2023
F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK
Zhou H, Yang B, Kranzler H, Gelernter J. F101. MENDELIAN RANDOMIZATION ANALYSIS OF THE EFFECTS OF ALCOHOL USE ON CANCER RISK. European Neuropsychopharmacology 2023, 75: s274. DOI: 10.1016/j.euroneuro.2023.08.480.Peer-Reviewed Original ResearchInverse variance weightingAlcohol useCancer riskOral/pharyngeal cancerOral cancer riskMendelian randomizationMendelian randomization analysisCumulative epidemiological evidenceSpecific cancer typesDevelopment of cancerPharyngeal cancerEsophageal cancerEpidemiological evidenceProblematic alcohol useAlcohol consumptionUnderreported populationCancerCancer typesMR studiesMR-PRESSOAlcohol-related phenotypesDifferent cancersRandomization analysisBreastMR-Egger
2022
Cigarette Smoking and Risk of Different Pathologic Types of Stroke: A Systematic Review and Dose-Response Meta-Analysis
Luo J, Tang X, Li F, Wen H, Wang L, Ge S, Tang C, Xu N, Lu L. Cigarette Smoking and Risk of Different Pathologic Types of Stroke: A Systematic Review and Dose-Response Meta-Analysis. Frontiers In Neurology 2022, 12: 772373. PMID: 35145466, PMCID: PMC8821532, DOI: 10.3389/fneur.2021.772373.Peer-Reviewed Original ResearchDifferent pathologic typesNon-linear dose-response associationDose-response associationRisk of strokePathologic typeOdds ratioCigarette smokingDose-response relationshipCurrent smokersStroke incidenceStroke morbidityDifferent smoking characteristicsDose-Response MetaMortality of strokeProspective cohort studyPooled odds ratioSimilar dose-response relationshipDose-response relationInverse variance weightingSmoking control strategiesStroke preventionCohort studySmoking characteristicsGeneral populationSmokers
2021
Safety considerations for esophageal dilation by anesthetic type: A systematic review
Lerner MZ, Bourdillon AT, Dai F, Brackett A, Kohli N. Safety considerations for esophageal dilation by anesthetic type: A systematic review. American Journal Of Otolaryngology 2021, 42: 103128. PMID: 34216877, DOI: 10.1016/j.amjoto.2021.103128.Peer-Reviewed Original ResearchConceptsEsophageal dilationOffice-based techniqueSystematic reviewDerSimonian-Laird random-effects modelType of anesthesiaSmall case seriesOffice-based proceduresFull-text studiesUse of stentsRandom-effects modelComprehensive literature searchInverse variance weightingAdverse eventsAnesthetic typeCase seriesIntravenous sedationGeneral anesthesiaHigh morbidityAnesthesia techniquesLocal anesthesiaEmbase databasesExclusion criteriaEquivalent safetyPRISMA guidelinesRare disease
2019
No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study
Dong J, Gharahkhani P, Chow WH, Gammon MD, Liu G, Caldas C, Wu AH, Ye W, Onstad L, Anderson LA, Bernstein L, Pharoah PD, Risch HA, Corley DA, Fitzgerald RC, Consortium S, Iyer PG, Reid BJ, Lagergren J, Shaheen NJ, Vaughan TL, MacGregor S, Love S, Palles C, Tomlinson I, Gockel I, May A, Gerges C, Anders M, Böhmer AC, Becker J, Kreuser N, Thieme R, Noder T, Venerito M, Veits L, Schmidt T, Schmidt C, Izbicki JR, Hölscher AH, Lang H, Lorenz D, Schumacher B, Mayershofer R, Vashist Y, Ott K, Vieth M, Weismüller J, Nöthen MM, Moebus S, Knapp M, Peters WHM, Neuhaus H, Rösch T, Ell C, Jankowski J, Schumacher J, Neale RE, Whiteman DC, Thrift AP. No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study. Clinical Gastroenterology And Hepatology 2019, 17: 2227-2235.e1. PMID: 30716477, PMCID: PMC6675666, DOI: 10.1016/j.cgh.2019.01.041.Peer-Reviewed Original ResearchConceptsRisk of BEMendelian randomization studyBarrett's esophagusEsophageal adenocarcinomaInverse variance weightingRandomization studyRisk of EACHydroxy vitamin DVitamin D statusVariance weightingEsophageal Adenocarcinoma ConsortiumD statusEAC riskVitamin DOdds ratioBE riskEsophagusAbstractTextL increaseSingle nucleotide polymorphismsConflicting resultsAdenocarcinomaPatientsSNP associationsRisk
2016
Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study
Ong JS, Cuellar-Partida G, Lu Y, Study A, Fasching P, Hein A, Burghaus S, Beckmann M, Lambrechts D, Van Nieuwenhuysen E, Vergote I, Vanderstichele A, Doherty J, Rossing M, Chang-Claude J, Eilber U, Rudolph A, Wang-Gohrke S, Goodman M, Bogdanova N, Dörk T, Dürst M, Hillemanns P, Runnebaum I, Antonenkova N, Butzow R, Leminen A, Nevanlinna H, Pelttari L, Edwards R, Kelley J, Modugno F, Moysich K, Ness R, Cannioto R, Høgdall E, Høgdall C, Jensen A, Giles G, Bruinsma F, Kjaer S, Hildebrandt M, Liang D, Lu K, Wu X, Bisogna M, Dao F, Levine D, Cramer D, Terry K, Tworoger S, Stampfer M, Missmer S, Bjorge L, Salvesen H, Kopperud R, Bischof K, Aben K, Kiemeney L, Massuger L, Brooks-Wilson A, Olson S, McGuire V, Rothstein J, Sieh W, Whittemore A, Cook L, Le N, Gilks C, Gronwald J, Jakubowska A, Lubiński J, Kluz T, Song H, Tyrer J, Wentzensen N, Brinton L, Trabert B, Lissowska J, McLaughlin J, Narod S, Phelan C, Anton-Culver H, Ziogas A, Eccles D, Campbell I, Gayther S, Gentry-Maharaj A, Menon U, Ramus S, Wu A, Dansonka-Mieszkowska A, Kupryjanczyk J, Timorek A, Szafron L, Cunningham J, Fridley B, Winham S, Bandera E, Poole E, Morgan T, Risch H, Goode E, Schildkraut J, Pearce C, Berchuck A, Pharoah P, Chenevix-Trench G, Gharahkhani P, Neale R, Webb P, MacGregor S. Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study. International Journal Of Epidemiology 2016, 45: 1619-1630. PMID: 27594614, PMCID: PMC5100621, DOI: 10.1093/ije/dyw207.Peer-Reviewed Original ResearchConceptsVitamin D levelsOvarian cancerVitamin DD levelsOdds ratioObservational studySingle nucleotide polymorphismsD concentrationsPlasma vitamin D levelsHigh-grade serous ovarian cancerHigh-grade serous epithelial ovarian cancerMendelian randomizationSerous epithelial ovarian cancerEpithelial ovarian cancer riskEpithelial ovarian cancerOvarian cancer riskOvarian Cancer Association ConsortiumSerous ovarian cancerObservational epidemiological studiesTwo-sample MR approachInverse variance weightingMendelian randomization studyOvarian cancer susceptibilityCancer preventionCancer risk
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