2025
Endovascular Stenting for Acute Ischemic Stroke Due to Cervical Artery Dissection: Nationwide Study of Stroke Recurrence
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. Endovascular Stenting for Acute Ischemic Stroke Due to Cervical Artery Dissection: Nationwide Study of Stroke Recurrence. Stroke Vascular And Interventional Neurology 2025, 5 DOI: 10.1161/svin.124.001726.Peer-Reviewed Original ResearchCervical artery dissectionRate of intracranial hemorrhageNo-stent groupStent groupIntracranial hemorrhageEndovascular stentingAcute ischemic strokeArtery dissectionRate of short-term morbidityStroke recurrenceDays of follow-upSecondary end pointsShort-term morbidityRetrospective cohort studyRate of recurrent strokeRate of stroke recurrenceMaintain vessel patencyPropensity score matchingRoutine dischargeRate of routine dischargeAdult patientsRecurrence riskLogistic regression modelsOcclusive lesionsFollow-upSilent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial
Ridha M, Zhang C, McCullough S, Viscoli C, Sharma R, Kamel H, Merkler A. Silent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial. Journal Of The American Heart Association 2025, 14: e037663. PMID: 39921499, PMCID: PMC12074768, DOI: 10.1161/jaha.124.037663.Peer-Reviewed Original ResearchConceptsSilent MISilent myocardial infarctionStroke recurrenceClinical MIAssociated with stroke recurrenceFirst-ever strokeMyocardial infarctionIschemic strokeTailored prevention strategiesRecurrent strokeVascular risk factorsHistory of hospitalizationRisk of stroke recurrenceEvidence of MIUnadjusted analysisPrevention strategiesInclusion criteriaSecondary outcomesECG evidence of MIPrimary outcomeRisk factorsMultivariate Cox regression analysisPost Hoc AnalysisStrokeRegression analysis
2024
Impact of Poverty on Stroke Recurrence: A Population-Based Study.
Becker C, Sucharew H, Robinson D, Stamm B, Royan R, Nobel L, Stanton R, Jasne A, Woo D, De Los Rios La Rosa F, Mackey J, Ferioli S, Mistry E, Demel S, Haverbusch M, Coleman E, Slavin S, Walsh K, Star M, Flaherty M, Martini S, Kissela B, Kleindorfer D. Impact of Poverty on Stroke Recurrence: A Population-Based Study. Neurology 2024, 102: e209423. PMID: 38759136, PMCID: PMC11175648, DOI: 10.1212/wnl.0000000000209423.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic statusPopulation-based studyIncident strokeCensus tractsSecondary analysisGreater Cincinnati/Northern Kentucky regionStroke recurrencePoisson regression modelsPoverty lineFederal poverty lineRecurrent strokeRecurrence riskVascular risk factorsResidents of poor neighborhoodsStudy periodAmerican Community SurveyNeighborhood povertySocioeconomic statusExcess riskStroke incidenceImpact of povertyPrimary exposureRelative riskStroke recurrence riskWhite individuals
2023
Association of short-term hospital-level outcome metrics with 1-year mortality and recurrence for US Medicare beneficiaries with ischemic stroke
Wang Y, Leifheit E, Goldstein L, Lichtman J. Association of short-term hospital-level outcome metrics with 1-year mortality and recurrence for US Medicare beneficiaries with ischemic stroke. PLOS ONE 2023, 18: e0289790. PMID: 37561680, PMCID: PMC10414659, DOI: 10.1371/journal.pone.0289790.Peer-Reviewed Original ResearchConceptsIschemic strokeInverse probability weightsStroke patientsCause mortalityOutcome metricsLower riskUS hospitalsBetter long-term outcomesRecurrent stroke rateIschemic stroke recurrenceIschemic stroke patientsLong-term outcomesUS Medicare beneficiariesPerformance categoriesIntermediate hospitalsRecurrent strokeStroke recurrenceCohort studyClinical factorsRecurrence ratePrincipal diagnosisPatient riskStroke rateReadmission measuresCox modelBorderzone Infarcts and Recurrent Cerebrovascular Events in Symptomatic Intracranial Arterial Stenosis: A Systematic Review and Meta-Analysis
