Regional Brain Metabolic Correlates of α-Methylparatyrosine–Induced Depressive Symptoms: Implications for the Neural Circuitry of Depression
Bremner JD, Vythilingam M, Ng CK, Vermetten E, Nazeer A, Oren DA, Berman RM, Charney DS. Regional Brain Metabolic Correlates of α-Methylparatyrosine–Induced Depressive Symptoms: Implications for the Neural Circuitry of Depression. JAMA 2003, 289: 3125-3134. PMID: 12813118, PMCID: PMC3233764, DOI: 10.1001/jama.289.23.3125.Peer-Reviewed Original ResearchConceptsNorepinephrine reuptake inhibitorsSelective serotonin reuptake inhibitorsBrain metabolic correlatesDepressive symptomsDorsolateral prefrontal cortexReuptake inhibitorsBrain metabolismMetabolic correlatesPrefrontal cortexPsychiatric research unitDouble-blind trialPositron emission tomography (PET) measurementsDepletion of norepinephrineSerotonin reuptake inhibitorsDifferent neurochemical systemsCommon brain circuitryAMPT administrationInitial medicationPlacebo administrationLimbic areasAcute decreaseDepressed patientsCortical areasPatientsDay 3
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply