2013
Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators
Patel NC, Schwarz J, Hou XJ, Hoover DJ, Xie L, Fliri AJ, Gallaschun RJ, Lazzaro JT, Bryce DK, Hoffmann WE, Hanks AN, McGinnis D, Marr ES, Gazard JL, Hajós M, Scialis RJ, Hurst RS, Shaffer CL, Pandit J, O’Donnell C. Discovery and Characterization of a Novel Dihydroisoxazole Class of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators. Journal Of Medicinal Chemistry 2013, 56: 9180-9191. PMID: 24215237, DOI: 10.1021/jm401274b.Peer-Reviewed Original ResearchConceptsAMPAR potentiatorsStructure-based drug designAcid receptorsΑ-aminoIsoxazolepropionic acid (AMPA) receptorsPositive allosteric modulatorsIsoxazolepropionic acid receptor potentiatorsRat brain homogenatesActivity screenNeuronal precursorsExcitatory neurotransmissionReceptor potentiatorsBrain homogenatesDrug designNeurological disordersAllosteric modulatorsCognitive deficitsX-ray crystal structureNovel ligandsPotentiatorsPotent compoundsADME propertiesDiscoveryCrystal structure
1981
Partial purification and characterization of a nerve trophic factor regulating muscle acetylcholinesterase activity
Lentz T, Addis J, Chester J. Partial purification and characterization of a nerve trophic factor regulating muscle acetylcholinesterase activity. Experimental Neurology 1981, 73: 542-557. PMID: 7262254, DOI: 10.1016/0014-4886(81)90288-0.Peer-Reviewed Original ResearchConceptsAcetylcholinesterase activityOrgan cultureRat brain homogenatesMuscle acetylcholinesterase activityTrophic factorsBrain homogenatesUntreated musclesHigh acetylcholinesterase activityTriceps muscleTrophic effectsMuscleUntreated controlsBasic proteinMuscle acetylcholinesteraseIsoelectric focusingActive factorsActive fractionAcetylcholinesteraseMolecular formsNeurotrophinsActivityFactorsSDS-polyacrylamide gel electrophoresis
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