Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia
Kang E, Burdick K, Kim J, Duan X, Guo J, Sailor K, Jung D, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra A, Song H, Ming G. Interaction between FEZ1 and DISC1 in Regulation of Neuronal Development and Risk for Schizophrenia. Neuron 2011, 72: 559-571. PMID: 22099459, PMCID: PMC3222865, DOI: 10.1016/j.neuron.2011.09.032.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAgedAnimalsCase-Control StudiesCells, CulturedFemaleGene Knockdown TechniquesGenetic Association StudiesHippocampusHumansMaleMiceMice, Inbred C57BLMiddle AgedNerve Tissue ProteinsNeurogenesisPolymorphism, Single NucleotideProtein BindingRisk FactorsSchizophreniaConceptsDisrupted-in-schizophrenia 1Neuronal developmentElongation protein zeta-1Genetic association analysisRegulate cell positioningRegulation of neuronal developmentDendritic growth of newborn neuronsNewborn neuronsEpistatic interactionsScaffold proteinAssociation analysisSchizophrenia 1Susceptibility genesIntracellular partnersCohort of schizophrenia patientsFEZ1Adult mouse hippocampusRisk of schizophreniaZeta 1Schizophrenia patientsHealthy controlsCell positionIncreased riskMouse hippocampusMental disorders
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