2025
Different Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage
Clocchiatti-Tuozzo S, Rivier C, Qureshi A, Renedo D, Huo S, Matouk C, Petersen N, de Havenon A, Sheth K, Rabinstein A, Falcone G, Hawkes M. Different Responses to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage. Neurocritical Care 2025, 1-9. PMID: 40293696, DOI: 10.1007/s12028-025-02269-2.Peer-Reviewed Original ResearchRenal adverse eventsDeep intracerebral hemorrhageIntensive BP reductionRisk of renal adverse eventsRisk of HEHematoma expansionBP reductionATACH-2Intracerebral hemorrhageLobar intracerebral hemorrhageFunctional outcomesAntihypertensive Treatment of Acute Cerebral Hemorrhage IIAcute spontaneous intracerebral hemorrhageAcute intracerebral hemorrhageSpontaneous intracerebral hemorrhageAssociated with reduced riskUnfavorable functional outcomeBlood pressure reductionRandomized clinical trialsMultivariate logistic regression resultsPost Hoc AnalysisAntihypertensive treatmentAdverse eventsClinical trialsIncreased risk
2023
Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage
Avadhani R, Ziai W, Thompson R, Mould W, Lane K, Nanni A, Iacobelli M, Sharrock M, Sansing L, Van Eldik L, Hanley D. Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage. Neurocritical Care 2023, 40: 807-815. PMID: 37919545, PMCID: PMC10959780, DOI: 10.1007/s12028-023-01867-2.Peer-Reviewed Original ResearchIntracerebral hemorrhageNontraumatic intracerebral hemorrhageCerebral edemaFunctional outcomeCause mortalitySymptom onsetAcute central nervous system injuryAcute spontaneous intracerebral hemorrhageEnd pointCentral nervous system injuryDays post randomizationExploratory end pointsPhase 2a studyPlacebo-controlled trialSecondary end pointsAcute brain injuryAcute intracerebral hemorrhageFuture larger trialsPhase 1 studyPerihematomal edema volumeNervous system injurySpontaneous intracerebral hemorrhageInflammatory cytokine concentrationsRate of deathClinical trial protocol
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