2016
Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels
Zhang L, Huang T, Bordey A. Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels. Neuroscience Letters 2016, 629: 15-18. PMID: 27345385, PMCID: PMC4983256, DOI: 10.1016/j.neulet.2016.06.037.Peer-Reviewed Original ResearchConceptsTuberous sclerosis complexDendritic complexityDendritic patterningTotal dendritic lengthTsc1 haploinsufficiencyFLNA levelsNeonatal electroporationDendritic lengthNewborn neuronsDendritic abnormalitiesSholl analysisOlfactory bulbFilamin ATsc1 lossHeterozygote miceCognitive defectsDendritic morphologyMiceA levelsMost individualsHaploinsufficiencyHeterozygote conditionLevelsAbnormalitiesNeurons
2015
The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell
Platel JC, Bordey A. The multifaceted subventricular zone astrocyte: From a metabolic and pro-neurogenic role to acting as a neural stem cell. Neuroscience 2015, 323: 20-28. PMID: 26546469, PMCID: PMC4821790, DOI: 10.1016/j.neuroscience.2015.10.053.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVentricular-subventricular zoneNeural progenitor cellsPro-neurogenic roleHippocampal dentate gyrusNeural stem cellsSubgranular zoneNewborn neuronsNeurogenic propertiesDentate gyrusNew neuronsLateral ventricleAdult brainMature astrocytesTranscription factor expressionNeurogenic fateNeurophysiological characteristicsFactor expressionAstrocytesBlood vesselsProgenitor cellsMetabolic couplingSurvival cuesNeuronsStem cellsCells
2013
Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons
Lafourcade CA, Lin TV, Feliciano DM, Zhang L, Hsieh LS, Bordey A. Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons. Journal Of Neuroscience 2013, 33: 2419-2431. PMID: 23392671, PMCID: PMC3711634, DOI: 10.1523/jneurosci.1840-12.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornCell DifferentiationCell EnlargementCell Line, TumorCell MovementCerebral VentriclesDendritesElectroporationFemaleHypertrophyMaleMiceMonomeric GTP-Binding ProteinsNeural Stem CellsNeurogenesisNeuronsNeuropeptidesOlfactory BulbRas Homolog Enriched in Brain ProteinSirolimusStem CellsTOR Serine-Threonine KinasesConceptsNeural progenitor cellsWild-type miceOlfactory bulbMTOR activitySynaptic inputsEctopic neuronal differentiationSubventricular zone neural progenitor cellsActive ras homologNeuronal differentiationGABAergic synaptic inputsTsc1 mutant miceSubventricular zone progenitorsDendritic complexityNewborn neuronsTuberous sclerosisOlig2 cellsHyperactive mTORHeterozygote miceCircuit formationAction potentialsNeuronal morphologyNewborn cellsMutant miceEctopic cellsMammalian targetHypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex
Feliciano DM, Zhang S, Quon JL, Bordey A. Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex. Human Molecular Genetics 2013, 22: 1725-1734. PMID: 23349360, PMCID: PMC3613161, DOI: 10.1093/hmg/ddt018.Peer-Reviewed Original ResearchConceptsHypoxia-inducible factor 1aTuberous sclerosis complexShort hairpin RNANewborn neuronsFactor 1ASubventricular zoneSVZ stem cellsNewborn neuron survivalNeurogenic subventricular zoneSingle-cell electroporationTranscriptional activityShRNA expressionHairpin RNAMammalian targetMolecular determinantsNovel microenvironmentNeuron deathNeuron survivalOlfactory lesionsNeonatal miceBrain lesionsStem cellsMouse modelNeuron productionSurvival advantage
2012
NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development
Young SZ, Taylor MM, Wu S, Ikeda-Matsuo Y, Kubera C, Bordey A. NKCC1 Knockdown Decreases Neuron Production through GABAA-Regulated Neural Progenitor Proliferation and Delays Dendrite Development. Journal Of Neuroscience 2012, 32: 13630-13638. PMID: 23015452, PMCID: PMC3478384, DOI: 10.1523/jneurosci.2864-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornCalciumCell CountCell DifferentiationCell ProliferationCells, CulturedCerebral VentriclesDendritesEgtazic AcidElectroporationFemaleGABA ModulatorsGABA-A Receptor AgonistsGreen Fluorescent ProteinsIn Vitro TechniquesKi-67 AntigenLuminescent ProteinsMaleMiceMuscimolNeural Stem CellsNeuronsOlfactory BulbPatch-Clamp TechniquesPentobarbitalReceptors, GABA-ARNA, Small InterferingSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2SOXB1 Transcription FactorsTransfectionConceptsNPC proliferationDecreased neuronal densityTotal dendritic lengthNeonatal subventricular zoneNeural stem cell proliferationNeural progenitor cell developmentNeural progenitor proliferationShort hairpin RNADendritic complexityDendritic lengthNeuronal densityNewborn neuronsDendritic arborizationNeuron densityDendritic developmentSubventricular zoneNeuron productionCalcium responseSynaptic integrationNKCC1 knockdownPentobarbital effectsAllosteric agonistDendritic treeProgenitor cell developmentCotransporter NKCC1miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons
