2018
The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway
Addy NA, Nunes EJ, Hughley SM, Small KM, Baracz SJ, Haight JL, Rajadhyaksha AM. The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway. Neuropsychopharmacology 2018, 43: 2361-2372. PMID: 29773910, PMCID: PMC6180103, DOI: 10.1038/s41386-018-0080-2.Peer-Reviewed Original ResearchConceptsL-type calcium channelsCocaine relapseLever depressionVentral tegmental areaCocaine self-administration trainingOriginal training contextLight cue presentationSelf-administration trainingSubjective effectsCocaine-seeking behaviorTegmental areaBehavioral effectsCocaine's subjective effectsL-type calcium channel blockerCue presentationMale Sprague-Dawley ratsTraining contextCocaine cuesNucleus accumbens coreNatural rewardsDA receptor activationCalcium channel blockersSprague-Dawley ratsPhasic dopaminePotential therapeutic target
2007
Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men
Hyman SM, Paliwal P, Chaplin TM, Mazure CM, Rounsaville BJ, Sinha R. Severity of childhood trauma is predictive of cocaine relapse outcomes in women but not men. Drug And Alcohol Dependence 2007, 92: 208-216. PMID: 17900822, PMCID: PMC2233653, DOI: 10.1016/j.drugalcdep.2007.08.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAdult Survivors of Child AbuseChildChild Abuse, SexualCocaine-Related DisordersData Interpretation, StatisticalFemaleFollow-Up StudiesHumansInpatientsMaleMiddle AgedPredictive Value of TestsProspective StudiesPsychiatric Status Rating ScalesRecurrenceSex CharacteristicsSocioeconomic FactorsSubstance Abuse Treatment CentersSurveys and QuestionnairesConceptsOverall childhood traumaCocaine relapse outcomesChildhood traumaEmotional abuseRelapse outcomesChildhood emotional abuseCocaine treatment outcomesCocaine-dependent menCocaine-dependent adultsCocaine relapseAssociation of severityRisk of relapseSexual abusePhysical abuseGender-specific effectsInitial relapseDay cocaineCocaine dependenceDependent adultsInpatient SampleInpatient treatmentTreatment outcomesGreater severityAbuseDependent men
2006
Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha R, Garcia M, Paliwal P, Kreek MJ, Rounsaville BJ. Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes. JAMA Psychiatry 2006, 63: 324-331. PMID: 16520439, DOI: 10.1001/archpsyc.63.3.324.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultBehavior, AddictiveCocaine-Related DisordersCuesFemaleFollow-Up StudiesHospitalizationHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemProspective StudiesSecondary PreventionStress, PsychologicalSubstance Abuse Treatment CentersTreatment OutcomeConceptsAdrenal axis responseCocaine cravingRelapse outcomesAxis responseCocaine relapseAdrenal responseInpatient treatmentCocaine relapse outcomesCue-induced cocaine cravingStress-induced drug cravingCocaine useCocaine dependenceCox proportional hazards regressionCommunity mental health centerProportional hazards regressionMental health centersProspective study designDrug cue exposureStress-related increasesTreatment-seeking cocaine dependent individualsHazards regressionHypothalamic-PituitaryHealth centersCocaine-dependent individualsRelapse
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