Tyrone Cannon
Clark L. Hull Professor of Psychology and Professor of PsychiatryCards
Appointments
Department of Psychology
Primary
Psychiatry
Secondary
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About
Titles
Clark L. Hull Professor of Psychology and Professor of Psychiatry
Appointments
Department of Psychology
ProfessorPrimaryPsychiatry
ProfessorSecondary
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Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Tyrone Cannon's published research.
Publications Timeline
A big-picture view of Tyrone Cannon's research output by year.
Scott Woods, MD
Thomas McGlashan, MD
Vinod H. Srihari, MD
Albert Powers, MD, PhD
Brenda Cabrera-Mendoza, MD/PhD
Christopher Pittenger, MD, PhD
37Publications
26Citations
Publications
2024
Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis
Deng W, Chong B, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39260565, DOI: 10.1016/j.bpsc.2024.08.020.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PTrajectory groupsMaintenance of symptomsOnset of psychosisNon-convertersHealthy controlsDiagnostic constructSymptom trajectoriesPsychosisAffective comorbiditiesAssess symptomsHeightened riskFunctional impairmentSymptomsEtiological risk factorsFunctional outcomesImminent onsetLevels of intensityRemissionRisk factorsIndividualsPhase 3DistressImpairmentPolygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder
Song J, Pasman J, Johansson V, Kuja-Halkola R, Harder A, Karlsson R, Lu Y, Kowalec K, Pedersen N, Cannon T, Hultman C, Sullivan P. Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder. JAMA Psychiatry 2024, 81 PMID: 39196586, PMCID: PMC11359115, DOI: 10.1001/jamapsychiatry.2024.2406.Peer-Reviewed Original ResearchAltmetricConceptsPolygenic risk scoresGenome-wide association studiesSwedish Twin RegistryBipolar disorderCase-control studyTwin concordanceTwin heritabilityLevels of polygenic risk scoreTwin RegistrySwedish national register dataCompare polygenic risk scoresRisk scoreNational register dataHeritable psychiatric disorderAffected co-twinsPairs of twinsPsychosis phenotypeIllness vulnerabilityClinical interviewPsychiatric disordersGenetic liabilityMain OutcomesStructural equation modelingPsychosisSchizophreniaUnique functional neuroimaging signatures of genetic versus clinical high risk for psychosis
Schleifer C, Chang S, Amir C, O'Hora K, Fung H, Kang J, Kushan-Wells L, Daly E, Di Fabio F, Frascarelli M, Gudbrandsen M, Kates W, Murphy D, Addington J, Anticevic A, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Uddin L, Kumar K, Hoftman G, Bearden C. Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis. Biological Psychiatry 2024 PMID: 39181389, DOI: 10.1016/j.biopsych.2024.08.010.Peer-Reviewed Original ResearchAltmetricConceptsBrain signal variabilityClinical high riskCHR individualsTD controlsSubthreshold psychosis symptomsResting-state functional MRIFunctional brain alterationsAssociated with psychosisFunctional brain measuresGroup difference mapCopy number variantsCase-control differencesPsychosis symptomsNeural substratesBrain alterationsBrain measuresLocal connectivityFunctional MRIFunctional connectivityCortical regionsNeuroimaging signaturesNeurodevelopmental disordersPsychosisHigh riskBrain mappingSleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis
Cohen S, Goldsmith D, Ning C, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Woods S, Walker E, Miller B. Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis. Psychiatry Research 2024, 341: 116147. PMID: 39197223, DOI: 10.1016/j.psychres.2024.116147.Peer-Reviewed Original ResearchAltmetricConceptsPsychosis-risk symptomsClinical high riskSuicidal ideationCHR-P individualsCHR-PSleep disturbanceTerminal insomniaNorth American Prodrome Longitudinal StudyAssociated with conversion to psychosisSleep problemsConversion to psychosisTreatment of sleep disturbancesAssociated with SIIndices of sleep disturbanceMultiple indicesPsychosisIdeationLongitudinal intervention studyInsomniaLongitudinal studySchizophreniaSymptomsSleepSymptom scoresInvestigate relationshipsOccasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts
Kennedy L, Ku B, Addington J, Amir C, Bearden C, Cannon T, Carrión R, Cornblatt B, Keshavan M, Perkins D, Mathalon D, Stone W, Walker E, Woods S, Cadenhead K. Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts. Schizophrenia Research 2024, 271: 319-331. PMID: 39084107, DOI: 10.1016/j.schres.2024.07.032.Peer-Reviewed Original ResearchConceptsClinical high riskCannabis use frequencyPremorbid functioningCannabis usePsychosis cohortSocial functioningCannabis usersAssociated with greater symptom severityAssociated with better neurocognitionNorth American Prodrome Longitudinal StudyClinical high-risk participantsClinical high-risk youthClinical high-risk populationsUse groupRates of cannabis useCannabis use groupsMeasures of IQCannabis use patternsGreater symptom severityHigher premorbid functioningFollow-up analysisPsychosis sampleHigher IQNeurocognitive domainsFirst-episodeWhole genome sequencing study of identical twins discordant for psychosis
