2013
The role of neurotrophins in major depressive disorder
Jiang C, Salton S. The role of neurotrophins in major depressive disorder. Translational Neuroscience 2013, 4: 46-58. PMID: 23691270, PMCID: PMC3656715, DOI: 10.2478/s13380-013-0103-8.Peer-Reviewed Original ResearchBrain-derived neurotrophic factorDepressive behaviorRole of neurotrophinsMajor depressive disorderTransgenic mouse modelStability of synapsesComplex brain circuitryAntidepressant effectsDendritic lengthSpine densityNeurotrophic factorDepressive disorderNeuronal cytoarchitectureNucleus accumbensMouse modelAnalyses of knockoutBrain circuitryPrefrontal cortexNeurotrophinsGrowth factorSingle nucleotide polymorphismsCritical modulatorHuman genetic studiesSubtle alterationsNucleotide polymorphisms
2009
Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation
Ellenberg D, Shi J, Jain S, Chang JH, Ripps H, Brady S, Melhem ER, Lakkis F, Adamis A, Chen DF, Ellis-Behnke R, Langer RS, Strittmatter SM, Azar DT. Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation. British Journal Of Ophthalmology 2009, 93: 1134. PMID: 19286686, PMCID: PMC2850278, DOI: 10.1136/bjo.2008.155267.Peer-Reviewed Original ResearchConceptsOptic nerve transectionWhole-eye transplantationRGC survivalVisual functionRetinal ganglion cell survivalOuter retina functionGanglion cell survivalOuter retinal functionEye transplantationRetinal functionDonor eyesRetina functionTransectionTransplantationEnucleationSurvivalCell survivalCurrent literatureFuture studiesReviewCold-blooded vertebratesReperfusionNeurotrophinsSpecific questions
2008
Corticosterone Regulates pERK1/2 Map Kinase in a Chronic Depression Model
Gourley SL, Wu FJ, Taylor JR. Corticosterone Regulates pERK1/2 Map Kinase in a Chronic Depression Model. Annals Of The New York Academy Of Sciences 2008, 1148: 509-514. PMID: 19120149, PMCID: PMC3657205, DOI: 10.1196/annals.1410.076.Peer-Reviewed Original ResearchConceptsDepression modelCA1/CA3Chronic depression modelPrefrontal cortical targetsExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Antidepressant efficacyDentate gyrusCorticosterone exposureCortical targetsReceptor typesKinase 1/2Motivated behaviorNovel roleIntracellular signalingPERK1/2MAP kinaseTranscriptional activityNeurotrophinsHippocampusCorticosteroneCA3GyrusMiceInsult
2006
Immunocytochemical evidence for the presence and location of the neurotrophin–Trk receptor family in adult human preovulatory ovarian follicles
Seifer DB, Feng B, Shelden RM. Immunocytochemical evidence for the presence and location of the neurotrophin–Trk receptor family in adult human preovulatory ovarian follicles. American Journal Of Obstetrics And Gynecology 2006, 194: 1129-1134. PMID: 16580310, DOI: 10.1016/j.ajog.2005.12.022.Peer-Reviewed Original ResearchConceptsHuman preovulatory folliclesTrk A receptorCumulus granulosa cellsTrk CTrk BPreovulatory folliclesOvarian folliclesGranulosa cellsFertilization/intracytoplasmic sperm injectionUnfertilized oocytesHuman ovarian folliclesA receptorsAbsence of neurotrophinsIntracytoplasmic sperm injectionPreovulatory ovarian folliclesRespective receptor proteinsReceptor proteinNT-4/5NT-3Prospective studyNeurotrophin receptorSperm injectionNeurotrophinsHuman unfertilized oocytesParacrine function
1997
Spinal Cord Repair: Progress Towards a Daunting Goal
Waxman S, Kocsis J. Spinal Cord Repair: Progress Towards a Daunting Goal. The Neuroscientist 1997, 3: 263-269. DOI: 10.1177/107385849700300414.Peer-Reviewed Original ResearchSpinal cord repairSpinal cordHuman spinal cord injuryUse of neurotrophinsSpinal cord injuryMyelin-forming glial cellsSpinal cord tractsFunctional recoveryNerve graftsAnatomical repairCord injuryGlial cellsAnimal modelsWhite matterGray matterClinical goalsCordInjuryPartial restorationRepairDaunting goalTransplantationNeurotrophinsGraftCNS
1981
Partial purification and characterization of a nerve trophic factor regulating muscle acetylcholinesterase activity
Lentz T, Addis J, Chester J. Partial purification and characterization of a nerve trophic factor regulating muscle acetylcholinesterase activity. Experimental Neurology 1981, 73: 542-557. PMID: 7262254, DOI: 10.1016/0014-4886(81)90288-0.Peer-Reviewed Original ResearchConceptsAcetylcholinesterase activityOrgan cultureRat brain homogenatesMuscle acetylcholinesterase activityTrophic factorsBrain homogenatesUntreated musclesHigh acetylcholinesterase activityTriceps muscleTrophic effectsMuscleUntreated controlsBasic proteinMuscle acetylcholinesteraseIsoelectric focusingActive factorsActive fractionAcetylcholinesteraseMolecular formsNeurotrophinsActivityFactorsSDS-polyacrylamide gel electrophoresis
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