Das S, Shu L, Morgan R, Shah A, Fayad F, Goldstein E, Chahien D, Maglinger B, Bokka S, Owens C, Abbasi M, Kvernland A, Siegler J, Mac Grory B, Nguyen T, Furie K, Khatri P, Mistry E, Prabhakaran S, Liebeskind D, Romano J, de Havenon A, Palaiodimou L, Tsivgoulis G, Yaghi S. Borderzone Infarcts and Recurrent Cerebrovascular Events in Symptomatic Intracranial Arterial Stenosis: A Systematic Review and Meta-Analysis. Journal Of Stroke 2023, 25: 223-232. PMID: 37282372, PMCID: PMC10250880, DOI: 10.5853/jos.2023.00185.Peer-Reviewed Original ResearchBorderzone infarctsIntracranial arterial stenosisRisk ratioNeurological deteriorationSystematic reviewRecurrent strokeInfarct patternsArterial stenosisAnterior circulation stroke patientsSymptomatic intracranial arterial stenosisRecurrent cerebrovascular eventsPosterior circulation strokeSymptomatic ICACerebrovascular eventsStroke recurrenceTerritorial infarctsDistal perfusionRecurrence rateStroke patientsSubgroup analysisThrombus embolizationOutcome eventsPlaque progressionInclusion criteriaHigh risk
2022
Technical Dissonance in Home Blood Pressure Monitoring After Stroke: Having the Machine, but Not Using Correctly.
Forman R, Viscoli C, Meurer K, Sheth K, Sansing L, de Havenon A, Sharma R, Mariscal M, Kernan W. Technical Dissonance in Home Blood Pressure Monitoring After Stroke: Having the Machine, but Not Using Correctly. American Journal Of Hypertension 2022, 36: 195-200. PMID: 36520024, PMCID: PMC10016067, DOI: 10.1093/ajh/hpac129.Peer-Reviewed Original ResearchConceptsHome blood pressure monitoringBlood pressure monitoringBlood pressurePressure monitoringNon-Hispanic white patientsProportion of patientsCross-sectional studyNon-Hispanic white participantsStroke recurrenceRate of useMost patientsPrimary outcomeWhite patientsRate of possessionPatientsUnderrepresented patientsArm cuffHypertensionStrokeCorrect useWhite participantsSignificant disparitiesEthnic groupsParticipantsQuality of techniqueTrends in 1-Year Recurrent Ischemic Stroke in the US Medicare Fee-for-Service Population
Leifheit EC, Wang Y, Goldstein LB, Lichtman JH. Trends in 1-Year Recurrent Ischemic Stroke in the US Medicare Fee-for-Service Population. Stroke 2022, 53: 3338-3347. PMID: 36214126, PMCID: PMC11059192, DOI: 10.1161/strokeaha.122.039438.Peer-Reviewed Original ResearchConceptsRecurrent ischemic strokeIschemic strokeRecurrence rateMedicare beneficiariesRecurrent stroke rateSecondary stroke preventionPoor general healthHigh-risk populationHigh recurrence rateService Medicare beneficiariesUS Medicare feeHighest sextileRecurrent strokeStroke preventionStroke recurrenceClinical characteristicsCohort studyGeneral healthPrincipal diagnosisStroke rateUninsured adultsCox modelMedicare feeHigh recurrenceTesting ratesRacial Disparities in Stroke Recurrence
