Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
Nonomura K, Woo S, Chang R, Gillich A, Qiu Z, Francisco A, Ranade S, Liberles S, Patapoutian A. Piezo2 senses airway stretch and mediates lung inflation-induced apnoea. Nature 2016, 541: 176-181. PMID: 28002412, PMCID: PMC5267560, DOI: 10.1038/nature20793.Peer-Reviewed Original ResearchConceptsSensory neuronsAdult miceSensory neurons of adult miceHering-BreuerPiezo2-mediated mechanotransductionNeurons of adult miceVagal sensory neuronsIncreased tidal volumeResponse to lung inflationSleep apnoeaPerinatal mortalityNewborn miceMechanisms of respiratory controlRespiratory distressRespiratory dysfunctionOptogenetic activationNodose ganglionTidal volumeAirway stretchApnoeaNormal breathingMicePiezo2Lung inflationInducible ablation
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