2023
Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice
Stevens H, Scuderi S, Collica S, Tomasi S, Horvath T, Vaccarino F. Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice. Translational Psychiatry 2023, 13: 89. PMID: 36906620, PMCID: PMC10008554, DOI: 10.1038/s41398-023-02372-y.Peer-Reviewed Original ResearchConceptsFibroblast growth factor receptor 2Anxiety-like behaviorAttention deficit hyperactivity disorderAstroglial cellsGrowth factor receptor 2Reduced anxiety-like behaviorGlia-neuron interactionsAstroglial cell functionEarly postnatal periodFactor receptor 2Early postnatal lossPostnatal mouse brainWeeks of ageDeficit hyperactivity disorderGlial cellsGlutamine synthetase expressionBehavioral deficitsPostnatal periodReceptor 2Floxed miceHGFAP-CreMouse brainNeonatal lossPostnatal astrogliaPostnatal lossBDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis
Usmani M, Krattli R, El-Khatib S, Le A, Smith S, Baulch J, Ng D, Acharya M, Chan A. BDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis. Neurotherapeutics 2023, 20: 838-852. PMID: 36720792, PMCID: PMC10275819, DOI: 10.1007/s13311-022-01339-z.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorCancer-related cognitive impairmentCognitive impairmentReduced anxiety-like behaviorDentate neurogenesisReduction of BDNF levelsBlood levels of brain-derived neurotrophic factorFear extinction memory consolidationLevels of brain-derived neurotrophic factorExtinction memory consolidationAnxiety-like behaviorBreast cancer patients treated with doxorubicinHippocampal-dependent learningCancer patients treated with doxorubicinPatients treated with doxorubicinADR-treated miceImpact of riluzoleChemotherapy-induced reductionPre-clinical evidenceMemory consolidationBDNF levelsMemory functionCognitive functionCognitive declineIncreased neuroinflammation
2019
Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma
Atif F, Yousuf S, Espinosa-Garcia C, Sergeeva E, Stein D. Progesterone Treatment Attenuates Glycolytic Metabolism and Induces Senescence in Glioblastoma. Scientific Reports 2019, 9: 988. PMID: 30700763, PMCID: PMC6353890, DOI: 10.1038/s41598-018-37399-5.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsApoptosisBehavior, AnimalBiomarkersCell Line, TumorCell ProliferationCell SurvivalCellular SenescenceEnzyme AssaysGlioblastomaGlycolysisLuciferasesMice, NudeModels, BiologicalMotor ActivityNeovascularization, PathologicPhosphatidylinositol 3-KinasesProgesteroneProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesConceptsGrowth of glioblastoma multiformeGlycolytic metabolismEffect of progesterone treatmentHigh-dose progesteroneReduced anxiety-like behaviorFollow-up in vitro studyOrthotopic mouse modelSpontaneous locomotor activityAnxiety-like behaviorAthymic nude miceInduce senescenceExpression of GLUT1Increased survival rateCytoplasmic FOXO1Tumor sizeTumor establishmentProgesterone administrationProgesterone treatmentTumor cellsTumor progressionInduce premature senescenceFollow-upNude micePeripheral organsLocomotor activity
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