Robinson DJ, Stanton R, Sucharew H, Alwell K, Haverbusch M, De Los Rios La Rosa F, Ferioli S, Coleman E, Jasne A, Mackey J, Star M, Mistry EA, Demel S, Slavin S, Walsh K, Woo D, Kissela B, Kleindorfer DO. Racial Disparities in Stroke Recurrence. Neurology 2022, 99: e2464-e2473. PMID: 36041865, PMCID: PMC9728039, DOI: 10.1212/wnl.0000000000201225.Peer-Reviewed Original ResearchConceptsTraditional stroke risk factorsStroke risk factorsRisk factorsBlack raceRecurrent strokeStroke recurrenceRecurrence rateHigh riskGreater Cincinnati/Northern Kentucky populationBlack individualsStroke/TIA eventsRacial disparitiesStroke recurrence rateMultivariable survival analysisRisk of recurrenceKaplan-Meier estimatesSignificant racial disparitiesTIA eventsIncident strokeSmoking statusVentricular hypertrophyStroke casesRecurrenceSurvival analysisYounger age
2021
Cilostazol for Secondary Stroke Prevention
de Havenon A, Sheth KN, Madsen TE, Johnston KC, Turan TN, Toyoda K, Elm JJ, Wardlaw JM, Johnston SC, Williams OA, Shoamanesh A, Lansberg MG. Cilostazol for Secondary Stroke Prevention. Stroke 2021, 52: e635-e645. PMID: 34517768, PMCID: PMC8478840, DOI: 10.1161/strokeaha.121.035002.Peer-Reviewed Original ResearchConceptsSecondary stroke preventionStroke preventionDouble-blind placebo-controlled randomized trialLargest secondary stroke prevention trialSecondary stroke prevention trialsPlacebo-controlled randomized trialStroke Prevention TrialTreatment of claudicationOpen-label designNoncardioembolic ischemic strokePeripheral arterial diseaseLong-term treatmentOnset of benefitDays of treatmentEuropean Medicines AgencyCognitive outcome dataMillions of patientsPremature trial terminationDrug discontinuationMajor bleedingGastrointestinal symptomsStroke recurrenceIschemic strokeNoncardioembolic strokeSecondary preventionEvaluation of Systolic Blood Pressure, Use of Aspirin and Clopidogrel, and Stroke Recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial
de Havenon A, Johnston SC, Easton JD, Kim AS, Sheth KN, Lansberg M, Tirschwell D, Mistry E, Yaghi S. Evaluation of Systolic Blood Pressure, Use of Aspirin and Clopidogrel, and Stroke Recurrence in the Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke Trial. JAMA Network Open 2021, 4: e2112551. PMID: 34086033, PMCID: PMC8178708, DOI: 10.1001/jamanetworkopen.2021.12551.Peer-Reviewed Original ResearchConceptsBaseline systolic blood pressureDual antiplatelet therapySystolic blood pressureTransient ischemic attackMinor Ischemic Stroke (POINT) trialNew transient ischemic attackAcute ischemic strokeIschemic strokeIschemic stroke trialsStroke recurrenceHazard ratioBlood pressurePrimary outcomeStroke trialsElevated baseline systolic blood pressureFit Cox proportional hazards modelsHigher baseline systolic blood pressureElevated systolic blood pressureCox proportional hazards modelDays of randomizationFuture stroke riskIschemic stroke recurrenceUse of aspirinSubgroup of patientsProportional hazards model
2020
Poststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis
Yaghi S, Cotsonis G, de Havenon A, Prahbakaran S, Romano JG, Lazar RM, Marshall RS, Feldmann E, Liebeskind DS. Poststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis. Journal Of Stroke And Cerebrovascular Diseases 2020, 29: 104663. PMID: 32044220, PMCID: PMC8985650, DOI: 10.1016/j.jstrokecerebrovasdis.2020.104663.Peer-Reviewed Original ResearchConceptsMontreal Cognitive AssessmentRecurrent ischemic strokeRecurrent strokeIschemic strokeCognitive impairmentMultivariable Cox regression modelsCognitive AssessmentAggressive medical therapyAnterior circulation stenosisIntracranial Stenosis (SAMMPRIS) trialPreventing Recurrent StrokeStroke recurrence riskLong-term morbiditySymptomatic intracranial atherosclerosisCox regression modelPoststroke cognitive impairmentMean followStroke recurrenceIntracranial atherosclerosisMedical therapyPrimary outcomeArtery stenosisIntracranial stenosisStroke patientsMean age