Pathania M, Torres-Reveron J, Yan L, Kimura T, Lin TV, Gordon V, Teng ZQ, Zhao X, Fulga TA, Van Vactor D, Bordey A. miR-132 Enhances Dendritic Morphogenesis, Spine Density, Synaptic Integration, and Survival of Newborn Olfactory Bulb Neurons. PLOS ONE 2012, 7: e38174. PMID: 22693596, PMCID: PMC3364964, DOI: 10.1371/journal.pone.0038174.Peer-Reviewed Original ResearchConceptsOlfactory bulb neuronsSynaptic integrationMiR-132Bulb neuronsSpine densityFrequency of GABAergicGlutamatergic synaptic inputsSubventricular zone neurogenesisMiR-132 overexpressionMiR-132 expressionMicroRNA miR-132Neonatal SVZTransplanted neuronsDendritic complexityNewborn neuronsNeuronal survivalPostnatal neurogenesisSynaptic inputsTransplant therapyDendritic morphogenesisNeuronsVivo electroporationSurvivalSignificant increasePlasticity program
2011
Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia
Kang E, Burdick K, Kim J, Duan X, Guo J, Sailor K, Jung D, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra A, Song H, Ming G. Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia. Neuron 2011, 72: 559-571. PMID: 22099459, PMCID: PMC3222865, DOI: 10.1016/j.neuron.2011.09.032.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAnimalsCase-Control StudiesCells, CulturedFemaleGene Knockdown TechniquesGenetic Association StudiesHippocampusHumansMaleMiceMice, Inbred C57BLMiddle AgedNerve Tissue ProteinsNeurogenesisPolymorphism, Single NucleotideProtein BindingRisk FactorsSchizophreniaConceptsDisrupted-in-schizophrenia 1Neuronal developmentElongation protein zeta-1Genetic association analysisRegulate cell positioningRegulation of neuronal developmentDendritic growth of newborn neuronsNewborn neuronsEpistatic interactionsScaffold proteinAssociation analysisSchizophrenia 1Susceptibility genesIntracellular partnersCohort of schizophrenia patientsFEZ1Adult mouse hippocampusRisk of schizophreniaZeta 1Schizophrenia patientsHealthy controlsCell positionIncreased riskMouse hippocampusMental disorders
2009
Eszopiclone and fluoxetine enhance the survival of newborn neurons in the adult rat hippocampus
Su XW, Li XY, Banasr M, Duman RS. Eszopiclone and fluoxetine enhance the survival of newborn neurons in the adult rat hippocampus. The International Journal Of Neuropsychopharmacology 2009, 12: 1421-1428. PMID: 19775501, PMCID: PMC3677220, DOI: 10.1017/s1461145709990629.Peer-Reviewed Original ResearchConceptsNewborn neuronsAntidepressant actionSerotonin uptake inhibitorAdult rat hippocampusAdult hippocampusCombined administrationDorsal hippocampusRat hippocampusPreclinical studiesAdult ratsUptake inhibitorFluoxetineHippocampusNewborn cellsClinical researchEszopicloneBehavioral actionsNeuronsSurvivalAdditive effectNovel mechanismProliferationAntidepressantsPatientsChronicDISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212
Kim J, Duan X, Liu C, Jang M, Guo J, Pow-anpongkul N, Kang E, Song H, Ming G. DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212. Neuron 2009, 63: 761-773. PMID: 19778506, PMCID: PMC3075620, DOI: 10.1016/j.neuron.2009.08.008.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnalysis of VarianceAnimalsAnimals, NewbornCell MovementCells, CulturedFemaleGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGreen Fluorescent ProteinsHippocampusHumansImmunoprecipitationImmunosuppressive AgentsMiceMice, Inbred C57BLNerve Tissue ProteinsNeurogenesisNeuronsOncogene Protein v-aktPregnancyProtein BindingRNA InterferenceSignal TransductionSirolimusTransfectionConceptsDisrupted-in-schizophrenia 1Susceptibility genesMammalian target of rapamycinNeuronal developmentAkt-binding partnersAkt downstream effectorsAkt signalingRegulate multiple aspectsAkt activation in vitroDisrupted-in-schizophreniaMultiple susceptibility genesPharmacological inhibition of mammalian target of rapamycinSchizophrenia susceptibility genesRegulate neuronal developmentSignaling of AktNeurons in vivoAkt-mTOR signaling pathwayInhibition of mammalian target of rapamycinBinding partnersAkt-mTOR signalingDownstream effectorsGenetic manipulationTarget of rapamycinActivity in vitroNewborn neuronsDecision by division: making cortical maps
Rakic P, Ayoub AE, Breunig JJ, Dominguez MH. Decision by division: making cortical maps. Trends In Neurosciences 2009, 32: 291-301. PMID: 19380167, PMCID: PMC3601545, DOI: 10.1016/j.tins.2009.01.007.Peer-Reviewed Original ResearchConceptsNeuronal fate determinationFate determinationFinal mitotic divisionEvolutionary expansionCell determinationMitotic divisionProtomap hypothesisEarly specificationLatest compendiumBiological basisProliferative zoneNeuronal classesNewborn neuronsBroad spectrumDivisionGenesHuman neocortexCortical malformationsNeuronsRadial unitsCompendiumMigrationCerebral wall
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