy Development Center | Stress & Addiction Clinical Research Program | VA Alcohol Research Center | VA-Yale Clinical Neurosciences PTSD Research Program
The research focus of my laboratory is genetics of psychiatric illness. We study a range of behavioral phenotypes including cocaine, opioid, nicotine, and alcohol dependence, PTSD, panic and other anxiety disorders. In addition we study a range of intermediate phenotypes, such as neuroimaging measures; and basic issues in population and complex trait genetics.
The overall approach involves study of genetic polymorphism and sequence variation, on a molecular level, and from the perspective of population genetics. Current studies include multicenter case/control association studies with the goal of identifying genes predisposing to cocaine, opioid, nicotine, and alcohol dependence (using genomewide association analysis and other approaches); a whole exome sequencing study of methamphetamine dependence, in Thailand; an international drug dependence genetics training project in collaboration with Chulalongkorn Faculty of Medicine (Bangkok, Thailand); studies of posttraumatic stress disorder (PTSD); and a VA study on the pharmacogenomics of antidepressant response. I also co-lead the Substance Use Disorders group of the Pschiatric Genomics Consortium.
Specialized Terms: Complex trait genetics; Psychiatric genetics; Population genetics; Substance dependence; Pharmacogenomics
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA. (2014) Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.
Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, and Gelernter J (2011) Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.
Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.
Sherva R, Wang Q, Kranzler H, Zhao H, Koesterer R, Herman A, Farrer LA, Gelernter J. JAMA Psychiatry. 2016 May 1;73(5):472-80. doi: 10.1001/jamapsychiatry.2016.0036.
Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS.
Wang Q, Yang C, Gelernter J, Zhao H. Hum Genet. Sep 4.
Dissecting ancestry genomic background in substance dependence genome-wide association studies.
Polimanti R, Yang C, Zhao H, Gelernter J. Pharmacogenomics. 2015 Aug;16(13):1487-98. doi: 10.2217/pgs.15.91. Epub 2015 Aug 12.
A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke.
Jensen KP, Smith AH, Herman AI, Farrer LA, Kranzler HR, Sofuoglu M, Gelernter J. Mol Psychiatry. 2016 Apr 12. doi: 10.1038/mp.2016.43. [Epub ahead of print]
Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women.
Polimanti R, Kranzler HR, Gelernter J. Neuropsychopharmacology. 2016 Oct;41(11):2688-96. doi: 10.1038/npp.2016.72. Epub 2016 May 17.
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans
Gelernter J, Kranzler HR, Sherva R, Almasy L, Herman AI, Koesterer R, Zhao H, Farrer LA. Biol Psychiatry. 2015 Mar 1;77(5):493-503. doi: 10.1016/j.biopsych.2014.08.025. Epub 2014 Sep 16