2018
Evidence-Based Performance Measures and Outcomes in Patients With Acute Ischemic Stroke
Wang Y, Li Z, Zhao X, Liu L, Wang C, Wang C, Peterson E, Schwamm L, Fonarow G, Smith S, Bettger J, Wang D, Li H, Xian Y, Wang Y. Evidence-Based Performance Measures and Outcomes in Patients With Acute Ischemic Stroke. Circulation Cardiovascular Quality And Outcomes 2018, 11: e001968. PMID: 30557048, DOI: 10.1161/circoutcomes.115.001968.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrain IschemiaChinaClinical CompetenceDisability EvaluationEvidence-Based MedicineFemaleFibrinolytic AgentsGuideline AdherenceHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePractice Guidelines as TopicPractice Patterns, Physicians'Prospective StudiesQuality ImprovementQuality Indicators, Health CareRecovery of FunctionRegistriesRisk FactorsSmoking CessationStrokeStroke RehabilitationThrombolytic TherapyTime FactorsTime-to-TreatmentTreatment OutcomeConceptsAcute ischemic strokeIschemic strokeOptimal complianceStroke careChina National Stroke RegistryEvidence-based performance measuresMultivariable Cox modelNational Stroke RegistryFavorable functional outcomeProspective cohort studyEvidence-based guidelinesRoutine clinical practiceCause of deathIntravenous tPAStroke recurrenceStroke RegistryCohort studyNationwide registryClinical outcomesFunctional outcomeCare measuresImproved outcomesHospital measuresCox modelClinical practiceUse of Outpatient Rehabilitation Among Adult Stroke Survivors — 20 States and the District of Columbia, 2013, and Four States, 2015
Ayala C, Fang J, Luncheon C, King SC, Chang T, Ritchey M, Loustalot F. Use of Outpatient Rehabilitation Among Adult Stroke Survivors — 20 States and the District of Columbia, 2013, and Four States, 2015. MMWR Morbidity And Mortality Weekly Report 2018, 67: 575-578. PMID: 29795076, PMCID: PMC6433337, DOI: 10.15585/mmwr.mm6720a2.Peer-Reviewed Original ResearchConceptsStroke survivorsBehavioral Risk Factor Surveillance System dataEvidence-based guidelinesDistrict of ColumbiaAdult stroke survivorsSurveillance System dataQuality of lifeSystem-level interventionsPublic health communityStroke recurrenceHospital dischargeOutpatient rehabilitationFunctional outcomeOutpatient settingLeading causeStroke rehabilitationNational guidelinesBRFSS dataHealth systemStrokeHispanic originSurvivorsHealth communityAmerican adultsLevel of education
2010
Quality of Care and Outcomes in Patients With Diabetes Hospitalized With Ischemic Stroke
Reeves M, Vaidya R, Fonarow G, Liang L, Smith E, Matulonis R, Olson D, Schwamm L. Quality of Care and Outcomes in Patients With Diabetes Hospitalized With Ischemic Stroke. Stroke 2010, 41: e409-e417. PMID: 20224058, DOI: 10.1161/strokeaha.109.572693.Peer-Reviewed Original ResearchConceptsQuality of careStroke-related outcomesIschemic stroke patientsStroke patientsRt-PACholesterol treatmentIntravenous recombinant tissue plasminogen activatorRecombinant tissue plasminogen activatorCommon comorbid diseasesGuidelines-Stroke programPercent of patientsSecondary prevention treatmentHours of onsetMultivariable logistic regressionTissue plasminogen activatorUnited States hospitalsQuality improvement effortsGWTG-StrokeHospital mortalityDischarge homeHospital deathHospital outcomesStroke recurrenceComorbid diseasesIschemic stroke
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