Ormond C, Ryan N, Hedman A, Cannon T, Sullivan P, Gill M, Hultman C, Heron E, Johansson V, Corvin A. Whole genome sequencing study of identical twins discordant for psychosis. Translational Psychiatry 2024, 14: 313. PMID: 39080272, PMCID: PMC11289105, DOI: 10.1038/s41398-024-02982-0.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCopy number variantsSequencing studiesGenic copy number variantsWhole-genome sequencing studiesRare genic copy number variantsDeleterious missense variantsWhole-genome sequencingExome sequencing studiesGenome sequencing studiesMZ twinsPost-zygotic eventsPairs of MZ twinsGenome sequenceIdentical genomesDNA variantsMissense variantsOverlapped genesPsychotic phenotypesPsychotic disordersBipolar disorderRare variantsMZ twin studiesPhenotypic discordanceTwin studiesTwin pairsRobust Brain Correlates of Cognitive Performance in Psychosis and its Prodrome
Ward H, Beermann A, Xie J, Yildiz G, Felix K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Coleman M, Bouix S, Holt D, Öngür D, Breier A, Shenton M, Heckers S, Halko M, Lewandowski K, Brady R. Robust Brain Correlates of Cognitive Performance in Psychosis and its Prodrome. Biological Psychiatry 2024 PMID: 39032726, DOI: 10.1016/j.biopsych.2024.07.012.Peer-Reviewed Original ResearchAltmetricConceptsAuditory continuous performance taskConnectome-wide association studiesEarly psychosisCognitive performanceNorth American Prodrome Longitudinal Study 2At-risk individualsCorrelates of cognitive performanceBrain-cognition relationshipsBrain-phenotype relationshipsBrain-behavior associationsContinuous performance taskEarly-course psychosisLongitudinal Study 2Resting-state fMRIProspective study of individualsHuman Connectome ProjectPsychosis onsetStudy of individualsPsychosisStudy 2Performance tasksNeurocognitive impairmentCognitive instrumentsHealthy participantsRobust associationsSex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis
Chintoh A, Liu L, Braun A, Akseer S, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, McGlashan T, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Addington J. Sex differences in clinical presentation in youth at high risk for psychosis who transition to psychosis. Schizophrenia Research 2024, 271: 153-160. PMID: 39029145, DOI: 10.1016/j.schres.2024.07.030.Peer-Reviewed Original ResearchAltmetricConceptsClinical high riskClinical high-risk individualsSex differencesNegative symptomsTransition to psychosisInvestigate sex differencesNo sex differencesSchizophreniform disorderCHR individualsPsychosisSubstance useSchizophreniaSymptomsHigh riskIndividualsSchizophreniformAnxietyClinical presentationSexDepressionDisordersBaselineDifferencesMaleYouthNeurocognition in adolescents and young adults at clinical high risk for psychosis: Predictive stability for social and role functioning
Carrión R, Ku B, Dorvil S, Auther A, McLaughlin D, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cornblatt B. Neurocognition in adolescents and young adults at clinical high risk for psychosis: Predictive stability for social and role functioning. Schizophrenia Research 2024, 271: 129-137. PMID: 39024961, DOI: 10.1016/j.schres.2024.06.054.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PNeurocognitive deficitsImpact of processing speedProcessing speedNorth American Prodrome Longitudinal StudyBaseline processing speedCHR-P participantsPoor social functioningCHR-P individualsYoung adultsDisorganized symptomsBaseline neurocognitionAttentional impairmentAttention deficitDevelopmental trajectoriesNeurocognitionPsychosisImpact of symptomsProdromal phaseSocial functioningIntervention issuesTreatment targetLongitudinal studyDeficitsGenetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health
Kouakou M, Cabrera-Mendoza B, Pathak G, Cannon T, Polimanti R. Genetically Informed Study Highlights Income-Independent Effect of Schizophrenia Liability on Mental and Physical Health. Schizophrenia Bulletin 2024, sbae093. PMID: 38848523, DOI: 10.1093/schbul/sbae093.Peer-Reviewed Original ResearchAltmetricConceptsMultivariable Mendelian randomizationMR analysisMedical endpointsMultivariable MR analysisNegative health outcomesSubstance usePsychiatric Genomics ConsortiumHigh-risk individualsFinnGen participantsMendelian randomizationMultiple testing correctionSocioeconomic inequalitiesHealth outcomesBonferroni multiple testing correctionUK BiobankSocioeconomic differencesPhysical healthMental healthAnalysis of schizophreniaGenetic liabilityAdjustment disorderHousehold incomeLife expectancyTesting correctionPersonality disorder
News
News
- September 16, 2020
Yale Researchers to Lead $52M Investigation Into Cause, Effect of Schizophrenia in Some High-risk Adolescents
- July 05, 2020
Brain Imaging Reveals Patterns That Foreshadow Schizophrenia’s Onset
- February 19, 2019
Cannon appointed Chair of Department of Psychology at Yale University
- July 01, 2016
Yale study: Calculator can predict psychosis risk