2025
A series of hydroxychloroquine-associated cardiotoxicity presenting with heart failure
Nazarenko N, Maliha M, Parker M, Borkowski P, Csecs I, Tauras J, Shin J, Pullman J, Sims D, Rochlani Y. A series of hydroxychloroquine-associated cardiotoxicity presenting with heart failure. Annals Of Medicine And Surgery 2025, 87: 1334-1340. PMID: 40213182, PMCID: PMC11981468, DOI: 10.1097/ms9.0000000000002997.Peer-Reviewed Original ResearchSystemic lupus erythematosusHCQ useHeart failureCardiac abnormalitiesCardiac magnetic resonance imagingDose-dependent complicationsRheumatoid arthritisCases of SLE patientsDiscontinuation of hydroxychloroquineResolution of symptomsLong-term therapyEarly detectionShortness of breathA-V blockHCQ therapyMagnetic resonance imagingPrompt discontinuationEndomyocardial biopsyPulmonary hypertensionEjection fractionHF therapyCardiac symptomsImprove patient outcomesSLE patientsSjogren's syndrome
2021
Evaluating the risk of QTc prolongation associated with hydroxychloroquine use with antidepressants in lupus patients with fibromyalgia
Renaldi J, Koumpouras F, Dong X. Evaluating the risk of QTc prolongation associated with hydroxychloroquine use with antidepressants in lupus patients with fibromyalgia. Lupus 2021, 30: 1844-1848. PMID: 34353174, DOI: 10.1177/09612033211034562.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusQTc prolongationHCQ useLupus patientsQTc intervalFibromyalgia syndromeDose of hydroxychloroquineLethal ventricular arrhythmiasMild QTc prolongationElectronic medical recordsHydroxychloroquine useLupus erythematosusVentricular arrhythmiasMedical recordsBazett's formulaCardiological conditionsOverall prolongationSudden deathHydroxychloroquineImmunomodulatory propertiesAntidepressantsPatientsDrug useConcurrent useECG monitoring
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